TITLE:
Clinical, Pathological and Surgical Risk Factors Associated with Craniopharyngioma Recurrence: A Literature Review
AUTHORS:
James Lubuulwa, Zhuang Miao, Shengwen Liu, Juan Chen, Sheng Wang, Wei Jiang, Kai Shu, Ting Lei
KEYWORDS:
Craniopharyngioma, Recurrence, Risk Factors, Subtotal Resection
JOURNAL NAME:
Open Journal of Modern Neurosurgery,
Vol.9 No.1,
January
23,
2019
ABSTRACT: Objective: This review article attempts to examine and provide an overview of the risk factors associated with craniopharyngioma recurrence. Methods: A literature review of articles relating to the recurrences of craniopharyngioma and the clinical, molecular prognostic indicators of recurrence and treatment outcomes was performed retrospectively. Results: A total of 107 studies which described specific risk factors related to craniopharyngioma recurrence were identified which included but not limited to 54 retrospective case series, 7 systematic reviews, 21 laboratory reports, 13 case reports and 12 literature reviews. Conclusion: Based on the evidence identified in this review, the risk factors for recurrence in craniopharyngioma management are interrelated in a complex way, and surgery with or without adjuvant radiotherapy is reported to be of long-term benefit, but a disparity in findings suggests no definitive consensus on the risk factors of craniopharyngioma recurrence. More high-quality research is needed.