FLUIGENT Deutschland GmbH

🧬The Importance of Shear Stress in Cell Biology🧬 In typical in-vitro experiments, cells are cultured in static conditions, failing to replicate the dynamic environment of living organisms. However, shear stress from fluid flow plays a crucial role in cell behavior: 🔬 Mechanical Stimulation – Shear stress promotes cell elongation and alignment, particularly in endothelial cells. 🩸 Endothelial Cell Response – Cytoskeletal remodeling under shear stress supports vascular homeostasis and angiogenesis. 🎗 Cancer Cell Dynamics – Shear stress influences metastatic processes, including extravasation and migration. 📊 Tissue-Specific Modeling – Shear stress levels vary across tissues, making it essential for precise in-vitro modeling. Integrating shear stress into cell culture systems enhances experimental accuracy and physiological relevance. For physiological shear stress values in different organs and learn more about shear stress visit our website: https://lnkd.in/dAY9-sHc #CellBiology #ShearStress #OOAC #BiomedicalReseach

How Can You Efficiently Produce 1-10 µm PLGA Microbeads?💡 PLGA microspheres are ideal for controlled drug release and encapsulation due to their biodegradability, biocompatibility, and tunable release profiles.🌱 Secoya Technologies and Fluigent have combined their expertise to produce uniform PLGA microparticles ranging from 1 to 10 µm with exceptional monodispersity (CV = 2.4%). 🎯 This is made possible by Secoya's RayDrop, with its unique 3D design for precise droplet formation, and our FlowEZ and Flow Unit, ensuring high flow stability and high responsiveness.🚀 This method is ideal for encapsulation and drug delivery applications.💊 For more details, explore our application note or contact us📲: Application note: https://lnkd.in/d-dh3sTN Contact Us: https://lnkd.in/gCbGDDh #Microbeads #DrugDelivery #Biotech

The start of the collaboration with Nicolas Védrenne from INSERM U1248 Pharmacology & Transplantation, Faculty of Medicine, University of Limoges to study the toxicity mechanism on Organ-on-chip (OOAC) models. 🧪🔬 Using the Dual Omi™ system (https://lnkd.in/dAEBcZk4), Dr. Védrenne and his team are studying how tacrolimus and its metabolites impact liver-kidney interactions. 🧬 Tacrolimus is primarily metabolized in the liver, yet its toxicity predominantly affects the kidneys. Studying its metabolic pathways in integrated liver-kidney models is essential for elucidating these adverse effects. 🫀 Stay tuned for the progression of the project! 🚀👀 Thanks to Dr. Védrenne and his team: Nicolas Védrenne Jean sėbastien Bernard Isy Petit #liveronachip #toxicity #OOAC #microfluidics #coculture

NEW WEBINAR: The Importance of Flow in Organ-on-a-Chip Join us for an exclusive webinar showcasing the importance of flow in the organ on a chip system, featuring the gut-on-a-chip model by Elise Delannoy from Institute Pasteur Lille! As Organ-on-a-Chip (OOC) and Microphysiological Systems (MPS) evolve, mastering flow control is critical for long-term experiments. This webinar will dive into the role of perfusion, shear stress, and design considerations in OOC models. 🎤 Featured Speaker: Dr. Delannoy will share insights on her Bioengineered Human Gut-on-Chip Model. 📅 Date: 6th March 2025 ⏰ Time: 10 AM CET (Paris time): https://lnkd.in/esNjmNiy 4 PM CET (Paris time): https://lnkd.in/ePhKRpAm 🔍 What You’ll Learn: ✔️ Current trends & challenges in Organ-on-a-Chip model design ✔️ Standards in OOC flow control & shear stress estimation ✔️ Microfluidic setups to optimize OOC experiments ✔️ Case Study: Gut-on-Chip model to Study Host-Microbiome Interactions from Dr. Delannoy ✔️ Fluigent solutions: OOC case study review & Omi™ system introduction Whether you're an expert or just getting started with OOC, this webinar will provide valuable insights and practical guidance to enhance your research! 📢 Don’t miss out – secure your spot today! #OrganOnAChip #GutOnAChip #Microfluidics #BiomedicalResearch #Perfusion

🔬 Complete your microfluidic setup with smart control & automation! 🔬   Discover Fluigent’s Microfluidic Valves—2-SWITCH, M-SWITCH, and L-SWITCH—designed for efficient fluidic path management and real-time control.   With Fluigent software solutions, automate valve actuation for precise, time-based protocols.   Ideal for applications such as: ✅ Sequential injections ✅ Sample distribution & injection ✅ Fluid recirculation   Enhance your microfluidic workflows today! 📩 Have questions? Click here to discuss your needs: https://lnkd.in/gCbGDDh   🎥 Discover how it works! Watch the demo now: https://lnkd.in/eXrjbZ5J #Valves #Automation #Microfluidics #Fluigent

🔬 Meet us today at CSEM’s Next-Gen Organ-on-Chips & Organoids Workshop!   📅 On February 13th and 14th, Fluigent, in association with microfluidic ChipShop GmbH, is participating in the CSEM Organ-on-a-Chip Workshop, bringing together key players in pharma, biotech, and organ-on-a-chip research. 👀 If you are attending, come see Omi™—our automated Organ-on-a-Chip platform—in action! Omi™ is designed to simplify your microfluidic setup and automate your experiments. 💡 Our Application Engineer, Anel R., will be available to discuss how Omi™ can help advance your research and address microfluidic challenges in drug development and disease modeling. ➡️ Learn more about Omi™ and how it can streamline your research by visiting our product page here: https://lnkd.in/dAEBcZk4 #MPS #organonachip #OOC #microfluidics #labautomation 🚀

We are thrilled to see our Aria system, dedicated to spatial omics, being used to automate iterative immunolabeling—enabling seamless imaging with up to 30 colors! 🔬🚀✨ #Omics #immunolabeling

Advancing Cardiac Research with Precision Microfluidics ❓ How does the developing heart respond to mechanical load? Researchers at Dalhousie University’s Cardiac, Autoregulation & Arrhythmias Laboratory, led by Dr. Alex Quinn, explored this using a controlled microinjection approach with a microcannula in zebrafish larvae.* With Fluigent’s FlowEZ™ pressure controller, Flow Unit sensor, and OxyGEN software, they achieved precise atrial dilation, revealing that early-stage adaptation relies on mechano-mechanical coupling, unlike in adults. 🗨️ “The FlowEZ pressure controller made setting up a custom microfluidics system for our specific needs quick and simple. It’s ease of use and user-friendly implementation have allowed for precise and reliable control of cardiac mechanical load in both larval and adult zebrafish.” — Dr. Alex Quinn, Dalhousie University We are pleased to collaborate with and support the lab in advancing cardiac research. 📖 Learn how Fluigent enables precise mechanobiology studies: https://lnkd.in/eWa6qpZY Jonathan Baillie, Alex Gendernalik, Deborah M. Garrity, David Bark Jr., Alexander Quinn; The in Vivo Study of Cardiac Mechano-Electric and Mechano-Mechanical Coupling during Heart Development in Zebrafish. Front. Physiol. 2023, 14, 1086050 #CardiacResearch #Microfluidics #Fluigent #Microcannula #ZebrafishModel #BiomedicalEngineering #FlowControl

Why Does Shear Stress Matter in Organ-on-a-Chip Design? Are you designing or selecting an organ-on-a-chip device? Shear stress is a critical parameter for modeling endothelial and epithelial barriers. Underestimating it can lead to unreliable results or even failed experiments. Key Considerations for Your Workflow: 👉 How do you estimate shear stress? Are you accounting for channel geometry and flow dynamics? 👉 Does your setup allow real-time shear stress control to mimic physiological conditions? Solutions for Precision & Ease: 1️. Free Shear Stress Calculator Quickly estimate shear stress for your design using our user-friendly tool. 👉 Calculate Now : https://bit.ly/413BaF5 🎥 Watch How It Works: Shear Stress Tutorial Video : https://bit.ly/42KhXcR 2. Automated Control with Omi Why calculate manually when you can automate? By inputting your channel geometry and the dynamic viscosity of your cell culture medium, Omi directly operates at your desired shear stress levels. This eliminates the need for manual calculations, ensuring precise and consistent shear stress conditions for your experiments. Why Partner with Fluigent? We’re committed to advancing organ-on-a-chip research with tools that simplify complexity. Whether you’re prototyping a custom chip or using commercial systems, let us help you achieve reproducible and physiologically relevant results. #OrganOnAChip, #Microfluidics, #Innovation, #BiomedicalEngineering

🔬 Explore our microfluidic solutions: pressure and vacuum control, flow rate control, microfluidic valve automation, and software control. Select and combine the modules you need from our range of LineUp™ products. In this video, you’ll see how our LineUp™ Series can streamline your workflow. Our devices have become the gold standard for microfluidic flow control over the years due to: 🔹Flexibility: Combine and stack up to 8 modules as your workflow grows. Our solution is fully modular. 🔹Ease of Use: Straightforward setup thanks to the local control features and our user-friendly OxyGEN software. 🔹Compactness: Uses minimal bench space. 🔹High performance: High precision pressure and flow rate control to meet the demands of microfluidic experiments. Don't miss this chance to see an overview of LineUp™ Series. 📽️ Click the link below to watch now! https://bit.ly/4jKQOwI 🔗 Discover our Flow EZ: https://bit.ly/4jNiWiL 🔗 Discover our LineUp™ Product Series: https://bit.ly/4jJgKIL #microfluidics #pressurecontroller #flowcontrol #flowEZ #Fluigent