CapCo Bio GmbH

When discussing siRNA delivery, it's crucial to emphasize that the design of the siRNA itself is just as important as the delivery systems. Here are some key dos and don'ts for designing effective siRNA: ✅ 𝐃𝐎'𝐬: To prevent unspecific or weak binding to the target mRNA and to allow unwinding and RISC (RNA-induced silencing complex) incorporation: - Ensure the GC content of your siRNA is around 30 - 60%. - To ensure preferential loading of the antisense strand: - Design siRNAs with asymmetrical nucleotide content. - Ensure weak base pairing at the 5'-end of the antisense strand. ❌𝐃𝐎𝐍'𝐓𝐬: General features to avoid to prevent off-target effects or poor target mRNA binding: - Avoid secondary structures in the sense or antisense strand. - Avoid repetitive CCC or GGG sequences. - Ensure no miRNA seed matches. - Avoid sequences known to be toxic. To prevent activation of the immune system: - Avoid specific recognition sequence patterns. - High uridine content can trigger immune responses. - Ensure the dsRNA length is ≤ 30 bp. - Effective siRNA design is a balance of precision and functionality.   #siRNA #biotechnology #genetherapy #rnainterference #biotech #research #lifesciences #innovation

Thrilled to share an insightful publication on the exciting advancements in nucleic acid-based therapies! As the third major drug class, following small molecules and antibodies, these therapies are proving their potential with recent regulatory approvals and tremendous clinical successes. This review covers: 🌟Major challenges the field has faced 🌟Historical milestones achieved 🌟Innovations driving current capabilities 🌟Future developments on the horizon Read more =>https://lnkd.in/gXcW3Dhu 🔬    #NucleicAcidTherapies #Biotech #PharmaInnovation #GeneTherapy #FutureOfMedicine

Ah, Q4—the most wonderful time of the year! 🎶 Or is it? As the end of the year approaches, many of us in the business world are starting to feel that familiar Q4 crunch. Deadlines are looming, targets need to be met, and holiday distractions are lurking just around the corner. It's a time of year that can be both exhilarating and downright panic-inducing!   How do you handle the Q4 rush? Share your tips and experiences in the comments below—and maybe a funny meme or two to lighten the mood! 😄   #Q4Panic #EndOfYearRush #BusinessGoals #TeamWork #StayMotivated

🧬👻 Wishing everyone a Halloween full of fun surprises and just the right amount of fright.  Happy Spooky Halloween! #HappyHalloween #ScientificallySpooky #Biologists

🌟 World CRISPR Day: a journey through genetic innovation 🌟   🔬 CRISPR-Cas Systems - The marvels of modern science! Known as acquired immunity systems in archaea and bacteria, these RNA-guided nucleases are the most reliable tools for genome editing and engineering. 🧬✨   📜 A Glimpse into History: 1987 marked a groundbreaking discovery when an unusual repetitive DNA sequence, later named CRISPR, was found in the Escherichia coli genome. This sparked a revolution in genetics. 🌱🔍   🌍 Universal Patterns: Soon, similar sequences were identified in various bacteria and halophilic archaea, highlighting the significance of these conserved clusters. 🌐🔗   🔗 Connecting the Dots: The critical breakthrough came with linking CRISPRs to Cas proteins, initially thought to aid DNA repair in hyperthermophilic archaea. 🧩🔧   🧬 Revolutionary Tools: Thanks to comparative genomics, structural biology, and advanced biochemistry, we now have powerful genome editing tools like CRISPR-Cas9. This has revolutionized our understanding of genetic engineering and the evolution of mobile genetic elements called casposons. 🚀🔬   Did you know that 𝐂𝐀𝐏𝐒𝐔𝐋𝐎𝐍 technology can be used as a vehicle to deliver the CRISPR-cas system into cells? 🌟 𝐆𝐞𝐭 𝐢𝐧 𝐭𝐨𝐮𝐜𝐡 𝐭𝐨 𝐥𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐨𝐮𝐫 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐬 𝐚𝐧𝐝 𝐡𝐨𝐰 𝐰𝐞 𝐜𝐚𝐧 𝐜𝐨𝐥𝐥𝐚𝐛𝐨𝐫𝐚𝐭𝐞! 🌟   #WorldCRISPRDay #GeneticEngineering #Biotechnology #GenomeEditing #CRISPR #ScienceInnovation #HistoryOfScience #Breakthroughs #CAPSULON

🚨The Festival of Biologics in Basel is in full swing, don't miss the chance to:   🔹 𝐌𝐞𝐞𝐭 𝐂𝐚𝐩𝐂𝐨 𝐁𝐈𝐎: We're here to chat, collaborate, and share our latest innovations in gene delivery. 🔹 𝐂𝐡𝐞𝐜𝐤 𝐨𝐮𝐭 𝐨𝐮𝐫 𝐩𝐨𝐬𝐭𝐞𝐫: Explore the cutting-edge research and advancements we're showcasing. 🔹 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐧𝐞𝐰 𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐬: Learn how Capcobio can drive your projects forward with 𝐂𝐀𝐏𝐒𝐔𝐋𝐎𝐍 technology.   📍 𝐖𝐡𝐞𝐫𝐞 𝐭𝐨 𝐟𝐢𝐧𝐝 𝐮𝐬: Stop by our booth S02 to say hello and see what we’ve been working on. Let's make the most of these last days! See you at the festival!   #FestivalOfBiologics #Capcobio #GeneDelivery #Biotech #Innovation #LiveEvent #Networking #CAPSULON

We’re pumped to share that CapCo Bio GmbH will be at the Festival of Biologics this year!  🗓 𝐖𝐡𝐞𝐧? October 15-17, 2024 📍 𝐖𝐡𝐞𝐫𝐞? Beautiful Basel, Switzerland  If you’ve ever wanted to chat face-to-face with the CapCo Bio team, this is your chance! Swing by our booth to meet our experts, geek out over the latest in gene delivery tech, and see how we can help push your projects to the next level.   We’re all about making connections and sharing knowledge, so whether you're an industry veteran or just curious about what we do, we’d love to meet you. Let’s innovate, collaborate, and maybe even share a few laughs along the way!   #FestivalOfBiologics #Capcobio #GeneDelivery #Biotech #Innovation #LetsConnect

We’re pumped to share that CapCo Bio GmbH will be at the Festival of Biologics this year!  🗓 𝐖𝐡𝐞𝐧? October 15-17, 2024 📍 𝐖𝐡𝐞𝐫𝐞? Beautiful Basel, Switzerland  If you’ve ever wanted to chat face-to-face with the CapCo Bio team, this is your chance! Swing by our booth to meet our experts, geek out over the latest in gene delivery tech, and see how we can help push your projects to the next level.   We’re all about making connections and sharing knowledge, so whether you're an industry veteran or just curious about what we do, we’d love to meet you. Let’s innovate, collaborate, and maybe even share a few laughs along the way!   #FestivalOfBiologics #Capcobio #GeneDelivery #Biotech #Innovation #LetsConnect

Lab life adventures: ChatGPT vs. Protocol Books 🔬📚 In the fast-paced world of scientific research and development, efficiency and innovation are paramount. Leveraging advanced AI tools can significantly enhance our lab operations and research capabilities. While AI like ChatGPT is great for quick answers and brainstorming, some things are just better the classic way. The big question still remains, when to use: 🧠 ChatGPT: - Summarizing complex research papers - Drafting emails and reports - Getting quick insights or troubleshooting tips 📖 Protocol Books: - Following detailed experimental procedures - Ensuring consistency and accuracy in experiments - Training new lab members on standard practices Here’s to a balanced approach with more organized and less chaotic lab days! 😂🔬 How do you balance using AI tools and traditional methods in your lab? Share your experiences in the comments below! ⬇️   #LabLife #ScienceHumor #ProtocolProblems #ResearchLife #ChatGPT #AIInScience #OrganizedChaos

Did you know that #OnThisDay in 1905 a true scientific trailblazer was born? 🧬✨ Severo Ochoa (1905-1993), a name that resonates in the annals of molecular biology, was born on September 24th. His work has profoundly influenced our understanding of genetics and biotechnology. In 1959, his contributions were recognized with the Nobel Prize in Physiology or Medicine, which he shared with Arthur Kornberg.   🔬 Here are some of his incredible achievements: 𝐑𝐍𝐀 𝐒𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐬 𝐌𝐚𝐬𝐭𝐞𝐫𝐲: Ochoa's research demystified how RNA is synthesized, an essential process for decoding genetic information. 𝐄𝐧𝐳𝐲𝐦𝐞 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: He identified polynucleotide phosphorylase, an enzyme crucial for RNA synthesis, which has been instrumental in genetic research. 𝐆𝐞𝐧𝐞𝐭𝐢𝐜 𝐂𝐨𝐝𝐞 𝐂𝐫𝐚𝐜𝐤𝐢𝐧𝐠: His work helped decipher how genetic information translates into proteins, a cornerstone of genetic engineering and biotechnology.   🌟 Why Does This Matter? Ochoa’s discoveries are not just historical footnotes. They are the bedrock of many modern advancements in genetics and medicine. His work enables the genetic testing, therapies, and innovations that save lives and enhance our understanding of biology every day.   #SeveroOchoa #RNARevolution #GeneticsPioneer #BiotechInnovation #ScientificLegacy #NobelLaureate