McEwen Stem Cell Institute

✨ Celebrating World Diabetes Day with Breakthrough Discoveries in Pancreatic Development 🧪🧫 Today, on World Diabetes Day, we’re excited to share a groundbreaking discovery from the McEwen Stem Cell Institute at University Health Network! Our research team, led by Drs. Adriana Migliorini and Cristina Nostro, has uncovered the remarkable role that immune cells—specifically macrophages—play in supporting the development of insulin-producing cells in the pancreas. Using advanced RNA sequencing, our researchers demonstrated that macrophages significantly enhance the success of transplanting organoids into tissue. These findings could be key to unlocking new treatments for diabetes, particularly Type 1 diabetes, which arises from immune system dysfunction during pancreas formation. As we honour the legacy of Dr. Frederick Banting, co-discoverer of insulin, we’re reminded of the power of research to transform lives. By continuing to explore the vital role of immune cells, we move one step closer to creating innovative diabetes therapies and supporting those affected by this condition. Read more: https://lnkd.in/gC6cwR78 Research at UHN; Banting and Best Diabetes Centre; Breakthrough T1D; Canadian Institutes of Health Research | Instituts de recherche en santé du Canada; Medicine by Design - University of Toronto; Canada Foundation for Innovation/Fondation canadienne pour l'innovation; Ontario Institute for Regenerative Medicine #WorldDiabetesDay #DiabetesResearch #PancreasDevelopment

Exciting progress in Parkinson’s Disease research! 📣 BlueRock Therapeutics reports positive 24-month data from the Phase 1 trial of bemdaneprocel, the most advanced pluripotent stem cell-derived cell therapy in the U.S. for Parkinson’s Disease. Conducted at Memorial Sloan Kettering Cancer Center and University Health Network, the study shows a favourable safety profile and promising improvements in motor symptoms, particularly in the high-dose group. These results offer a glimpse into the exciting future of stem cell treatments and their potential to transform the way we treat chronic diseases. #StemCellTherapy #ParkinsonsResearch Krembil Research Institute; Research at UHN; University Health Network; UHN Foundation

A new study from McEwen Stem Cell Institute dives into the challenges of using stem cell-derived heart cells in cardiac treatments, particularly the risk of triggering arrhythmias (irregular heartbeats). Read more here: https://lnkd.in/g8CMVRCm Michael Laflamme, Fanny Wulkan, Rocco Romagnuolo UHN Foundation; Medicine by Design - University of Toronto; BlueRock Therapeutics

🎉 Exciting news! Congratulations to Dr. Shinichiro Ogawa (McEwen Stem Cell Institute) for receiving Innovation Accelerator Fund support, along with Drs. Sarah Crome (Toronto General Hospital Research Institute) and Pamela Ohashi (Princess Margaret Cancer Centre Research)! Learn more below 👇 Research at UHN; Commercialization at UHN; UHN Foundation

Researchers at the Toronto General Hospital Research Institute and McEwen Stem Cell Institute have discovered a new method to study the role of yolk sac macrophages—precursors to immune cells—in human heart development. By engineering primitive macrophages from stem cells and integrating them into 3D heart tissue models, they found that these cells enhance heart muscle function and promote tissue maturation. This breakthrough offers a deeper understanding of how immune cells influence heart development and provides a more accurate model for studying human heart tissue. Homaira Hamidzada; Milica Radisic; Slava Epelman; Michael Laflamme, Gordon Keller, Research at UHN https://lnkd.in/g6T44BSZ

We hosted our inaugural symposium, 'Charting the Path to Stem Cell-Based Therapies' in April. The event showcased cutting-edge advancements in cell therapy and regenerative medicine. A big thank you to our incredible speakers — Drs. Viviane Tabar, Sonja Schrepfer, M.D., Ph.D., Trevor Reichman, Christina Nostro, Elmar Jaeckel, Mitchell Weiss, Shinichiro Ogawa, Lior Zangi, Adam Feinberg, Michael Laflamme, Jonathan Kimmelman, Stephanie Protze, Karun Singh, Yun Li — and our generous sponsors — Krembil Foundation, CCRM, Vistagen, BlueRock Therapeutics, Medicine by Design - University of Toronto, Stem Cell Network, STEMCELL Technologies and PHC Corporation of North America — for making this event a resounding success! Read more 👉 https://lnkd.in/gJKhK5Dg #stemcells #regenerativemedicine UHN Foundation

Kicking things off at the McEwen Stem Cell Institute symposium with opening remarks by McEwen director Gordon Keller. Medicine by Design is proud to be a sponsor. Looking forward to a great day of #regenmed talks.

LAST CHANCE: Register now for the McEwen Institute Symposium on April 18, 2024. Registration closes on Friday, April 5th. 🗓️ April 18, 2024 🕗 8:00 am – 6:00 pm 📍 Toronto Reference Library, The Bram & Bluma Appel Salon (In-person attendance only) What to Expect: 1. Future Impact: Discover how stem cell therapies can revolutionize healthcare. 2. Inspiring Talks: Learn from top researchers and clinicians as they discuss breakthroughs in neurodegenerative disease, diabetes, heart failure, liver disease, and more. 3. Networking: Connect with fellow professionals and explore collaboration opportunities. This event is open to students, researchers, patient partners, and industry leaders. Thanks to our partners — Krembil Foundation, CCRM, Vistagen, Medicine by Design - University of Toronto, BlueRock Therapeutics, Stem Cell Network, STEMCELL Technologies and PHC Corporation of North America — for helping us bring this event to the Toronto community. Agenda and Link to Register: https://lnkd.in/e6Pb6gmn

Are you curious about stem cell research and its potential to transform medicine? Don’t miss the McEwen Institute Symposium where leading experts will share insights on cutting-edge therapies. 🗓️ April 18, 2024 🕗 8:00 am – 6:00 pm 📍 Toronto Reference Library, The Bram & Bluma Appel Salon (In-person attendance only) What to Expect: 1. Future Impact: Discover how stem cell therapies can revolutionize healthcare. 2. Inspiring Talks: Learn from top researchers and clinicians as they discuss breakthroughs in neurodegenerative disease, diabetes, heart failure, liver disease, and more. 3. Networking: Connect with fellow professionals and explore collaboration opportunities. This event is open to students, researchers, patient partners, and industry leaders. Space is limited, so register now to secure your spot! Thanks to our partners — Krembil Foundation, CCRM, Vistagen, Medicine by Design - University of Toronto, BlueRock Therapeutics, Stem Cell Network and STEMCELL Technologies — for helping us bring this event to the Toronto community. Agenda and Link to Register: https://lnkd.in/e6Pb6gmn Research at UHN

Are you passionate about stem cell research and its potential to transform medicine? Don’t miss the McEwen Institute Symposium where leading experts will share insights on cutting-edge therapies. 🗓️ Date: April 18, 2024 🕗 Time: 8:00 am – 6:00 pm 📍 Venue: Toronto Reference Library, The Bram & Bluma Appel Salon (In-person attendance only) What to Expect: 1. Future Impact: Discover how stem cell therapies can revolutionize healthcare. 2. Inspiring Talks: Learn from top researchers and clinicians as they discuss breakthroughs in diabetes, heart failure, liver disease, and more. 3. Networking: Connect with fellow professionals and explore collaboration opportunities. This event is open to students, researchers, patient partners, and industry leaders. Space is limited, so register now to secure your spot! Agenda and Link to Register: https://lnkd.in/e6Pb6gmn Research at UHN University Health Network