3Brain AG

What an incredible experience at the 4th Next-Gen Organ-on-Chips & Organoids Conference! We were proud to sponsor such an event and connect with so many researchers that put their effort into pushing the boundaries of organoid-based research. Particularly intriguing were the advancements in personalized drug screening using patient-derived iPSCs, which hold great potential for tailored treatments and disease modeling. The discussions on Bioconvergence were equally fascinating, highlighting the importance of enhancing stability and diversity in organoid models to drive more reliable and representative research. A big thank you to everyone who stopped by our booth to meet our scientists Sercan Deniz, Diego Fernandez and Adil Gabarli to learn how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ is revolutionizing organoid research with its 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝟯𝗗 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝗱𝗲 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆. We are looking forward to continuing these discussions and exploring new collaborations!! But if you did not have a chance to connect with us at the event, feel free to reach out, we are always eager to discuss how our solutions can help drive your research forward. https://lnkd.in/d_aJqJQJ #3Brain #HDMEA #Neuroscience #Organoids #Electrophysiology #Innovation #ResearchBreakthroughs #CSEM2025

𝗡𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝗮 𝗗𝗶𝘀𝗵 𝗣𝗹𝗮𝘆𝗶𝗻𝗴 𝗮 𝗚𝗮𝗺𝗲 Amazing to see our high-resolution MEA technology enabling closed-loop neuronal system research! This amazing project showcases cultured rat cortical neurons interfacing with our 𝗕𝗶𝗼𝗖𝗔𝗠 𝗗𝘂𝗽𝗹𝗲𝗫 and 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 38/60 enabling a subset of neurons to control a game paddle in real time based on their activity. Wishing you the best of luck continuing this amazing research Elaheh Lotfi! Check out their video about closed-loop neuronal training here! https://lnkd.in/dC2ZiseR 

Are you also attending the 𝟰𝘁𝗵 𝗡𝗲𝘅𝘁-𝗚𝗲𝗻 𝗢𝗿𝗴𝗮𝗻-𝗼𝗻-𝗖𝗵𝗶𝗽𝘀 & 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 CSEM on 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝟭𝟯𝘁𝗵–𝟭𝟰𝘁𝗵? We’re proud to 𝘀𝗽𝗼𝗻𝘀𝗼𝗿 this 𝗽𝗿𝗲𝘀𝘁𝗶𝗴𝗶𝗼𝘂𝘀 𝗺𝗲𝗲𝘁𝗶𝗻𝗴! 𝗩𝗶𝘀𝗶𝘁 𝗼𝘂𝗿 𝗯𝗼𝗼𝘁𝗵 and connect with our neuroscientists, Sercan Deniz & Diego Fernandez, to explore how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ and its 𝟯𝗗 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝗱𝗲 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 is advancing organoid research. 𝗪𝗵𝗮𝘁 𝗺𝗮𝗸𝗲𝘀 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝘂𝗻𝗶𝗾𝘂𝗲?  ✔ 𝟯𝗗 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝗱𝗲𝘀 act as an anchoring system, securing organoids in place  ✔ 𝗦𝗵𝗮𝗹𝗹𝗼𝘄 𝗽𝗲𝗻𝗲𝘁𝗿𝗮𝘁𝗶𝗼𝗻 for high-quality, label-free electrophysiology  ✔ 𝗠𝗶𝗰𝗿𝗼𝗳𝗹𝘂𝗶𝗱𝗶𝗰 𝗱𝗶𝗳𝗳𝘂𝘀𝗶𝗼𝗻 enhances 𝗻𝘂𝘁𝗿𝗶𝗲𝗻𝘁 𝗳𝗹𝗼𝘄 & 𝗰𝗼𝗺𝗽𝗼𝘂𝗻𝗱 𝗮𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻, supporting organoid health and responsiveness Let’s discuss how we can support your research. Come by our booth or 𝘀𝗰𝗵𝗲𝗱𝘂𝗹𝗲 𝗮 𝗺𝗲𝗲𝘁𝗶𝗻𝗴 𝗵𝗲𝗿𝗲! https://lnkd.in/dFqdM8pY #3Brain #HDMEA #Neuroscience #Organoids #Electrophysiology #Research #CompoundApplication 

Will you be attending the 𝗬𝗼𝘂𝗻𝗴 𝗦𝘄𝗶𝘀𝘀 𝗦𝗼𝗰𝗶𝗲𝘁𝘆 𝗼𝗳 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 (𝗙𝗲𝗯 𝟲𝘁𝗵) or the 𝗦𝘄𝗶𝘀𝘀 𝗦𝗼𝗰𝗶𝗲𝘁𝘆 𝗼𝗳 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 (𝗙𝗲𝗯 𝟳𝘁𝗵)? 𝗦𝘁𝗼𝗽 𝗯𝘆 𝗼𝘂𝗿 𝗯𝗼𝗼𝘁𝗵 and chat with Diego Fernandez, our neuroscientist, to explore how our 𝗛𝗗-𝗠𝗘𝗔 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺𝘀 available in 𝟭-𝘄𝗲𝗹𝗹, 𝟲-𝘄𝗲𝗹𝗹, 𝗮𝗻𝗱 𝟮𝟰-𝘄𝗲𝗹𝗹 𝗳𝗼𝗿𝗺𝗮𝘁—can elevate your experiments. 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ featuring both 𝟮𝗗 𝗮𝗻𝗱 𝟯𝗗 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝗱𝗲 𝗱𝗲𝘀𝗶𝗴𝗻𝘀, optimized to meet your experimental needs. Don't miss this opportunity to engage with our team and explore how our solutions can support your research goals. Schedule a meeting here: https://lnkd.in/dnX66ixn #3Brain, #HDMEA, #neuroscience, #research, #electrophysiology 

A huge thank you to everyone who stopped by to connect with Amber Jolly, PhD and Shaun Teacher at the SLAS (Society for Laboratory Automation and Screening) Meeting. It was great to discuss the potential of 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ in advancing neuronal and cardiac research, and to showcase the automation-compatible 𝗛𝘆𝗽𝗲𝗿𝗖𝗔𝗠 𝗗𝗲𝗹𝘁𝗮 for optimizing workflows. We’re excited about the future collaborations and innovations from the discussions we had. If we didn’t get a chance to meet or you’d like to continue the conversation, feel free to 𝗖𝗼𝗻𝘁𝗮𝗰𝘁 𝗨𝘀! https://lnkd.in/d-SEHbxd #3Brain #HDMEA #Neuroscience #Research #Electrophysiology #Automation

A huge congratulations to 𝗭𝗶𝗿𝗮𝗹𝗱𝗼 et al. on their latest publication in 𝗡𝗮𝘁𝘂𝗿𝗲 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 (Nature Portfolio)! We were excited to read the pre-print back in October and are thrilled to see their amazing work on Zaipan2 featured in such a prestigious journal. Don't miss this incredible research—check out how the team coordinated by Stefano Di Marco & Fabio Benfenati utilized the 𝗕𝗶𝗼𝗖𝗔𝗠 𝗫 to explore how Zaipan2 modulates membrane capacitance in response to light intensity. Enabling both excitatory and inhibitory states, helping restore ON and OFF pathways in degenerated retinas, presenting a promising advancement in vision restoration therapy.  Read the full paper here: https://lnkd.in/dYYb54ww #Neuroscience #Retina #VisionRestoration #HDMEA #VisionResearch #electrophysiology #3Brain #Neurodegeneration

𝗗𝗲𝗲𝗽 𝗯𝗿𝗮𝗶𝗻 𝘀𝘁𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻: 𝗘𝗹𝗲𝗰𝘁𝗿𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗳𝗿𝗼𝗺 𝗯𝗿𝗮𝗶𝗻 𝘀𝗹𝗶𝗰𝗲 𝗿𝗲𝗰𝗼𝗿𝗱𝗶𝗻𝗴𝘀 In their recent publication, 𝗞𝗿𝗮𝗴𝗲𝗹𝘂𝗻𝗱 et al. employed 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ and a 𝗕𝗶𝗼𝗖𝗔𝗠 𝗗𝘂𝗽𝗹𝗲𝗫 to investigate how pallidal deep brain stimulation (DBS) affects cerebellar cortical activity in a dystonic hamster model. This innovative study provides an unprecedented view of the functional and network properties of the cerebellar cortex in dystonia and sheds light on how DBS impacts the electrophysiological properties of the model. Kragelung et al identified a reduction in mean firing rate and spike amplitudes in the cerebellum of the dystonia model, which were increased with DBS. Further to this, using the high resolution properties of 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™, they also revealed key network changes, such as a reduction in connectivity within the disease model which was normalised towards a healthy state with DBS. These findings highlight the critical role of the cerebellum in dystonia and the importance of utilizing electrophysiological tools like 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ within movement disorder research. We are grateful to see 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ playing a role in this groundbreaking research. A huge congratulations to Kragelund and colleagues from the Denise Franz group at the 𝗢𝘀𝗰𝗮𝗿 𝗟𝗮𝗻𝗴𝗲𝗻𝗱𝗼𝗿𝗳𝗳 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗼𝗳 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 for this amazing work, this is a step forward in understanding dystonia and the mechanisms of DBS! We can't wait to see more!  Check out the full paper here: https://lnkd.in/dyrnfwme

Will you be at 𝗦𝗼𝗰𝗶𝗲𝘁𝘆 𝗳𝗼𝗿 𝗟𝗮𝗯 𝗔𝘂𝘁𝗼𝗺𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗦𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 on 𝗝𝗮𝗻𝘂𝗮𝗿𝘆 𝟮𝟱𝘁𝗵 – 𝟮𝟵𝘁𝗵? Amber Jolly, PhD and Shaun Teacher will be attending and are excited to connect with you to discuss how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ can advance your neuronal and cardiac research, and to share how the 𝗛𝘆𝗽𝗲𝗿𝗖𝗔𝗠 𝗗𝗲𝗹𝘁𝗮 is automation compatible, to help you optimize and enhance your workflow. Don’t miss the opportunity to meet our team and explore how our solutions can support your research goals. Feel free to reach out and schedule a meeting to learn more! #3Brain, #HDMEA, #neuroscience, #research, #electrophysiology, #automation

𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝗵𝗲𝗹𝗽𝘀 𝗰𝗵𝗮𝗿𝗮𝗰𝘁𝗲𝗿𝗶𝘇𝗲 𝗰𝗼𝗿𝘁𝗶𝗰𝗼𝘀𝗽𝗶𝗻𝗮𝗹 𝗺𝗼𝘁𝗼𝗿 𝗻𝗲𝘂𝗿𝗼𝗻𝘀! Corticospinal motor neurons (CSMNs) are essential for voluntary motor control and their dysfunction is linked to neurological disorders such as amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS) and hereditary spastic paraplegias (HSP). In a recent paper Quintanilla et al. utilized the 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ with the 𝗕𝗶𝗼𝗖𝗔𝗠 𝗗𝘂𝗽𝗹𝗲𝘅 to investigate the functional and network properties of primary motor cortex cultures, focusing on the function, maturation and network properties of CSMNs over time. By coupling the high spatial resolution and single cell recording capabilities of 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ with immunofluorescence imaging, they were able to identify the activity of CSMNs and to characterize in details their functional properties. Alongside this they reveal key alterations in the network properties of the cultures, such as a shift from “random” connectivity organization at 12 DIV to “scale-free” at 15 & 18 DIV. This research not only enhances our understanding of CSMNs, but also creates a foundation for future studies, enabling comparisons with disease models and advancing potential drug discovery efforts. We are thrilled to see 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ contribute to the understanding of CSMNs and we can’t wait to read more of your upcoming research. Congratulations to Christopher Quintanilla and colleagues for this very insightful publication in 𝘚𝘤𝘪𝘦𝘯𝘵𝘪𝘧𝘪𝘤 𝘙𝘦𝘱𝘰𝘳𝘵𝘴 (Nature Portfolio)! Check out the full paper here: https://lnkd.in/du5SyhA4

As the year comes to a close, we’re happy to reflect on an incredible 2024 journey: • Launching the 𝗛𝘆𝗽𝗲𝗿𝗖𝗔𝗠 𝗗𝗲𝗹𝘁𝗮 (https://ln-k.me/BXWq) • Enabling groundbreaking research through our technology, showcased in multiple 𝗵𝗶𝗴𝗵-𝗶𝗺𝗽𝗮𝗰𝘁 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 (https://ln-k.me/WvgN) • Building amazing 𝗽𝗮𝗿𝘁𝗻𝗲𝗿𝘀𝗵𝗶𝗽𝘀 with academia and industry (https://ln-k.me/eBbv) • Advancing innovation through the 𝗠𝗮𝘀𝘀𝗶𝗺𝗼 𝗚𝗿𝗮𝘁𝘁𝗮𝗿𝗼𝗹𝗮 𝗔𝘄𝗮𝗿𝗱 (https://ln-k.me/PrsD)   As we gear up for another exciting year, we remain committed to driving innovation to empower researchers with our technology. Thank you to everyone who has been part of this journey, we can’t wait to see what 2025 will bring!