MaxWell Biosystems

📢📚 A new publication in bioRxiv & medRxiv advances hybrid intelligence and biocomputing by offering valuable insights into neural information encoding and decoding, with the potential to create fully biological computational systems. Congratulations to Joël Küchler, Katarina Vulić, Haotian Yao, Christian Valmaggia, Stephan J. Ihle, Sean Weaver, and János Vörös from ETH Zürich on this pioneering work exploring how information is transmitted and processed in feedforward in vitro neural networks with controlled topology. Their findings deepen our understanding of biological activation functions and information transmission, with promising applications in hybrid and bio-inspired AI systems.👏🧠 Discover how MaxOne Single-Well HD-MEA System enabled precise observation and manipulation of neural activity in in vitro neuronal networks with defined topology. Read the full publication here 👉https://lnkd.in/d6_7xwMB #MaxOne #Neuroscience #ArtificialIntelligence #NeuralNetworks

These days MaxWell Biosystems is attending the ARUK Research Conference in Birmingham, UK! ✨🇬🇧 This conference is a great opportunity to explore new techniques and innovative approaches to advancing dementia research. Our expert team is eager to dive into insightful discussions on enhancing brain health research with next-generation electrophysiology technology. 🧠🔬 If you are attending, don’t miss the chance to connect with Dr. Anastasiia Tourbier (Oryshchuk) Ph.D. and Dr. Marián Hruška-Plocháň! They will be more than happy to share how our cutting-edge platforms can accelerate your research and drive new discoveries in this field. 🧑🔬 📅 February 25 - 26 📍 Birmingham, UK We can’t wait to see you there! #Alzheimers #Dementia #Neuroscience #DrugDiscover Alzheimer's Research UK

Join us at ISSCR International Symposium 2025 in Athens, Greece on April 3 - 4! 🇬🇷🔬 Our ISSCR activities: 📍 Booth 🪧 2 Poster Presentations | April 3 🧑🔬 Innovation Showcase with invited speaker Dr. Yoshiho Ikeuchi | April 4 Will you be in Athens? Let us know, our team of experts would love to meet you there! 👋 Dr. Marie Engelene Obien, Dr. Laura D'Ignazio, PhD, Dr. Silvia Ronchi, Francesco Modena, Dr. Silvia Oldani, PhD, Dr. Marián Hruška-Plocháň. Visit our website for more details and secure your spot at our Innovation Showcase: https://lnkd.in/du2xuKX9 #ISSCR25 #electrophysiology #stemcells International Society for Stem Cell Research

We had a great time last week at the CSEM Next-Gen Organ-on-Chips & Organoids Workshop in Pratteln, Switzerland!✨🇨🇭 Our team had the opportunity to showcase our next-generation HD-MEA technology at the MxW booth, and we would like to thank everyone who stopped by for engaging discussions! It was a pleasure connecting with the inspiring community and learning about the impactful insights shared by exceptional speakers and experts in this field. 🧑🔬 🙏 A special thank you to the organizers for hosting such a fantastic event! (Some images provided by CSEM) #organoids #electrophysiology #innovation

📘 🔬 A new publication in bioRxiv & medRxiv describes an in vitro platform for measuring individual nociceptor electrophysiological responses on HD-MEA, offering a powerful tool for screening potential nociceptor-specific drug candidates. Congratulations to Blandine Clément, Lorenzo Petrella, Lea Wallimann, Jens Duru, Christina Tringides, Janos Vörös, and Dr. Tobias Ruff from ETH Zürich on this groundbreaking work. By integrating HD-MEA with a PDMS-guiding microstructure, the team successfully established a functional phenotypic classification of iPSC-derived nociceptors, uncovering a great diversity of electrophysiological response profiles within this cell population. Notably, only a subset of responses was affected by TRPV1 agonism. This innovative approach holds great promise for advancing subtype-specific drug discovery in neuropathic pain research. 👏 ✨ Discover how MaxOne Single-Well HD-MEA System enabled the detailed profiling of iPSC-derived nociceptors - 🗞️ read the full publication here: https://lnkd.in/dDq6An3F #MaxOne #PainResearch #iPSC #DrugDiscovery

📣 We are excited to attend the CSEM Next-Gen Organ-on-Chips & Organoids Workshop over the next two days! Our team of experts will be there to welcome you in our booth and showcase our next generation electrophysiology platforms. Make sure to stop by to learn more and ask any questions you may have about our products and their applications. 🧑🔬 Meet the team: - Fabian Graf, Account Manager - Dr. Anastasiia Tourbier (Oryshchuk) Ph.D., Field Application Scientist - Simon Sennhauser, Associate Application Scientist We look forward to seeing you! 👋 #Organoids #Electrophysiology

📚🫀 A study published recently in bioRxiv & medRxiv introduces the first hiPSC-derived heart organoid that successfully replicates the coronary vascular plexus and sympathetic neuronal network of the ventricle myocardium, achieving an in vivo-like structural organization and function. Congratulations to Mariana de Araújo Branco, Mafalda Nunes, Ana Luísa Rayagra, Miguel Forte Tenreiro, Joaquim Cabral, and Maria Margarida Diogo from CoLAB AccelBio and iBB-Institute for Bioengineering and Biosciences on this groundbreaking work. This model holds great potential for studying regenerative medicine-based approaches and cardiotoxicity screening, providing a powerful new tool for biomedical research. 👏✨ Discover how the MaxTwo Multiwell HD-MEA System enabled functional characterization of the sympathetic neurons in this heart model. 🗞️ Access the publication here: https://lnkd.in/dxJJ2T2P #MaxTwo #SympatheticNeuron #Electrophysiology

📖🧠 A newly published study in bioRxiv & medRxiv presents the first instance of goal-directed learning in brain organoids through intentionally selected circuits, paving the way for innovative therapeutic applications and advancements in biological computation. Congratulations to Ash Robbins, Hunter Schweiger, Sebastian Hernandez, Alex Spaeth, Kateryna Voitiuk, David F. Parks, Tjitse van der Molen, Jinghui (Sury) Geng, Tal Sharf, Mohammed Mostajo-Radji, David Haussler, and Mircea Teodorescu from University of California, Santa Cruz and UC Santa Barbara for this pioneering work. The team developed a closed-loop electrophysiology framework that integrates mouse cortical organoids into a simulated dynamical task and evaluated learning through high-frequency training signals. Their findings reveal that adaptive training significantly outperforms random training or no training at all. 👏 Learn more about how MaxOne Single-Well HD-MEA enabled precise recording, stimulation, and training of cortical organoids. Access the research here 👉 https://lnkd.in/d8J6vJAR #MaxOne #ArtificialIntelligence #Organoids #Electrophysiology #Biocomputing

We’re delighted to announce a new partnership between Oxford StemTech, King's College London, and MaxWell Biosystems, funded by Innosuisse. Many patients with epilepsy struggle with limited treatment options to manage their seizures effectively. To address this, our collaboration is focused on creating a high-throughput drug testing platform using physiologically relevant models. King’s will provide access to epilepsy patients. By integrating Oxford StemTech’s ReproPlex iPSC reprogramming technology with MaxWell Biosystems’ advanced MaxTwo HD-MEA (High-Density Microelectrode Array) System featuring a 24-well plate format, we can simultaneously analyze multiple patient-specific brain assembloids. This approach will provide a unique platform to understand epilepsy better and test potential new treatments with precision. We are excited to work together on this project and look forward to contributing to advancements in epilepsy research. Please refer to our website for more details 👉 https://lnkd.in/dAqGA2yC Stay tuned for updates! #PrecisionMedicine #Organoids #MEA #Epilepsy #Neuroscience

📚✨ A recent bioRxiv & medRxiv publication advances our understanding of how seizure-like activity is initiated in the human hippocampus. 👏 Congratulations to Matthew Elliott, John Andrews, Tjitse van der Molen, Jinghui (Sury) Geng, Alex Spaeth, Anna Toledo, Kateryna Voitiuk, Cordero Core, Thomas Gillespie, Ari Sinervo, David F. Parks, Ash Robbins, Daniel Solís, Edward Chang, Tomasz Jan Nowakowski, Mircea Teodorescu, David Haussler, and Tal Sharf from University of California, San Francisco, University of California, Santa Cruz, UC Santa Barbara, and University of Washington, on this retrospective analysis of the pioneering experiments using HD-MEA technology on human brain slices. Their findings suggests that structural interconnectivity within the dentate gyrus is a locus for generating seizure-like activity. 🧠 Learn more about how MaxOne Single-Well HD-MEA was used to record activity from hippocampal slices of patients with mesial temporal lobe epilepsy. 🗞️ 👉 Read the full publication here: https://lnkd.in/dDuanRGt #MaxOne #Epilepsy #Hippocampus #HumanBrainSlices