Abstract

Introduction: To investigate a long-term in vivo deterioration of polymethylmethacrylate (PMMA) bone cement over time, we evaluated retrieved PMMA cement in terms of chemical elements presenting in the cement using energy dispersive analysis of X-rays; Knoop hardness; and the Young’s modulus using scanning acoustic microscopy. Materials and Methods: For mechanical evaluation, we could neglect the influences of entrapped air bubbles or blood by the use of small specimens. The study was based on thirteen cement samples (six used in the acetabulum and seven in the femur) derived from eight patients (age at revision surgery: mean 72.5, range 68 to 79). All of these samples were Simplex-P^?cement. They were functioning well at least ten years after the previous surgery. Duration until revision surgery was ranged 12 to 25 years (average, 17.4 years). The reason for revision was aseptic mechanical loosening. Twenty samples of Simplex-P^reg; cement were served by manually mixing as a control. Results: The average of the hardness of the cement was 17.0 ± 1.2 (range, 13.4-20.6). In the control, the hardness was 17.8 ± 1.5 (range, 14.0-24.6). There was no significant difference between these values. The mean of Young’s modulus of the cement was 5.61 ± 0.19 GPa (range, 5.09-6.10). In the control, the modulus was 6.04 ± 0.13 GPa (range, 5.68-6.45). Although the modulus was significantly less than that of the control, there was only 7% decrease in average between twelve and twenty-five years in vivo. Conclusions: Our results suggest that long-term implantation and functional loading in vivo may not be the limiting factor in the mechanical integrity of the bone cement.

Keywords

Polymethylmethacrylate Bone Cement; Biodegradation; Total Hip Arthroplasty; Retrieval Study; Knoop Hardness; Young’s Modulus

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Conflicts of Interest

The authors declare no conflicts of interest.

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