Cymphony Bio

I am thrilled to announce that my most recent work on “Dynamic Interface Printing” has now been published in Nature! https://lnkd.in/gaRnVJAh Dynamic Interface Printing (DIP) introduces a new light-based printing modality that utilises a constrained air-liquid interface formed at the extent of a print head, to fabricate high-resolution centimetre scale constructs in just a matter of seconds. By rapidly modulating the pressure within this print head, we demonstrate the formation of surface waves across the meniscus, bolstering mass-transport, material homogenisation and enabling three-dimensional particle patterning during fabrication. Here we show the potential of DIP across an array of materials from hard acrylates to soft cell-laden hydrogels, with features on the order of tens of microns. Additionally, as structures are formed in-situ within a liquid environment, this technique addresses previous shortcomings regarding structural stability of highly soft materials and their subsequent manual handling, by enabling fabrication directly into biological consumables. We further show how the use of a permeable air-liquid interface as a fabrication method, also permits the overprinting of multi-material or multi-component structures, in addition to material transfer by print head pipetting. A fantastic writeup by Hayden Taylor on the potential uses of Dynamic Interface Printing for space can also be found here: https://lnkd.in/gkz9W5ZH Hayden's team, including Taylor Waddell at University of California, Berkeley have already stated making this concept a reality with their SpaceCAL system! Hopefully we can follow suit Australian Space Agency? I am confident that this work will propel advancements in 3D printing, material science, and biofabrication, and I am excited about its potential impact and future collaborations stemming from this work. I would like to thank my collaborators for which this work could not have been possible including Michael Halwes, Kirill Kolesnik, Philipp Segeritz, Matthew Mail, Anders Barlow, Emmanuelle Koehl, Anand Ramakrishnan, Lilith Caballero Aguilar, David Nisbet, Daniel Scott, Daniel Heath, Kenneth Crozier, David Collins and the rest of the CBML lab. I would also like to thank my partner Dulashi (Anna) Withanage Dona for her immense support! Along with my family Matt Woods, Indra Dona and friends. I would like to highlight that this work was supported in part by the Materials Characterisation & Fabrication Platform,Australian Research Council, The Royal Melbourne Hospital and the ARC Centre of Excellence for Transformative Meta-Optical Systems (TMOS) #3Dprinting #AdditiveManufacturing #Microfabrication #Biofabrication #Bioprinting #AdvancedManufacturing #Optics

Thanks to Callum Vidler and Michael Halwes from University of Melbourne and Cymphony Bio for giving us a live demo on Dynamic Interface Printing (DIP). If you haven't heard of this additive manufacturing technique, I strongly recommend giving this article a read. 📖 Full paper: https://lnkd.in/gk2fJYwc The technique tackles two major problems - a) print speed and b) cell sedimentation - that have limited the widespread adoption of #3d #bioprinting. Imagine being able to shorten the time it takes to print tissue scaffolds from hours to seconds with the added benefits of a) fabricating structures directly into well plates and b) being able to customise fabrication surface and mitigate cell sedimentation via acoustic modulation. It's a real game changer. I have no doubt that as they embark on their commercialisation journey they will start to attract attention from leading research groups around the world. #3dprinting #organoids #organonachip #regenerativemedicine