Prof. Lukas Bubendorf von der Pathologie des USB hat gemeinsam mit den Kolleginnen und Kollegen vom D-BSSE eindrückliche Resultate erzielt.
A recent study in Nature Physics on the early stages of bladder cancer shows the importance of mechanical changes in tumour tissue during growth. The study was led by the Computational Biology group of Dagmar Iber, ETH Zürich in collaboration with Lukas Bubendorf’s pathology lab at the University Hospital Basel and the D-BSSE group of Biophysics. 🎥 In this video, the team presents the findings of their research on the onset of epithelial bladder cancer. The researchers’ motivation was to understand what governs the direction in which bladder tumour grows. This growth direction can play a key role in whether it proves malignant or benign. In turn, this also determines the course of treatment and the patient’s chances of survival. Combining 3D-microscopy with computational modelling, the researchers found that the tumour type, its structure and the biomechanical properties of the bladder tissue influence the growth direction of bladder tumours, a critical factor in determining the aggressiveness of bladder cancer. The team calls for a stronger focus on tissue mechanics in future cancer research, suggesting that this approach could lead to more targeted and effective therapies for patients. Thanks to all collaborators: Roman Vetter, Kevin Yamauchi, Yifan Wang, Steve Runser, Nico Strohmeyer, Florian Meer, Marie Hussherr, Gieri Camenisch, Helge Seifert, Cyrill Rentsch, Clémentine Le Magnen, Daniel J. Müller, Lukas Bubendorf, Dagmar Iber Find full news article > https://u.ethz.ch/D5Bw3 View full-length video > https://lnkd.in/ei4-qK-t #Biomechanics #CancerResearch #BladderCancer #PersonalizedMedicine #MedicalInnovation #NaturePhysics #3DMicroscopy #ComputationalBiology #TumorResearch #HealthcareInnovation