Danish Cancer Institute

🌟 Introducing the Redox Biology Group 🌟 The groups main interest is to study the role redox modifications (mainly S-nitrosylation) in human pathophysiology with special emphasis in the mechanisms underlying cancer onset and progression. Scroll through the pictures below to learn more about the REB group and their research work 👇 Giuseppe Filomeni Chiara Pecorari Letizia Incampo Mojca Bratina Salvatore Rizza

📢 New research introduce 3D skin models for studying serious skin conditions, such as melanoma. With contributions from Daniela De Zio, team leader of the Melanoma Research Group at the Danish Cancer Institute, a team of scientists at Syddansk Universitet - University of Southern Denmark has developed 3D human skin models that mimic the structure and behavior of real skin, providing an effective and ethical alternative to animal testing for studying diseases like melanoma. Using bioimaging and RNA sequencing, researchers demonstrated that these skin models closely resemble human skin’s architecture and gene activity, particularly in full-thickness models, which even replicate the skin’s basement membrane and cell interactions. When melanoma cells were added, the models maintained their skin-like properties, proving they can serve as reliable tools for cancer research. The study was recently published in Acta Biomaterialia.

🌟 Denmark is a world leader in epidemiological research. Thanks to extensive national health registries, comprehensive biobank samples, and large population-based cohorts, our researchers have insights that few other countries can match.   These unique research tools allow scientists at the Danish Cancer Institute to carry out some of the most advanced and extensive cancer studies in the world.   In this video, PhD Fie Andersen shares how she uses data-driven research to identify healthcare inequalities, with a specific focus on gender disparities in cancer.  

🎉 Senior scientist Daniela De Zio and the Danish Cancer Institute have secured 2.4 million kroner from Kræftens Bekæmpelse (Danish Cancer Society)’s Knæk Cancer programme to fund research into whether the protein AMBRA1 can predict how cancers will respond to treatment. Daniela De Zio, team leader in the Melanoma Research Group, says: “Melanoma, the most lethal form of skin cancer, poses a major challenge with its ability to spread rapidly if not treated early. Advances in targeted therapies and immunotherapies have changed the game, helping some patients fight back. Yet, many still face resistance to these treatments. Our research is spotlighting a gene, AMBRA1, which may predict resistance to these treatments, potentially guiding smarter, personalised therapies for melanoma patients.” The study will be done in collaboration with OUH Odense Universitetshospital – Svendborg Sygehus Congratulations 👏🎉

📰 NEWS: New research offers reassuring news for women receiving fertility treatment. Researchers from the Danish Cancer Institute have found that there is no connection between the most commonly used fertility hormones and ovarian cancer. This large-scale study, which examined over 150,000 women with fertility issues, provides the most precise evidence to date. The research assessed the five most frequently used hormones in fertility therapy and found no increase in the risk of ovarian cancer with any of them. In this video, senior scientist Allan Jensen, who led the study, explains that while the hormone progesterone showed a slight increase in risk for a rare ovarian cancer subtype, the absolute risk of ovarian cancer remains very small.

📢 We’re hiring! Are you a skilled computational scientist ready to join a cutting-edge facility at the forefront of cancer research? 🚀 This is a unique opportunity to shape and support our pioneering new optical pooled screening infrastructure. In this role, you’ll be instrumental in establishing and managing the computational workflows that power our open-access infrastructure, enabling researchers to unlock new insights into the genetic drivers of complex biological phenomena. Professor Jakob Nilsson will be heading the Optical Pooled Screening Facility. In this video, he explains more about the facility and how it will provide researchers from across Denmark with access to state-of-the-art technology. The application deadline is 17 January 2025. Please find the link to the application site in the comments below.

New research will explore how depression influences mortality rates among cancer patients, investigating whether individuals with depression face a higher risk of cancer-related death compared to others. Camilla Keller from the Cancer Survivorship Group at the Danish Cancer Institute will lead the study. 💬 “This grant allows us to explore one of the most vulnerable patient groups: cancer patients with depression. We will examine whether depression increases the risk of cancer mortality and unnatural death across the 25 most common cancers and whether depression’s impact on mortality is stronger in cancer survivors compared to the general population with depression but no cancer. Our goal is to identify high-risk groups in need of extra care,” Camilla Keller explains. Research Group Leader Susanne Dalton hopes the study will pave the way for more targeted support and prevention strategies for the most vulnerable. 💬 “We are very grateful to receive funding for this project. We know from previous studies that co-existing diseases at the time of cancer diagnosis may impact survival — and this includes depression. Now, across different cancer types, we aim to uncover the impact of depression on survival rates. Just as cancer requires optimal treatment, so does depression, and there may be a need for coordinated care across medical specialties to ensure that cancer patients with depression benefit fully from both cancer and depression treatment,” Susanne Oksbjerg Dalton explains. The research project, ‘Mortality after Treatment for Depression in Cancer Patients’, is funded by Independent Research Fund Denmark.

📢 Research by Danish Cancer Institute scientists has led to the The Danish Parliament - Folketinget allocating funds specifically for research into the side effects of hormonal contraception. The news comes after a newly published article linked the use of the Levonorgestrel-Releasing Intrauterine Device (LNG-IUD) to breast cancer in women. We are proud of the part that research from the DCI has played in bringing attention to an area that has long been underexplored, and we look forward to contributing to a more profound understanding of how hormonal contraception affects women’s health. The research was published in JAMA in October - link in the comments below

𝙉𝙚𝙬𝙨: 𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙛𝙧𝙤𝙢 𝙩𝙝𝙚 Danish Cancer Institute 𝙖𝙧𝙚 𝙨𝙚𝙩 𝙩𝙤 𝙞𝙣𝙫𝙚𝙨𝙩𝙞𝙜𝙖𝙩𝙚 𝙝𝙤𝙬 𝙪𝙡𝙩𝙧𝙖𝙛𝙞𝙣𝙚 𝙥𝙖𝙧𝙩𝙞𝙘𝙡𝙚𝙨 𝙞𝙢𝙥𝙖𝙘𝙩 𝙩𝙝𝙚 𝙝𝙚𝙖𝙡𝙩𝙝 𝙤𝙛 𝙥𝙚𝙤𝙥𝙡𝙚 𝙡𝙞𝙫𝙞𝙣𝙜 𝙣𝙚𝙖𝙧 𝙖𝙞𝙧𝙥𝙤𝙧𝙩𝙨. Recent studies have detected high levels of ultrafine particles around Copenhagen Airports A/S, yet the full extent of their effects on residents' health remains unclear. In response, Environment Minister Magnus Heunicke has called for an investigation into the health implications of these particles at the airport. Professor Mette Sørensen, who will lead the research, explains: 💬 "Ultrafine particles from airports are potentially harmful to health, but our understanding in this area is still limited. Therefore, at the Danish Cancer Institute and the Kræftens Bekæmpelse (Danish Cancer Society), we are pleased to launch a study that will examine whether residents near Copenhagen Airport face an increased risk of illness and mortality due to their exposure to ultrafine particles. This research is vital for the thousands of people living in the airport’s vicinity who are exposed to these particles daily." The research is funded by the Danish Ministry of Environment and Gender Equality and is expected to be completed within two years.

📢 We’re hiring! The Danish Cancer Institute is offering a 2-year Postdoctoral position in the Work, Environment, and Cancer research group. Applicants must hold an MSc in Public Health, Health Informatics, Human Biology, or a related field, as well as a PhD with a focus on epidemiology. 📊 The successful candidate will work on the WorkSOUND research project, which aims to investigate whether exposure to occupational noise, alone or in combination with other stressors, increases the risk of various diseases. 💡 For questions regarding the project, please contact Group Leader and Professor Mette Sørensen 📧 mettes@cancer.dk or 📞 +45 3525 7626. The application deadline is November 17, 2024. Apply via the link below. https://shorturl.at/C9tCt #cancerresearch #epidemiology #postdoc #vacancy