TITLE:
The Influence of Morinda citrifolia (Noni) Fruit Juice on Collagen Deposition in the Skin: A Minireview
AUTHORS:
Brett J. West
KEYWORDS:
Morinda citrifolia, Noni, Collagen, Fibroblast, Matrix Metalloproteinases
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.9,
September
5,
2018
ABSTRACT: The fruit of Morinda citrifolia, commonly known as
noni, has an extensive history of use as a food and medicine throughout the
tropics. Among its many uses, noni was believed to promote skin health. In vivo wound healing studies reveal
that noni fruit juice ingestion increases collagen production and deposition
via increased expression of extracellular matrix protein genes. Noni juice also
appears to promote fibroblast proliferation. In vitro studies indicate
that noni juice also protects fibroblasts via activation of the transcription
factor Nrf2 and protects extracellular matrix collagen by inhibiting matrix
metalloproteinases. In vitro and in vivo study findings are corroborated
by a clinical trial where hospitalization times were reduced, and wound
granulation quality was improved in pediatric burn patients. The findings of
other human studies also indicate that noni juice has the potential to protect
skin collagen. These include reduced plasma reactive oxygen species in
cigarette smokers, lowered skin glycation levels in overweight and obese
adults, as well as reduced skin glycation levels among noni juice consumers
within the general population. These in
vitro, in vivo and human studies
reveal that there are multiple mechanisms of action through which noni juice
promotes collagen synthesis and inhibits collagen degradation. The procollagen
properties of noni juice aid wound healing, increase skin elasticity, and
improve the overall appearance of the skin.