Evotec

Meet our team and learn about our research at #SLAS2025 in San Diego https://hubs.ly/Q032dcNB0. Mélanie Carquin PhD, Team Leader in Evotec’s HTP Biology & Screening group will be presenting research on RNA splicing modulators and their role in drugging ‘undruggable’ targets. To learn more about our research, schedule a meeting with our experts at booth #850 by contacting info@evotec.com. #hitidentification #undruggabletargets #splicingmodulators #DrugDiscovery

Just - Evotec Biologics has taken a significant step towards leveraging AI and ML for biopharmaceutical discovery by creating a Humanoid Antibody Library. In our latest publication, we describe the validation of this library by isolating antibodies against a target of pandemic concern, SARS-CoV-2. We successfully identified a panel of human monoclonal antibodies that are novel, diverse, and pharmacologically active. These first-generation antibodies exhibited neutralization of SARS-CoV-2 viral infectivity across multiple strains and indicated high developability potential. These results demonstrate the applicability of our platform for effective therapeutic antibody discovery. Read more here- https://hubs.ly/Q02SjSzQ0 #MachineLearning #AI #Biopharmaceuticals #Therapeutics #SARSCoV2 #AntibodyDiscovery #JustEvotecBiologics

We are thrilled to announce the release of our latest scientific paper: "Real World Applications and Experiences of AI/ML Deployment for Drug Discovery". This work represents a significant milestone in the integration of artificial intelligence (AI) and machine learning (ML) within the field of medicinal chemistry. Key Highlights: - Innovative AI/ML Techniques: We explore the deployment of cutting-edge AI/ML methodologies in drug discovery, from early target identification to lead optimization. - Collaborative Efforts: Our paper showcases the collaborative efforts of our talented team across multiple locations, including the UK, France, Italy, and the US. - Real-World Impact: We discuss the practical applications and challenges of integrating AI/ML in drug discovery, emphasizing the importance of blending human expertise with advanced computational tools. - Future Perspectives: Insights into the future of AI in medicinal chemistry and its potential to revolutionize the drug discovery process. This paper is a testament to our commitment to innovation and excellence in the field. We believe that the integration of AI/ML technologies will continue to drive significant advancements in drug discovery, making treatments more effective and accessible. Read it here- https://hubs.ly/Q032d6-P0 #AI #ML #DrugDiscovery

Our J. MD™ Molecular Design service helps derisk CMC efforts by helping biopharma companies select an optimal lead candidate and optimize the molecular design of biologics to ensure manufacturability, stability, and efficacy from the earliest stages of development. How? Read our blog to find out: https://hubs.ly/Q02SFGrD0 Contact us: info@evotec.com #JustEvotecBiologics #ContinuousBiomanufacturing #Developability #Preclinical

Our drug discovery experts will be traveling to #SLAS2025 in San Diego this month. Group leader of Evotec's In Vitro Biology department, Kamran Honarnejad, PhD, is chairing a session on Functional Genomics, co-chairing the Omics/Spatial Omics track, and presenting research and case studies on integration of CRISPR screening with high-dimensional readout technologies for target identification and validation. Learn more about our research presented at SLAS2025 here - https://hubs.ly/Q031qtcM0. Schedule a meeting with our experts at booth #850 by contacting info@evotec.com. #SLAS2025 #CRISPR #TargetIdentification #TargetValidation #DrugDiscovery

Our Chief Scientific Officer, Cord Dohrmann recently spoke to Reda Guiha, Country President of Pfizer in France, about our multi-year master research collaboration with Pfizer focusing on early discovery research for metabolic and infectious diseases. The research will be carried out at Evotec's state-of-the-art site in France. We are looking forward to the continued collaborating in the new year. To learn more about the partnership, read the full press release here- https://hubs.ly/Q031Jw7G0 #DrugDiscovery #TogetherForMedicinesThatMatter #MetabolicDisease #InfectiousDisease

Missed our recent virtual roundtable on "Antibody Design to Support Global Health Initiatives"? No worries! You can now watch the on-demand recording and gain valuable insights from leading experts in the field. Why Watch? - Discover cutting-edge strategies in antibody design. - Learn how these innovations are driving global health initiatives. - Hear from top scientists and industry leaders. Event Highlights: - In-depth discussions on the latest advancements. - Real-world applications and case studies. - Interactive Q&A sessions with the experts. Don't miss out on this opportunity to expand your knowledge and contribute to global health solutions. Click the link below to access the recording: Watch Now- https://hubs.ly/Q031qD9P0 Let's work together to make a difference! #GlobalHealth #AntibodyDesign #Innovation #Healthcare #JustEvotecBiologics

Meet Bernhard: Driving Innovation in Software Engineering at Evotec! We’re thrilled to continue our Employee Stories Series with Bernard, a talented software engineer at Evotec who is playing a crucial role in shaping the future of healthcare through technology. Bernhard’s story highlights: 🔹How his software engineering expertise fuels innovation at Evotec 🔹The impact of staying curious and constantly learning in tech 🔹The role of software in advancing healthcare breakthroughs and improving patient outcomes At Evotec, our software engineers like Bernhard are at the heart of transforming how we approach research, collaboration, and medicine. Bernhard’s story is a perfect example of how curiosity, creativity, and coding are paving the way for a healthier future. Watch the first part of Bernard’s story below and discover what #beCUREious means to him. Stay tuned as we share more Employee Stories, highlighting the inspiring journeys and the amazing work happening behind the scenes! Explore more on our website- https://hubs.ly/Q031Fvws0 #beCUREious #ResearchNeverStops #EmployeeExperience #EmployerBranding #HumanResources #innovation #LifeSciences #technology #creativity #Future #SocialMedia

Curious about how Evotec is leveraging AI to uncover hidden biology through genetic perturbation screening and cutting-edge cell imaging technology? Let's dive in! Evotec’s In Silico R&D scientists Andrei Zinovyev, Holger Henning, Arne Monsees, Rahul Valiya Veettil, William G. Charles, and Tim James partnered with Anne Carpenter and Shantanu Singh’s group at the Broad Institute of MIT and Harvard to analyze the novel JUMP Cell Painting Consortium genetic subset. This study combined genome-wide genetic perturbation screening - knocking out and overexpressing genes - and Cell Painting imaging with AI/ML models to uncover previously unknown aspects of human biology. Using biomedical knowledge graphs, Evotec developed deep learning models to predict gene functions, explain similarities in morphological profiles, and identify those that cannot be explained with current knowledge. These efforts uncovered new biological insights, revealing connections between mechanisms that were previously thought to be unrelated. This study demonstrates how combining high-throughput cell imaging with AI/ML can help researchers to unravel the complexity of biological systems. At Evotec, both Cell Painting and knowledge graph technologies are part of the core integrated drug discovery pipeline, providing insights into the effect mechanisms of action of potential drugs and their targets. Read more about the MorphMap study in the new preprint https://hubs.ly/Q031qHS00 on bioRxiv!

Wishing you a joyful holiday season filled with warmth, happiness, and bright new beginnings. From all of us at Evotec, happy holidays and a wonderful new year! 🎄✨