Bioelectrodynamics research team

🌟 Webinar Reminder 🌟 Kindly note that today’s webinar will not be recorded. We look forward to seeing you there! 📈📊📰👇https://lnkd.in/e4keYtbg

🚨 Webinar Alert 🚨 Join us for our 34th webinar on Monday, Nov 25, at 14:00 CET! 🎙️ Speaker: Angela Stelson from the NIST 🔬 Topic: #Microwave #Microfluidics for Chemical and Biological Applications Register here: https://shorturl.at/18zv6 Engineering in Medicine and Biology, Chapter of CS IEEE MTT-28 Bio-Effects and Medical Applications Committee IEEE Region 8 (Europe, Middle East & Africa) IEEE Engineering Medicine and Biology Society IEEE International Union of Radio Science (URSI)

🚨Good news🚨: Our 33rd webinar is already on YouTube 👉https://lnkd.in/e_sqgBCY

🚨 Webinar Alert 🚨 Join us for our 33rd webinar on Monday, Nov 11, at 10:00 CET! 🎙️ Speaker: Rui Wang from Foshan University 🌱 Topic: Research Progress of #PEF Technology in Plant #Protein Modification Register here: https://shorturl.at/xpQsz Engineering in Medicine and Biology, Chapter of CS IEEE MTT-28 Bio-Effects and Medical Applications Committee IEEE Region 8 (Europe, Middle East & Africa) IEEE Engineering Medicine and Biology Society

🖥️⚡🧪We used molecular dynamics simulations to show that intense electric fields (EF) can detach the kinesin motor from its microtubule track, with detachment effectiveness depending on EF strength and direction. The X EF direction was most effective, and we found that EF primarily affects kinesin detachment by acting on the β-tubulin C-terminus charge and kinesin's dipole moment. We also developed a model to explain detachment rates based on EF strength, providing insights for future research and potential applications in bionanotechnology. For more information, see the article below: 🔍👇 https://lnkd.in/d58s58qt #compchem #ElectricForces Institute of Photonics and Electronics, Czech Academy of Sciences Akademie věd České republiky

⚡🖥️🧪 We investigated how the direction of the electric field (EF) affects the kinesin-tubulin interaction, focusing on the four EF directions perpendicular to the kinesin-tubulin connection axis (X, -X, Z, -Z) at 100 MV/m field strength. This choice was based on our prior experience with molecular dynamics simulations, as this EF strength is comparable to the effective EF in cell membranes. For more information, see the article below: 🔍📃👇 https://lnkd.in/d58s58qt #compchem #ElectricForces #nanomotors #MDsimulations Akademie věd České republiky Institute of Photonics and Electronics, Czech Academy of Sciences

⚡🖥️🧪We explored a novel method for controlling the #kinesin motor protein using electric forces, bypassing the limitations of chemical modifications. Through full-atom #MD simulations, we demonstrated that a strong electric field can detach kinesin-1 from #microtubules within nanoseconds. Our results contribute to understanding of EF–biomatter interactions on a molecular level, with potential #biomedical and #nanotechnological applications for harnessing control of #protein #nanomotors. For more information, see the article below: 🔍👇 https://lnkd.in/d58s58qt #compchem #ElectricForces Akademie věd České republiky Institute of Photonics and Electronics, Czech Academy of Sciences

📢✨We welcome our new #intern Sukesh Tallapudi - @Sukesh49372239, who will engage with us in #MD modeling of #electric field effects on #proteins! Great to have you on board, Sukesh, welcome!🤝🖥🧬

⚡🧪🖥️We analyzed how the time required for #kinesin detachment decreases with increasing #ElectricField (EF) strength, showing that a higher EF lowers the activation energy barrier for detachment. Using the #Arrhenius equation, we quantified the interaction term that describes how the EF couples with the system to lower this barrier. Our simulations showed that EF-induced rotational and translational work play key roles in the detachment process, with the interaction term being lower in simulations than in analytical estimates. For more information, see the article below: 🔍📃👇 https://lnkd.in/d58s58qt #compchem #ElectricForces #nanomotors #MDsimulations Akademie věd České republiky Institute of Photonics and Electronics, Czech Academy of Sciences

⚡🧪🖥️We investigated how #ElectricField (EF) strength affects #kinesin detachment by running #simulations at various strengths (30, 50, 75, and 100 MV/m). We found that detachment slows and becomes more unpredictable as EF strength decreases. While the EF strength significantly affects the #DipoleMoment (DM) magnitude and angle, it is the change in kinesin DM angle, rather than magnitude, that plays a crucial role in detachment. The rotational work on kinesin and translational work on the β-#tubulin C-terminus are both important, with rotational work decreasing at lower EF strengths. For more information, see the article below: 🔍📃👇 https://lnkd.in/d58s58qt #compchem #ElectricForces #nanomotors #MDsimulations Akademie věd České republiky Institute of Photonics and Electronics, Czech Academy of Sciences