Fida Biosystems

Explore a brand new publication from The Astbury Centre for Structural Molecular Biology; University of Leeds ➡️ Entitled "Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug" , in which Flow-Induced Dispersion Analysis (FIDA) was employed to investigate the interaction between canagliflozin and amyloid-forming proteins. 📙 FIDA enabled the researcher team to monitor changes in the hydrodynamic radius of these proteins in real-time, providing critical insights into how canagliflozin influences amyloid formation kinetics and polymorphism. This application of FIDA underscores its utility in characterizing complex biomolecular interactions under physiologically relevant conditions, thereby advancing our understanding of therapeutic mechanisms at the molecular level. Read more here: https://lnkd.in/dGYmxAj9 🗓️And remember to sign up for a one day meeting about Protein Activity Allostery & Assembly at Leeds University https://lnkd.in/dd5kDvWd

Last few spaces remaining! From mechanistic structural biology, analysis of membrane proteins in SMALPS to fibrils and condensate research - possibly one of the most varied and interesting protein science meetings there is!

Many of linkedin members are here to advance their career, network, get inspired - but it's not the same as in real life! That's why on May 27th we will meet in Paris for yet another of our User Group Meetings. What can you expect? 🧠 Knowledge dissemination sessions: Learn from the expertise of worldwide renown experts 💪 Training workshops: Skill up and make the most out of your tools 💬 Discussions: Get advice and inspiration from other FIDA users and our in-house specialists Where to sign up? https://lnkd.in/d3V6-bwv Is it for free? Fidabio sponsors participation if you sign up asap! Can I join if I am not a user? Yes - as long as you have a curious scientific mind 🇫🇷 See you in Paris!

If you're a curious type you're probably wondering how does in-solution binding kinetics work work? FIDA technology measures in-solution kinetics by tracking changes in the hydrodynamic radius of a target molecule as it interacts with a binding partner. As binding occurs, the complex size changes, allowing precise determination of affinity (Kd) and kinetic rates (Kon/Koff). Because this approach takes place entirely in solution, it avoids surface effects and preserves the native behavior of molecules, making it well-suited for studying interactions in complex biological samples. Watch an on-demand webinar with Dr.Henrik Jensen explains it all in detail:

How many days would you save if you eliminated the need for surface immobilization in kinetics studies?🧐 Just think: no steric hindrance, no surface optimisation issues, no non-specific interactions. You're not even dreaming. 🟠 FIDA allows you to measure in-solution binding kinetics. It avoids surface optimisation issues, steric hindrance, nonspecific interactions, and conformational changes associated with surface-based methods. Operating under physiologically relevant conditions, FIDA provides unparalleled flexibility and reliability for analyzing complex biomolecular interactions, including those with long off-rates. We could continue listing benefits, but we'd rather you see it by yourself: https://lnkd.in/d6HKhSbA

There is nothing more rewarding than training new Fida Instrument owners! This time our FAS Einar visited Tim Sharpe at the University of Basel 🇨🇭 for an onboarding training. It was a pleasure - Tim Sharpe, Alexander Rau, Tobias Mühlethaler.

💡 Opinion: Working with membrane proteins is easier and more efficient if you can skip the purification step - don't you agree? 👉 How? Conventional techniques such as SPR, FSEC, or other surface-based and bulk approaches require purification & often fail with hydrophobic or unstable membrane proteins. Meanwhile, FIDA technology enables in-solution characterization of membrane proteins, even in detergents, liposomes, or nanodiscs. With minimal sample consumption and multiple structural and functional readouts from a single assay, FIDA provides you with a reliable and efficient way to study membrane protein interactions while preserving native-like conditions and functionality. With minimal sample consumption and multiple structural and functional readouts from a single assay, FIDA provides researchers with a reliable and efficient way to study membrane protein interactions while preserving native-like conditions and functionality. 🙌 Easy - that's FIDA. Check out our membrane protein literature: https://lnkd.in/dSbcnruA

We're always happy to support young scientists! 🛫 By the way, do you remember our young scientist travel grant? https://lnkd.in/em-2C3Q2

Celebrating Science, Support, and.....Fun! ✨ Our brand-new Field Application Scientist, Einar Halldórsson, recently visited Institut Curie and Museum national d'Histoire naturelle Naturelle in #Paris to train even more FIDA users. At Fidabio, we believe that innovative technology is only as powerful as the people using it. That’s why we put such a strong emphasis on training and user support—helping researchers get the most out of their data and making sure every FIDA measurement counts. As a company born from a love of science, our mission is to not only advance technology but also empower scientists with the knowledge and confidence to push their research further. We’ll keep traveling, training, and supporting our community—because great science happens when the right tools and expertise come together. And of course, Einar also got the chance to visit the Paris zoo 🦩

🫠 Let's be frank, studying biomolecular interactions can come with many challenges, especially when surface-based methods introduce steric hindrance, nonspecific interactions, and regeneration issues. 🟠 FIDA offers a different approach—measuring in-solution binding kinetics under physiologically relevant conditions. This means researchers can capture complex interactions, including those with long off-rates, without the limitations of surface attachment. A step forward in understanding molecular behavior with precision - and towards faster and less burdensome workflows 🍹 Visit https://lnkd.in/d6HKhSbA