TITLE:
Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions
AUTHORS:
Saeed Balalaie, Shahrzad Abdolmohammadi, Bita Soleimanifard
KEYWORDS:
Arylmethylidene Pyruvic Acid; Hexahydro-2-quinolinecarboxylic Acids; Solvent-Free Conditions; One-Pot Three-Component Reaction
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.3,
September
28,
2012
ABSTRACT: A simple and fastthree-component synthesis of new and biologically active hexahydro-2-quinolinecarboxylic acid scaf-fold 4 was carried out using cyclocondensation reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 under solvent-free conditions and at room temperature. This protocol has the advantages of facility, easy work-up, high yields, short reaction time and environmentally friendly character.