Nanodigmbio Biotechnology

Ultra-Sensitive Probe Hybridization Capture System (μCaler® Hybrid System) Compared to traditional liquid-phase hybridization capture technology, the μCaler® Hybrid System, a globally exclusive patented technology by Nanodigmbio, utilizes non-equilength probes (20-100 nt). Through the conjugation effect between probes, it enhances the enrichment capability of adjacent probes for target regions, enabling more efficient and stable capture of methylation and mutation signals in samples, thereby facilitating multi-omics analysis. #Hybridization#NGS#Patent

Instrumentation + Automation | Nanodigmbio NadAuto-16！ 【Product Introduction】 NadAuto-16R is a versatile automated system featuring a 3D robotic arm, liquid handling module, temperature control, thermal cycling, and heating/oscillation capabilities. It includes 12 standard SBS plate positions, allowing flexible configuration of modules and consumables to suit various applications and sample volumes. With 8-channel pipetting tips and a plate gripper, it efficiently handles tasks like sample dispensing, nucleic acid extraction, enzyme reactions, purification, and mixing. Additionally, it supports automated gene sequencing library preparation and hybridization capture, significantly enhancing laboratory productivity. #NGS#Automation#Insrtument To learn more, click the link below https://lnkd.in/ege9pMr3

👏 Unafraid of BS conversion damage, achieving both higher yield and depth! The newly upgraded NadPrep® Methyl Library Preparation Module v2 is suitable for methylation library construction from 1-500 ng of DNA. It supports whole-genome methylation sequencing and is compatible with liquid-phase hybridization targeted capture sequencing, enabling targeted methylation sequencing library enrichment. Additionally, the upgraded version is suitable for various types of DNA samples, including gDNA, cfDNA, and FFPE DNA, and is compatible with the main conversion methods available on the market. Building on version 1, version 2 reduces experimental time, supports lower sample input amounts, and significantly improves library yield and effective data utilization, providing users with a more efficient, flexible, and reliable methylation sequencing solution. Features of the Protocol- 1.Lower sample input amount: Reduced from 10 ng to as low as 1 ng. Faster library preparation process: Shortened from 3 hours to 2.5 hours* 2.Higher library yield: Significant increase in library output across different application scenarios compared to version 1. 3.Higher data utilization: Compared to version 1, the effective sequencing depth is higher, reaching the forefront of similar library preparation kits. 4.Flexible choice of different conversion methods: Bisulfite conversion (BS) & enzymatic conversion (EM). 5.Compatible with dual sequencing platforms: After connecting different adapters, it can be applied to both Illumina & MGI sequencing platforms. *Does not include conversion time. #NGS

DDR Mutations May Open New Doors for Companion Diagnostics! Recently, a study titled "DNA damage response and repair gene mutations are associated with tumor mutational burden and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients" was published. The research found that in NSCLC patients without EGFR and ALK mutations, DDR gene mutations are closely associated with tumor mutational burden (TMB), prognosis, and response to platinum-based chemotherapy/immunotherapy. Nanda provided the reagents for next-generation sequencing library construction and hybridization capture, laying the foundation for this part of the experimental testing. In this study, DNA was extracted from tissue FFPE samples, plasma ctDNA, and blood lymphocyte gDNA. After library construction and target capture, paired-end sequencing was performed on the Illumina NovaSeq 6000 platform. It is noteworthy that the library construction kit (NadPrep DNA Library Preparation Kit) and the target capture kit (NadPrep Hybrid Capture Reagents) used in this study were all provided by Nanodigm. Summary: This is the first systematic study to explore the impact of DDR gene mutations on the prognosis and response of NSCLC patients without EGFR and ALK mutations to platinum-based chemotherapy and immunotherapy. DDR gene mutations hold potential as a prognostic biomarker for NSCLC patients undergoing platinum-based chemotherapy/immunotherapy, potentially opening new avenues for companion diagnostics. Original Link: DNA damage response and repair gene mutations are associated with tumor mutational burden and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients - Diagnostic Pathology If you are also involved in related research, we would be honored to recommend our products to you. If you are interested, please leave a message below.#NGS

🤔"With such high throughput of the sequencer, how can I ensure my libraries are properly separated?"Nanodigmbio: "🤭Is 768 enough?" 👍 Nanodigmbio previously launched an exclusive, patented dual-platform (Illumina & MGI) universal adapter module-the NadPrep® Universal Stubby Adapter (UDI) Module-which comes with 384 sets of Indexes. Libraries constructed using this adapter module are not only compatible with Illumina platforms for sequencing but can also be directly circularized for use on MGI platforms without the need for App-A conversion. This significantly reduces the time cost of sequencing and has been highly praised by users! 👏 After rigorous quality control and careful selection and optimization, Nanodigmbio has now expanded and upgraded the Index types in this module, increasing the combination number to 768. This upgrade aims to better meet the market's expectations for higher throughput needs!#NGS#Index If you need anything, please leave a message below! 🤓

Nanodigmbio invites you to join us at the 2024 American Society of Human Genetics (ASHG) Annual Meeting in Denver! 💁♂️ Introduction to the Conference:The 2024 American Society of Human Genetics (ASHG) Annual Meeting is currently taking place in Denver, Colorado, USA. Established in 1948, ASHG aims to lead in the research, education, and service of human genetics. Since its inaugural event in 1948, the ASHG Annual Meeting has grown to become the world's largest conference on human genetics and genomics, attracting over 8,000 attendees each year. 👏 Recommendations for Nanodigmbio-related products. 1.μCaler multi-scenario application solutions. 2.Personalized probe customization service. 🙌 Nanodigmbio time: [Exhibition Dates] November 05 - 09, 2024 [Exhibition Venue] Colorado Convention Center, Denver, Colorado, USA [Nanodigmbio Booth] 257 If you have any needs, please feel free to leave us a message!

Recently,  we will launch a new plate-based packaging reagent tailored for NadAuto-16R, applicable to pre-library construction and hybridization capture, to further shorten reagent preparation time and optimize the operational experience. This design preloads all reagents into standard plates, significantly reducing manual placement and pipetting operations. This not only effectively reduces the risk of human error but also significantly improves experimental efficiency, enabling users to perform automated operations more smoothly. Subsequently, we will continue to launch more plate-based packaging reagent processes. Stay tuned!#NGS #Automation #DNAcap #RNAcap #MethyIcap

The #Nanodigmbio NGS automation system are fully equipped with scripts and reagents for DNA/RNA, methylation library preparation, and whole capture procedures, making it a true "click-to-start" system. We offer a one-stop solution that includes the automation machine, NGS reagents, and applications. Feel free to contact us for more details! #NGS #Automation #DNAcap #RNAcap #MethyIcap

A new study reveals that 15% of colorectal cancers have defects in the homologous recombination pathway, making them potentially responsive to PARP inhibitors. The HRDirect tool, developed to predict HR deficiency, outperformed other assays in distinguishing PARPi-sensitive CRC models. Combining HRDirect with immunohistochemical analysis of ATM and RAD51C could improve identification of HRD tumors, offering a significant advance in personalized CRC treatment. The full text link: https://lnkd.in/gRTEE4aT #CancerResearch #PARPi #CRC #NGS #Biomarkers