TITLE:
Assessing of the Therapeutic Efficacy of These 2 Treatment Regimens in the Management of Helicobacter pylori Infection at Kinshasa
AUTHORS:
Antoine Tshimpi, Patrick de Jésus Ngoma-Kisoko, Aurore Beia, Tressy Kalenga-Ngomba, Jacqueline Nkondi, Fabrice Bokabanja, Heritier Mawalala, Trésor Monsere, Pitshou Kengibe, Mireille Nganga Nkanga, Benjamin Longo-Mbenza
KEYWORDS:
Helicobacter pylori, Concomitant Quadruple Therapy, Sequential Quadruple Therapy, Eradication, Kinshasa
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.12 No.3,
March
17,
2022
ABSTRACT: Introduction: Helicobacter pylori (Hp) infection is a worldwide public health problem. Unfortunately, its
management poses a problem because of resistance to antibiotics. However, there
are codified treatment protocols covering sequential and concomitant
quadritherapy with regard to first-line probabilistic treatment. The objective
of this study was to assess the therapeutic efficacy of these 2 treatment
regimens in the management of Hp infection at Kinshasa. Methods: This was a mixed study, with documentary,
descriptive and interventional approaches, carried out between September 1,
2018 and April 30, 2020. Results: Sixty-four patients were collected, including 36 men
against 28 women with a sex ratio of 1H:1F; the mean age was 54 ± 16.5 years.
There was an over-representation of senior patients (n = 29); an intermediate
number of adult patients (n = 22) and a lower number of young patients (n = 13).
34 and 30 were respectively treated according to the concomitant and sequential
regimens. Concomitant quadruple therapy offered an eradication rate of 91.2%
compared to 56.7% for sequential quadruple therapy; concomitant treatment,
advancing age and absence of risky behavior more quickly predicted the
occurrence of eradication success. Conclusion: The present study showed superiority of concomitant
quadruple therapy over sequential quadruple therapy in first-line treatment.
Alcohol with active smoking had a negative
influence, while concomitant quadruple therapy, advancement in age had a
positive influence on the success of the eradication of Hp infection.