#BigEndothelin #heartfailure #coronaryarterydisease #biomarkerELISA #fullyvalidatedforclinicalresearch
Big Endothelin-1 (BigET-1) is a vasoconstrictive peptide that plays a key role in the development of #heartfailure. Our BigET-1 ELISA #assay was successfully used in a large cohort study of nearly 8000 prediabetic and diabetic patients with stable Coronary Artery Disease (CAD). Key highlights: 🔹 Plasma BigET-1 level is an independent predictor of #cardiovascular events (CVEs) in patients with stable CAD. 🔹 BigET-1 remains independently associated with worse cardiovascular outcomes in prediabetic and diabetic patients but not in patients with normoglycemia. 🔹 Patients with diabetes and high Big #Endothelin-1 levels were associated with the highest risk of CVEs in patients with stable CAD. Find out more in the comments below 👇 #biomedica #biomedicaimmunoassays #diabetes #prediction #coronaryarterydisease #biomarkers