NanoSphere

🟣𝗢𝘂𝗿 𝗹𝗮𝘁𝗲𝘀𝘁 𝗡𝗮𝗻𝗼𝗦𝗽𝗵𝗲𝗿𝗲 𝗡𝗲𝘄𝘀𝗹𝗲𝘁𝘁𝗲𝗿 – 𝗜𝘀𝘀𝘂𝗲 𝟬𝟱 𝗶𝘀 𝗵𝗲𝗿𝗲!  🔗 Get your free copy by subscribing here: https://lnkd.in/eCyE3Pt2 𝗪𝗵𝗮𝘁’𝘀 𝗜𝗻𝘀𝗶𝗱𝗲? Every month, we bring you the latest breakthroughs in nanomedicine—from academia, industry, clinical applications, regulatory updates, and business insights—curated by our expert team: Marija Petrovic-D, PhD, Allegra Peletta, PhD, Mireya L. Borrajo, Olivera Petrovic, Ana Petkovic, and Adèle Rakotonirina, PhD. 📌 𝗗𝗼𝗻’𝘁 𝗺𝗶𝘀𝘀 𝘁𝗵𝗶𝘀 𝗲𝗱𝗶𝘁𝗶𝗼𝗻! 🔥 The hottest topics in nanomedicine 🔍 Exclusive expert insights 💡 Cutting-edge innovations 💬 Want to quickly dive into nanomedicine? 𝗧𝗿𝘆 𝗼𝘂𝗿 𝗽𝗲𝗿𝘀𝗼𝗻𝗮𝗹𝗶𝘇𝗲𝗱 𝗱𝗮𝘁𝗮𝗯𝗮𝘀𝗲, 𝗽𝗼𝘄𝗲𝗿𝗲𝗱 𝗯𝘆 𝗮 𝗖𝗵𝗮𝘁𝗚𝗣𝗧-𝗯𝗮𝗰𝗸𝗲𝗱 𝗽𝗿𝗼𝗺𝗽𝘁 𝗳𝗼𝗿 𝘀𝗺𝗮𝗿𝘁 𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝘀! ➡ https://lnkd.in/eNr_VmYG 🙏 Special thanks to our sponsors: Inside Therapeutics (InsideTx), Nawah Scientific, LitView, and Imdea for making this possible! ⚡ Stay ahead—subscribe now and never miss an update! #Nanosphere #NanomedicineNews #Biotech #MedTech #HealthcareInnovation

🟣 #ComputationalBiology, #AIinHealthcare, #CancerVaccine | 𝗖𝗮𝗻 𝗔𝗜 𝗿𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗶𝘇𝗲 𝗺𝗥𝗡𝗔 𝘃𝗮𝗰𝗰𝗶𝗻𝗲 𝗱𝗲𝘀𝗶𝗴𝗻 𝗳𝗼𝗿 𝗰𝗮𝗻𝗰𝗲𝗿 𝗶𝗺𝗺𝘂𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝘆? 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴 𝘪𝘯 𝘣𝘪𝘰𝘪𝘯𝘧𝘰𝘳𝘮𝘢𝘵𝘪𝘤𝘴 𝘢𝘯𝘥 𝘈𝘐 𝘢𝘳𝘦 𝘵𝘳𝘢𝘯𝘴𝘧𝘰𝘳𝘮𝘪𝘯𝘨 𝘮𝘙𝘕𝘈 𝘷𝘢𝘤𝘤𝘪𝘯𝘦 𝘥𝘦𝘷𝘦𝘭𝘰𝘱𝘮𝘦𝘯𝘵, 𝘰𝘱𝘵𝘪𝘮𝘪𝘻𝘪𝘯𝘨 𝘥𝘦𝘴𝘪𝘨𝘯, 𝘥𝘦𝘭𝘪𝘷𝘦𝘳𝘺, 𝘢𝘯𝘥 𝘦𝘧𝘧𝘪𝘤𝘢𝘤𝘺. 📘 𝗔𝗶𝗺: 🧬 This review explores how AI and computational biology enhance mRNA vaccine design, from neoantigen prediction to lipid nanoparticle (LNP) formulation, enabling more effective cancer immunotherapy. 📊 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 🤖 AI-driven tools improve the prediction of neoantigen structures, guiding mRNA sequence design for targeted immune responses. 💊 AI optimizes mRNA-LNP formulations, enhancing stability and delivery efficiency. 🔬 These innovations improve pharmacokinetics and pharmacodynamics, paving the way for personalized cancer vaccines. 📌 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲: 🚀 AI and computational biology are accelerating the future of mRNA-based cancer immunotherapy, offering precision and scalability in vaccine development. Published in Frontiers in Cellular and Infection Microbiology, January 2025. Read more: https://lnkd.in/gTCV7sQz Thank you to the authors: Saber Imani Xiaoyan Liu Keyi Chen Mazaher Maghsoudloo Parham Jabbarzadeh Kaboli, Ph.D. Mehrdad Hashemi saloomeh khoushab @Xiaoping Li 🔎 Interested in AI-driven cancer immunotherapy? Follow us for the latest breakthroughs! #mRNAVaccines #AIinMedicine #PersonalizedTherapy #CancerResearch

🟣 #LNP #mRNA #DrugDelivery | 𝗛𝗼𝘄 𝗱𝗼 𝗺𝗶𝘅𝗶𝗻𝗴 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀 𝗶𝗺𝗽𝗮𝗰𝘁 𝗟𝗡𝗣-𝗺𝗥𝗡𝗔 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝘀𝗰𝗮𝗹𝗮𝗯𝗶𝗹𝗶𝘁𝘆? 𝘓𝘪𝘱𝘪𝘥 𝘯𝘢𝘯𝘰𝘱𝘢𝘳𝘵𝘪𝘤𝘭𝘦𝘴 (𝘓𝘕𝘗𝘴) 𝘩𝘢𝘷𝘦 𝘳𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘪𝘻𝘦𝘥 𝘨𝘦𝘯𝘦𝘵𝘪𝘤 𝘮𝘢𝘵𝘦𝘳𝘪𝘢𝘭 𝘥𝘦𝘭𝘪𝘷𝘦𝘳𝘺, 𝘣𝘶𝘵 𝘩𝘰𝘸 𝘥𝘰 𝘧𝘰𝘳𝘮𝘶𝘭𝘢𝘵𝘪𝘰𝘯 𝘢𝘯𝘥 𝘱𝘳𝘰𝘤𝘦𝘴𝘴 𝘱𝘢𝘳𝘢𝘮𝘦𝘵𝘦𝘳𝘴 𝘪𝘯𝘧𝘭𝘶𝘦𝘯𝘤𝘦 𝘵𝘩𝘦𝘪𝘳 𝘤𝘩𝘢𝘳𝘢𝘤𝘵𝘦𝘳𝘪𝘴𝘵𝘪𝘤𝘴? 📘 𝗔𝗶𝗺: 🧪 This review explores LNP-mRNA production, focusing on mixing technologies, scalability challenges, and the impact of formulation & process parameters on LNP characteristics. 📊 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 🔬 LNPs are formed by self-assembly during rapid mixing of an aqueous mRNA phase and an organic lipid phase. ⚙️ Continuous methods, particularly T-shaped mixers, are the preferred technology for LNP-mRNA production. 📏 Scaling up from microfluidic chips to millimetric tubing presents challenges in maintaining mixing quality and nanoparticle consistency. 📌 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲: 🚀 Optimizing mixing parameters is crucial for maintaining LNP-mRNA quality at scale, ensuring effective drug delivery. Published in International Journal of Pharmaceutics, March 2025 Check here for more: https://lnkd.in/e9h9sXiT Thank you to the authors: Laurine HOURDEL Noureddine Lebaz Florent PERAL Manon Ripoll @Stéphan Briançon Fethi BENSAID Sumit Luthra Claudia COGNE 🔗 Interested in LNP-mRNA delivery? Follow us for the latest insights! #Nanomedicine #Biopharma #mRNATechnology

🟣 𝗧𝗶𝗿𝗲𝗱 𝗼𝗳 𝗺𝗶𝗻𝗱𝗹𝗲𝘀𝘀 𝘀𝗰𝗿𝗼𝗹𝗹𝗶𝗻𝗴? 𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺 𝘆𝗼𝘂𝗿 𝗳𝗲𝗲𝗱 𝗶𝗻𝘁𝗼 𝗮 𝗸𝗻𝗼𝘄𝗹𝗲𝗱𝗴𝗲 𝗵𝘂𝗯! 𝘐𝘯𝘴𝘵𝘦𝘢𝘥 𝘰𝘧 𝘦𝘯𝘥𝘭𝘦𝘴𝘴 𝘴𝘸𝘪𝘱𝘪𝘯𝘨, 𝘸𝘩𝘺 𝘯𝘰𝘵 𝘭𝘦𝘢𝘳𝘯 𝘱𝘢𝘴𝘴𝘪𝘷𝘦𝘭𝘺 𝘸𝘪𝘵𝘩 𝘕𝘢𝘯𝘰𝘴𝘱𝘩𝘦𝘳𝘦? Here’s how: ✅ 𝗙𝗼𝗹𝗹𝗼𝘄 𝗼𝘂𝗿 𝗮𝗰𝗮𝗱𝗲𝗺𝗶𝗰 𝗟𝗶𝗻𝗸𝗲𝗱𝗜𝗻 𝗽𝗼𝘀𝘁𝘀 𝗳𝗼𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀: https://lnkd.in/ecNd8VDP ✅ 𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝘁𝗼 𝗼𝘂𝗿 𝗻𝗲𝘄𝘀𝗹𝗲𝘁𝘁𝗲𝗿 𝗳𝗼𝗿 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀: https://lnkd.in/eCyE3Pt2 ✅ 𝗥𝗲𝗮𝗱 𝗼𝘂𝗿 𝗶𝗻-𝗱𝗲𝗽𝘁𝗵 𝗯𝗹𝗼𝗴𝘀 𝗼𝗻 𝗻𝗮𝗻𝗼𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲 & 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻: https://lnkd.in/ekJ5cHDi ✅ 𝗥𝗲𝗮𝗱 𝗲𝘅𝗰𝗹𝘂𝘀𝗶𝘃𝗲 𝗶𝗻𝘁𝗲𝗿𝘃𝗶𝗲𝘄𝘀 𝘄𝗶𝘁𝗵 𝗲𝘅𝗽𝗲𝗿𝘁𝘀 (𝗺𝗮𝗻𝘆 𝗰𝗼𝗺𝗶𝗻𝗴 𝘀𝗼𝗼𝗻!):  https://lnkd.in/e-vkKBe8 ✅ 𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗴𝗿𝗼𝘂𝗻𝗱𝗯𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝘀 𝗳𝗿𝗼𝗺 𝗼𝘂𝗿 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝘀: https://lnkd.in/eDbM9PWF ✅ 𝗨𝘀𝗲 𝗼𝘂𝗿 𝗰𝘂𝘀𝘁𝗼𝗺 𝗖𝗵𝗮𝘁𝗚𝗣𝗧 𝗽𝗿𝗼𝗺𝗽𝘁 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀:  https://lnkd.in/eNr_VmYG 🔬 Turn scrolling into learning. Join the movement today! #Nanomedicine #Innovation #LifelongLearning #Nanosphere

🟣 #Nanomedicine, #BrainDrugDelivery, #Glioblastoma | 𝗖𝗮𝗻 𝘁𝗵𝗲 𝗻𝗼𝘀𝗲 𝗯𝗲 𝘁𝗵𝗲 𝗴𝗮𝘁𝗲𝘄𝗮𝘆 𝘁𝗼 𝘁𝗿𝗲𝗮𝘁𝗶𝗻𝗴 𝗯𝗿𝗮𝗶𝗻 𝘁𝘂𝗺𝗼𝗿𝘀? 𝘐𝘯𝘵𝘳𝘢𝘯𝘢𝘴𝘢𝘭 𝘯𝘢𝘯𝘰𝘴𝘺𝘴𝘵𝘦𝘮𝘴 𝘢𝘳𝘦 𝘦𝘮𝘦𝘳𝘨𝘪𝘯𝘨 𝘢𝘴 𝘢 𝘨𝘢𝘮𝘦-𝘤𝘩𝘢𝘯𝘨𝘪𝘯𝘨 𝘴𝘵𝘳𝘢𝘵𝘦𝘨𝘺 𝘧𝘰𝘳 𝘨𝘭𝘪𝘰𝘣𝘭𝘢𝘴𝘵𝘰𝘮𝘢 𝘵𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵. 📘 𝗔𝗶𝗺: 🧠 Exploring nanotechnology-based drug delivery via the olfactory/trigeminal pathway to overcome the blood–brain barrier (BBB) and enhance glioblastoma treatment. 📊 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 🔬 Various nanocarriers—polymeric nanoparticles, lipid-based nanosystems, in situ gels, peptides, and stem cell-based formulations—show promise for targeted brain drug delivery with minimal systemic toxicity. 🧬 Emerging trends in gene therapy and immunotherapy further enhance glioblastoma treatment. ⚠️ Safety, toxicology, and regulatory aspects of intranasal delivery are critical for clinical translation. 📌 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲: 🚀 Nose-to-brain nanodelivery offers a promising, non-invasive route to bypass the BBB and improve glioblastoma management. Published in American Chemical Society, January 2025. Read more here: https://lnkd.in/eKGETySS Thank you to the authors: Tejas Girish Agnihotri Akanksha Dahifale Shyam Kumar Sudhakar Gomte @Biswajit Rout Vasu Peddinti Aakanchha Jain 🔔 Follow us to stay updated on the latest in nanomedicine! #DrugDelivery #CancerResearch #Neuroscience #IntranasalTherapy

🟣 #WomenInScience #GirlsInSTEM #EquityInScience | 𝗪𝗵𝗮𝘁 𝗶𝗳 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝗯𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝗻𝗮𝗻𝗼𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲 𝗰𝗼𝗺𝗲𝘀 𝗳𝗿𝗼𝗺 𝗮 𝘆𝗼𝘂𝗻𝗴 𝗴𝗶𝗿𝗹 𝗶𝗻𝘀𝗽𝗶𝗿𝗲𝗱 𝘁𝗼𝗱𝗮𝘆? 💡 Today, on the International Day of Women and Girls in Science, we celebrate the incredible contributions of women in STEM. 📘 𝗪𝗵𝘆 𝗶𝘁 𝗠𝗮𝘁𝘁𝗲𝗿𝘀: 👩🔬 Women make up less than 30% of researchers worldwide—yet their discoveries are reshaping medicine, technology, and beyond. More representation means more innovation! 📊 𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗕𝗮𝗿𝗿𝗶𝗲𝗿𝘀: 🔬 In nanomedicine and biotechnology, women are leading game-changing research in drug delivery, cancer treatment, and regenerative medicine. 📌 𝗖𝗮𝗹𝗹 𝘁𝗼 𝗔𝗰𝘁𝗶𝗼𝗻: 🌍 Mentor. Inspire. Advocate. Support young girls in STEM, amplify women’s voices, and break down barriers in science. Let’s create a future where talent—not gender—defines success! Tag a woman in science who inspires you! 👏 #WomenInSTEM #STEMEquality #Nanomedicine #FutureInnovators #Nanosphere

🟣 #mRNA #AI #Biotech | 𝗖𝗮𝗻 𝗔𝗜 𝗿𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗶𝘇𝗲 𝗺𝗥𝗡𝗔 𝗱𝗲𝘀𝗶𝗴𝗻 𝗳𝗼𝗿 𝘃𝗮𝗰𝗰𝗶𝗻𝗲𝘀 𝗮𝗻𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀? 𝘐𝘯𝘵𝘳𝘰𝘥𝘶𝘤𝘪𝘯𝘨 𝘮𝘙𝘕𝘈-𝘓𝘔: 𝘢 𝘧𝘶𝘭𝘭-𝘭𝘦𝘯𝘨𝘵𝘩 𝘪𝘯𝘵𝘦𝘨𝘳𝘢𝘵𝘦𝘥 𝘴𝘮𝘢𝘭𝘭 𝘭𝘢𝘯𝘨𝘶𝘢𝘨𝘦 𝘮𝘰𝘥𝘦𝘭 (𝘚𝘓𝘔) 𝘧𝘰𝘳 𝘰𝘱𝘵𝘪𝘮𝘪𝘻𝘪𝘯𝘨 𝘮𝘙𝘕𝘈 𝘴𝘦𝘲𝘶𝘦𝘯𝘤𝘦𝘴. 📘 𝗔𝗶𝗺: 🧬 To enhance mRNA sequence selection by developing an AI-driven model that predicts key properties affecting translation efficiency, stability, and degradation. 📊 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 🖥️ mRNA-LM integrates multiple language models to analyze entire mRNA sequences. 🧪 Trained on millions of mRNA sequences across species, the model captures biological insights on evolution and host–pathogen interactions. 📈 Fine-tuning allows for accurate predictions of mRNA properties, outperforming previous approaches. 📌 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲: 🚀 AI-driven models like mRNA-LM can accelerate the design of optimized mRNA therapeutics, enhancing vaccine development and beyond. Published in Nucleic Acids Research, February 2025. Check here for more: https://lnkd.in/dEQvJD2m Thank you to the authors: Sizhen Li, Shahriar Noroozi Zadeh, Saeed Moayedpour, PhD, Lorenzo Kogler Anele, @Zexin Xue, Dinghai Zheng, Fernando Ulloa Montoya, Vikram Agarwal, Ziv Bar-Joseph, Sven Jager. 🔬 How do you see AI shaping the future of mRNA-based medicine? Let’s discuss! #AIinBiology #mRNATechnology #VaccineDevelopment #MachineLearning

🟣 #mRNA #LipidNanoparticles #DrugDelivery | 𝗖𝗮𝗻 𝘁𝘄𝗲𝗮𝗸𝗶𝗻𝗴 𝗣𝗘𝗚𝘆𝗹𝗮𝘁𝗶𝗼𝗻 𝘂𝗻𝗹𝗼𝗰𝗸 𝗯𝗲𝘁𝘁𝗲𝗿 𝗺𝗥𝗡𝗔 𝗱𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝘁𝗼 𝘁𝗵𝗲 𝗹𝗶𝘃𝗲𝗿? 𝘛𝘩𝘦 𝘢𝘳𝘤𝘩𝘪𝘵𝘦𝘤𝘵𝘶𝘳𝘦 𝘰𝘧 𝘗𝘌𝘎𝘺𝘭𝘢𝘵𝘦𝘥 𝘭𝘪𝘱𝘪𝘥𝘴 𝘱𝘭𝘢𝘺𝘴 𝘢 𝘤𝘳𝘶𝘤𝘪𝘢𝘭 𝘳𝘰𝘭𝘦 𝘪𝘯 𝘭𝘪𝘷𝘦𝘳-𝘵𝘢𝘳𝘨𝘦𝘵𝘦𝘥 𝘮𝘙𝘕𝘈 𝘥𝘦𝘭𝘪𝘷𝘦𝘳𝘺. 📘 𝗔𝗶𝗺: 🧬 To investigate how PEGylated lipids influence lipid nanoparticle (LNP)-mediated mRNA delivery to the liver, focusing on blood circulation, liver deposition, and cell-specific targeting. 📊 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 🔬 The de-PEGylation rate of lipids directly impacts LNP biodistribution—faster de-PEGylation leads to shorter circulation and higher liver accumulation. 🧪 Ultrafast de-PEGylation shifts LNP uptake from hepatocytes to Kupffer cells. 💡 Simply modifying PEG terminal groups (methoxyl → carboxyl/amine) significantly enhances liver-targeted delivery. 📌 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲: 🛠️ Fine-tuning steric lipids offers a powerful tool for optimizing mRNA-LNP formulations, paving the way for more efficient liver-directed therapies. Published in Journal of the American Chemical Society, 2025. Read more: https://lnkd.in/eZKKMv9M Thank you to the authors: @Menghua Gao @Jiafeng Zhong Star LIU Yanjun Zhao @Ding cheng Zhu @Xiaohuo Shi Xuehan Xu Qin Z. WENJING XUAN Yue (Shelby) Zhang @Yaofeng Zhou Jianjun Cheng 🔔 Follow us to get the latest updates in nanomedicine! #LNPs #Biotechnology #RNAtherapy #LiverTargeting #Nanomedicine

🟣 #Nanomedicine, #DrugDelivery, #Diabetes | 𝗖𝗮𝗻 𝗼𝗿𝗮𝗹 𝗶𝗻𝘀𝘂𝗹𝗶𝗻 𝗳𝗶𝗻𝗮𝗹𝗹𝘆 𝗿𝗲𝗽𝗹𝗮𝗰𝗲 𝗶𝗻𝗷𝗲𝗰𝘁𝗶𝗼𝗻𝘀? 𝘊𝘩𝘢𝘳𝘨𝘦-𝘳𝘦𝘷𝘦𝘳𝘴𝘪𝘣𝘭𝘦 𝘭𝘪𝘱𝘪𝘥 𝘯𝘢𝘯𝘰𝘱𝘢𝘳𝘵𝘪𝘤𝘭𝘦𝘴 𝘴𝘩𝘰𝘸 𝘱𝘳𝘰𝘮𝘪𝘴𝘦 𝘧𝘰𝘳 𝘦𝘧𝘧𝘪𝘤𝘪𝘦𝘯𝘵 𝘰𝘳𝘢𝘭 𝘪𝘯𝘴𝘶𝘭𝘪𝘯 𝘥𝘦𝘭𝘪𝘷𝘦𝘳𝘺. 📘 𝗔𝗶𝗺: 💊 Developing a pH-responsive, biocompatible lipid nanoparticle (LNP) system to enhance insulin absorption and stability for oral administration. 📊 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: 🔬 Insulin-loaded DOP-DEDA-LNPs remain stable in simulated gastrointestinal fluids for over 2 hours. 📈 Oral administration in diabetic mice led to a sustained 40% blood glucose reduction for more than 10 hours. 🛡️ Charge-reversible properties improve absorption in the intestine while minimizing toxicity at physiological pH. 📌 𝗧𝗮𝗸𝗲 𝗛𝗼𝗺𝗲 𝗠𝗲𝘀𝘀𝗮𝗴𝗲: 🚀 This novel LNP system could revolutionize insulin therapy, reducing the need for painful injections and improving patient compliance. Published in Biochemical and Biophysical Research Communications, Jan 2025. Read more: https://lnkd.in/eE9F9KPU Thank you to the authors: @Dai Oyama @Katsuki Matayoshi @Soya Kanetaka @Chiori Nitta Hiroyuki Koide @Keiko Minami @Tomohiro Asai 🔎 Could this be the breakthrough needed for oral insulin? Let’s discuss!👇 #OralInsulin #Biopharma #LipidNanoparticles #MedicalInnovation #Endocrinology

🟣It's always exciting to see NanoSphere making an impact! Thank you, Jake Brenner, for the kind words and for recognizing our mission—to bring nanomedicine science closer to the community in a meaningful way. #Nanomedicine #ScienceForTheCommunity