Applied Photophysics

Structural Insights into SLF1’s Role in Replication-Coupled DNA Repair and SMC5/6 Complex Recruitment using our Circular Dichroism Instrument 🔬 This study by the University of Leeds explores the structural mechanisms behind SLF1 (SMC5–SMC6 complex localization factor 1) interactions, which are essential for DNA damage repair at stalled replication forks. The researchers determined the crystal structure of SLF1's ankyrin repeat domain bound to an unmethylated histone H4 tail, revealing how SLF1 interacts with nascent nucleosomes. Using mutagenesis, they confirmed the importance of phosphorylation in SLF1’s interaction with RAD18, crucial for a stable complex. They also discovered that SLF1’s RAD18-binding interface has a DNA-binding property, further aiding the repair process. These findings provide new insights into how SLF1 facilitates the recruitment of the SMC5/6 complex during replication-coupled DNA repair. 📖 Learn More: https://lnkd.in/eWCrthwY Check out the Chirascan V100 used in this Publication: https://bit.ly/4eWBYzo #DNARepair #ReplicationForks #SLF1

🌟 Meet the Team: Maddy 🌟 Our "Meet the Team" series continues with Mohammad Shadab (Maddy), our Global Marketing Manager, whose impressive skills and dedication make him an invaluable part of Applied Photophysics! 💪About Maddy: 🔬 Forensic Expertise: Maddy is a trained Forensic Scientist and Crime Scene Investigator, certified in blood-spatter analysis. 🌍 Linguist: Fluent in reading, writing, and speaking four languages while understanding nine in total. 💙 Charity Work: Maddy has a strong commitment to global charities. Currently, he serves as a lay member of an advisory board at the British Thoracic Society, supporting initiatives to improve respiratory care and awareness. 🏏 Sports Enthusiast: A keen sportsman, Maddy plays cricket, hockey, tennis, table tennis, and snooker regularly. As a cricketer, he started his career as a fast bowler but has moved to batting over the years. He scored 443 runs last season with an impressive average of ~41 and a strike rate of 150. 💼 Why He Loves His Job: Maddy finds immense satisfaction in his work, knowing it positively impacts patient health, advances life sciences, and supports scientific discovery. He takes pride in collaborating with his outstanding team at Applied Photophysics. That’s it for this year’s features, but our "Meet the Team" series will return in the new year with even more stories about the talented individuals behind Applied Photophysics. Stay tuned! #MeetTheTeam #AppliedPhotophysics

We're thrilled to be attending the 12th MIBio Conference in Cambridge 🌟 Visit Rostand Hagouang Peka at our booth to learn how we can support your biopharmaceutical formulation needs! 📖 Learn More: https://lnkd.in/eD27zF6a See you there! 👋 #MIBio2024 #BiopharmaInnovation

We installed a new equipment for circular dichroism: Chirascan V100, replacing the old Jasco J-815. The Chirascan V100 offers higher sensitivity and an improved signal-to-noise ratio, better accommodating the measurement of biomolecules.

🌟 Meet the Team: Martin 🌟 This week, we’re excited to spotlight Martin Textor, Sales Support Applications Scientist, whose passion for creativity and collaboration makes him an essential part of the Applied Photophysics team! 💪About Martin: 🎵 Music Enthusiast: Martin enjoys listening to Progressive Rock, whether live or in the office, to keep his spirits high. 🍞 Comfort Food: Proper German dark rye sourdough bread is Martin’s favourite, a rare treat to find in Britain. 🛠️ Creative Hobbyist: In his free time, Martin loves crafting creative projects that often involve a CNC machine, Arduino electronics, programming—or sometimes all three! 💼 Why He Loves His Job: For Martin, the best part of his role is the variety it offers. One day might involve measuring samples in the lab, another could mean travelling for customer training, and the next might be spent programming, testing hardware, or creating marketing materials. Working alongside great colleagues across departments makes collaboration a constant and rewarding experience. Stay tuned for more stories about the talented individuals who drive Applied Photophysics forward! #MeetTheTeam #AppliedPhotophysics

Researchers from the University of Washington and Howard Hughes Medical Institute (HHMI) developed a GFP-based aspartate sensor, jAspSnFR3, to address the limitations of traditional mass spectrometry in measuring aspartate levels. The sensor exhibits a 20-fold fluorescence increase upon aspartate binding, covering physiologically relevant concentrations with high specificity. In mammalian cells, jAspSnFR3 accurately tracked aspartate levels and temporal changes caused by genetic, pharmacological, or nutritional manipulations. This innovative tool enables real-time, high-throughput studies of aspartate metabolism and its role in cellular function. 📖 Learn More: https://lnkd.in/eYQe4vSc Check out the SX20 used in this publication: https://bit.ly/3OmjnCc #AspartateMetabolism #Biosensor #FluorescenceImaging

🌟 Meet the Team: Cam Hick 🌟 In our “Meet the Team” series, we’re delighted to introduce Cam Hick, Business Development Manager, who brings dedication and a love for variety to her role at Applied Photophysics! 💪 About Cam: 🌅 Favorite Hobby: She loves starting the day with a peaceful walk along the beach at sunrise – the perfect way to recharge and connect with nature. 🥤 Comfort Drink: A Diet Coke is her go-to treat – refreshing and comforting all at once! 🗺️ Bucket List Accomplishment: She has raised two wonderful children and travelled widely – though there’s always more to explore! 💼 Why She Loves Her Job: With 9 years at Applied Photophysics, she values that no two days are ever the same. Working for a small company that contributes to scientific advancements around the world has been incredibly rewarding. Stay tuned as we continue to introduce more talented members of the Applied Photophysics team! #MeetTheTeam #AppliedPhotophysics #Spectroscopy

🌟 Meet the Team: James 🌟 Our "Meet the Team" series continues with James Law, Software Manager, whose love for adventure and hands-on work makes him a valued part of Applied Photophysics! 💪 About James: ⛷️ Favorite Activity: An avid skier, James tries to hit the slopes whenever he gets the chance, even though it’s not nearly as often as he’d like. 🍛 Comfort Food of Choice: Lamb Jalfrezi with garlic naan and a cold beer – the ultimate way for him to unwind. 🎶 New Skill: He is currently learning to play the accordion, which he admits is challenging, but he’s making great progress! 💼 Why He Loves His Job: James appreciates the hands-on work with diverse technologies and products that play a vital role in scientific research. He finds it especially fulfilling to support researchers in making meaningful discoveries. Working at a smaller company allows him to collaborate closely with other departments, and he values being part of a skilled, friendly team. Stay tuned for more insights from the talented individuals that make up our team! #MeetTheTeam #AppliedPhotophysics

We’re here at the 2024 Protein Sciences in Drug Discovery ELRIG UK meeting! 🎉 Join Markus Epe and Mohammad Shadab at Booth 15 today and tomorrow, 18th-19th November, at Hinxton Hall in Cambridgeshire. 📖 Learn More: https://lnkd.in/eqkjFVMC We look forward to meeting you! 👋 #ELRIG2024 #ProteinScience #DrugDiscovery

Busy day today at Protein Sciences in Drug Discovery 2024! 🙌 Protein Stable ELRIG UK The Protein Society