Recently, the internet of thing (IOT) has been growing rapidly in many fields including in the biomedical vital sign monitoring of a human. Heart rate and SPO2 are vital sign parameters for human life. Those parameters needed to be observed for patients in an emergency situation. In patient care at hospitals, doctors need to monitor the patients' heart rate and SPO2 parameters continuously. Therefore, the objective of this study was to develop the heart rate and SPO2 parameters based on IOT technology. The heart rate and SPO2 parameters were detected using a finger sensor and an oximeter sensor, respectively. The digital data from those sensors, further, was processed using ESP8266 microcontroller. By using a built-in Wi-Fi module in ESP8266, the vital sign was sent to the user wirelessly to handphone or central monitor using Think Speak application, remotely. In this experiment, the sensors were placed on the finger while the patient was in the standing, lying or sitting position. In the same position, the parameters were acquired for ten times. Some analyses were conducted to find the accuracy of the measurement. The results showed that the uncertainty were 0.26 and 0.04 for heart rate and SPO2, respectively. Based on the medical standard calibration (<3%), those parameters are feasible to be used in the medical system measurement. The T-test analysis statistics for one independent sample was performed to obtain a significant difference among the data. The p-values were 0.118 and 0.000 for heart rate and SpO2, respectively. Finally, this study suggested that the IOT system was able to monitor the parameters effectively.