Medical Gas Research

Exploring the Efficacy of #HyperbaricOxygenTherapy for #TraumaticBrainInjury (TBI): A Deep Dive into 40 Sessions https://lnkd.in/gKQ_Fgmc Aviv Clinics Tel Aviv University In the latest issue of Medical Gas Research, a perspective titled "Why provide 40 sessions of hyperbaric oxygen therapy to patients with traumatic brain injury?" sheds light on the critical role of HBOT in treating TBI, a condition that has emerged as a significant clinical challenge, especially among war veterans. The severity of TBI is assessed based on patient presentation, including loss of consciousness and Glasgow Coma Scale score. It's a complex injury that can lead to both immediate and long-term cognitive and physical impairments. Understanding the pathophysiology of TBI is crucial for effective treatment, and HBOT has emerged as a promising therapy. HBOT involves exposing patients to 100% oxygen at higher than atmospheric pressure, which has been shown to increase oxygen supply, accelerate the washout of inert gases, and stimulate the growth of new blood vessels through angiogenesis. This therapy not only addresses the immediate oxygen crisis in TBI but also promotes neuroprotective and neuroregenerative effects, enhancing the body's natural healing processes. The article underscores the importance of a minimum of 40 HBOT sessions for TBI patients. This recommendation is based on physiological evidence that suggests the optimal timeframe for growing new blood vessels requires at least 6 weeks of daily treatment, aligning with the 40-session regimen. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #MedicalGas #NeurologicalRecovery

In the ever-evolving field of medical gas research, a perspective published in Medical Gas Research offers significant contributions to our understanding of hyperbaric hyperoxic lung injury. It delves into the effects of elevated oxygen partial pressure on lung health, a critical concern for divers and those in hyperbaric environments. https://lnkd.in/g-HbsaeR Lung Injury and Recovery: The study established an animal model by exposing rats to pure oxygen at 250 kPa for 6 hours, leading to acute lung injury characterized by lung edema and increased pro-inflammatory factors. Notably, lung function and blood gas parameters, except for PO2, PCO2, sO2, total carbon dioxide, and HCO3–, showed signs of recovery within 48 hours. Blood Gas Analysis: Immediately post-exposure, there was a significant increase in pH value, PO2, and oxygen saturation, alongside a decrease in PCO2. These changes underscore the impact of hyperbaric oxygen exposure on respiratory function. Histological Examination: The study observed thickening and rupture of alveolar septum, infiltration of inflammatory cells, and leakage of red blood cells, indicating significant lung injury. However, these manifestations improved to some extent a week after exposure, with no significant fibrosis observed. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #LungInjury #MedicalGas #HyperbaricMedicine #OxygenToxicity

The study, "Correlation of lung function with brachial artery function and cardiac function in divers after hyperbaric exposure", provides valuable insights into how divers' bodies adapt and respond to the extreme conditions they face underwater. It's a must-read for anyone interested in the physiological challenges of diving and the impact of decompression on human health. https://lnkd.in/gy28avEh Findings: Divers exposed to hyperbaric conditions showed significant changes in brachial artery diameter and systolic peak velocity. There was a tendency for a reduction in flow-mediated dilation, indicating potential vascular dysfunction post-exposure. Cardiac function parameters, such as left ventricular internal systolic diameter and pulmonary arterial velocity, tended to increase after exposure. Lung function largely remained unchanged, with some parameters showing unexpected trends compared to previous studies. The research underscores the importance of understanding how hyperbaric exposure affects divers' health, which is crucial for developing safer diving practices and decompression protocols to reduce the risk of decompression sickness. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #Diving #HyperbaricExposure #MedicalGas

Gas-related pathological events and therapeutic failures: a case of oxygen at the microcirculatory and lymphatic level https://lnkd.in/gdJaRjfQ University of Siena (Università degli Studi di Siena) The Importance of the Glycocalyx The GCX, a layer on the surface of our vascular endothelium, plays a multifaceted role in vascular functions, including mechanotransduction, acting as a molecular sieve, and providing a physical barrier. This article highlights how severe impairment of the GCX can lead to a variety of pathologies, such as sepsis, diabetes, and chronic kidney disease, due to its influence on oxygen transport. Innovative Therapeutic Approaches The study suggests that by understanding the GCX's role in gas transport, we can develop new therapeutic strategies. Hyperbaric oxygen therapy is one such approach that has shown promise in restoring the health of the GCX and improving oxygen transport, potentially revolutionizing the treatment of diseases associated with GCX damage. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #Glycocalyx #Oxygen #Microcirculation

The study, titled "Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports", presents a dual therapeutic approach that could significantly improve the quality of life for those undergoing hemodialysis. https://lnkd.in/ggqzr35n Findings: Fatigue is a debilitating symptom for hemodialysis patients, linked to higher risks of death, cardiovascular disease, and depression. The study explores the use of molecular hydrogen (H2), known for its antioxidant properties, to reduce oxidative stress and alleviate fatigue. Two patients with end-stage renal disease underwent a combined therapy of H2 gas inhalation and H2-enriched dialysate, showing remarkable improvements in fatigue levels and quality of life. Impact: The median SONG-HD fatigue score dropped from 9 (maximum fatigue) to 0 (no fatigue) after the combined therapy, indicating a significant reduction in fatigue. Patient-reported outcomes, including the Euro-Qol Visual Analog Scale (EQ-VAS), showed substantial improvements, reflecting better health and well-being. The study suggests a reduction in post-dialysis serum levels of citrullinated histone H3 (CitH3), a specific biomarker for neutrophil extracellular trap (NET) formation, which is central to inflammation and endothelial damage. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #Hemodialysis #Fatigue #Medicalgas

Unlocking the Potential of Molecular Hydrogen Gas in Modern Medicine Yonsei University A recent article in Medical Gas Research explores the therapeutic potential of molecular hydrogen (H2) gas, a promising candidate in the field of medicinal gases. https://lnkd.in/gbht_yJA H2, known for its antioxidant and anti-inflammatory properties, has shown potential in managing a spectrum of diseases, from neurodegenerative conditions to cardiovascular disorders. Its ability to penetrate cell membranes and reach cellular compartments positions it as a unique therapeutic agent. Key findings: Neuroprotection: H2 has demonstrated the capacity to cross the blood-brain barrier, reducing oxidative stress in neural tissues and showing promise in models of Alzheimer's and Parkinson's diseases. Cardiovascular Health: By lowering oxidative stress in blood vessels and improving endothelial function, H2 could offer a novel approach to treating cardiovascular diseases, a leading cause of global morbidity and mortality. Respiratory Diseases: H2's anti-inflammatory effects in the lungs make it a potential therapeutic option for conditions like ARDS and COPD, where inflammation plays a critical role in disease progression. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #HydrogenGas #Therapy

Carbon monoxide inhalation as a potential aid to enhance aerobic endurance https://lnkd.in/gjCK8MAk The perspective published in Medical Gas Research explores the effects of controlled carbon monoxide (CO) exposure on aerobic performance. It's a deep dive into how a gas once known primarily for its dangers might hold the key to improving VO2max and endurance in athletes. Findings: The research indicates that low doses of CO can positively influence biological processes, including inflammation modulation, oxidative stress reduction, and even the regulation of mitochondrial biogenesis and angiogenesis. These effects suggest that CO could be more than just a byproduct of combustion-it could be a performance booster. Protocol: The study outlines a specific protocol for CO inhalation, suggesting that a regimen of at least 5 days a week for 4 weeks, with each session lasting at least 2 minutes at a dose of at least 1 mL/kg, could significantly enhance aerobic endurance. This is not a casual endorsement but a carefully measured approach that echoes the effects of high-altitude training. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #CO #EnhanceAerobic #SportsScience

Hydrogen sulfide: a rising star for cancer treatment https://lnkd.in/g6fbmSVV GSMs like nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are being investigated for their therapeutic potential. These molecules are known for their rapid metabolism and ability to diffuse quickly at the lesion site, offering a new avenue for targeted anti-tumor therapy. H2S, in particular, has shown promise in stimulating cytoprotective pathways and increasing mitochondrial function at low concentrations, while at higher concentrations, it can inhibit cancer cell metabolism and induce apoptosis. Nanomedicines and Controlled H2S Delivery Researchers are developing nanomaterials that can deliver H2S in a controlled manner, minimizing potential toxicity and maximizing therapeutic effects. This includes the use of organic synthetic H2S donors, natural organic sulfides, and inorganic sulfide salts. The challenge lies in site-specific delivery and controlled release of H2S, ensuring that the gas is transported to the lesion site within an effective therapeutic concentration range. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. #CancerResearch #H2S

Professional Update: Exploring Nitric Oxide in Glaucoma Treatment Albert Einstein College of Medicine In the latest issue of Medical Gas Research, an article titled "Not a laughing matter: revisiting nitric oxide as a potential target for glaucoma therapy" offers a compelling look into the role of nitric oxide in managing glaucoma, a leading cause of irreversible blindness. Nitric Oxide's Role in Glaucoma: Nitric oxide, synthesized by nitric oxide synthase, is crucial for maintaining vasodilation and has shown potential in reducing intraocular pressure, a critical factor in glaucoma treatment. The article highlights the use of L-arginine, a semi-essential amino acid and precursor to nitric oxide, which could be particularly beneficial for the African American population, who are at a higher risk of glaucoma and have lower L-arginine levels. The Impact on Health Disparities: The research suggests that supplementary L-arginine could increase endothelial function and potentially improve outcomes for African Americans, who are disproportionately affected by glaucoma. This insight could help bridge health disparities and offers a targeted approach to treatment. Therapeutic Potential: The article discusses various classes of glaucoma therapies that act as nitric oxide donors, including prostaglandin analogs, β-blockers, and carbonic anhydrase inhibitors. These treatments show promise in reducing intraocular pressure and could revolutionize glaucoma management. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. https://lnkd.in/gf9ARYAy #Glaucoma #NitricOxide

Innovative Treatments in Oncology: The Potential of Cold Atmospheric Plasma (CAP) in Breast Cancer Therapy Universidade de Coimbra Mafalda Laranjo A fascinating article from Medical Gas Research explores the cutting-edge use of cold atmospheric plasma in the treatment of breast cancer. The perspective, titled "Cold atmospheric plasma for breast cancer treatment: what next?" delves into the promising results and future directions of this novel therapy. Understanding Breast Cancer: With the highest incidence rate globally, breast cancer is a leading cause of death among women. Treatment strategies have evolved, but challenges remain, including therapeutic resistance and side effects. Introducing Cold Atmospheric Plasma (CAP): CAP, a form of non-thermal plasma, is being investigated for its potential to selectively target and destroy cancer cells. It operates by generating reactive species, ultraviolet light, and electromagnetic fields, which can induce oxidative stress in cancer cells, leading to cell death. Mechanisms of Action: The article discusses how CAP affects cancer cells at the molecular level, including the disruption of the actin cytoskeleton, downregulation of proteins associated with metastasis, and induction of apoptosis. CAP also shows potential in sensitizing drug-resistant cells to traditional therapies. Combining CAP with Existing Therapies: CAP's potential to enhance the efficacy of established treatments, such as chemotherapy and immunotherapy, is a significant area of exploration. This could lead to reduced treatment resistance and fewer side effects for patients. About the Journal: Medical Gas Research is indexed in MEDLINE, Emerging Sources Citation Index, PubMed and etc. 2023 JCR IF: 3.0, Q2 in MEDICINE, RESEARCH & EXPERIMENTAL. https://lnkd.in/gJYREi8n #BreastCancer #ColdAtmosphericPlasma