Schüffner's dots

Schüffner's dots refers to a hematological finding that is associated with malaria,^[1] exclusively found in infections caused by Plasmodium ovale or Plasmodium vivax.^[2]

Plasmodium vivax induces morphologic alterations in infected host erythrocytes that are visible by light microscopy in Romanowsky-stained blood smears as multiple brick-red dots. These morphologic changes, referred to as Schüffner's dots, are important in the identification of this species of malarial parasite and have been associated by electron microscopy with caveolavesicle complexes along the erythrocyte plasmalemma.^[3]

They are named for Wilhelm Schüffner, who described them in 1904.^[4]

References

^ "Royal Perth Hospital - Malaria Diagnosis".
^ "Microscopy of Plasmodium species".
^ Udagama, P. V.; Atkinson, C. T.; Peiris, J. S.; David, P. H.; Mendis, K. N.; Aikawa, M. (1988). "Immunoelectron microscopy of Schüffner's dots in Plasmodium vivax-infected human erythrocytes". The American Journal of Pathology. 131 (1): 48–52. PMC 1880566. PMID 3281470.
^ "Schuffner's+dots - Definition from Merriam-Webster's Medical Dictionary". Archived from the original on 2012-09-22.

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[urlRoyal_Perth_Hospital_-_Malaria_Diagnosis-1] "Royal Perth Hospital - Malaria Diagnosis".

[urlMicroscopy_of_Plasmodium_species-2] "Microscopy of Plasmodium species".

[3] Udagama, P. V.; Atkinson, C. T.; Peiris, J. S.; David, P. H.; Mendis, K. N.; Aikawa, M. (1988). "Immunoelectron microscopy of Schüffner's dots in Plasmodium vivax-infected human erythrocytes". The American Journal of Pathology. 131 (1): 48–52. PMC 1880566. PMID 3281470.

[urlSchuffners+dots_-_Definition_from_Merriam-Websters_Medical_Dictionary-4] "Schuffner's+dots - Definition from Merriam-Webster's Medical Dictionary". Archived from the original on 2012-09-22.

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v t e Blood tests for infectious disease
Bacterial infection	syphilis Venereal Disease Research Laboratory test rapid plasma reagin Wassermann test Fluorescent treponemal antibody absorption test Abelin reaction Rickettsia Weil–Felix test Helicobacter HelicoCARE direct Streptococcus Anti-streptolysin O
Viral infection	HIV testing Branched DNA assay mChip Epstein–Barr virus Heterophile antibody test Dengue fever NS1 antigen test measles Warthin–Finkeldey cell Inclusion bodies Downie bodies B type inclusion Orthopoxvirus inclusion bodies rabies Negri bodies Cowdry bodies yellow fever Councilman body Tzanck test
Protozoan infection	toxoplasmosis Sabin–Feldman dye test malaria Diagnosis of malaria Schüffner's dots
Bloodstream infections	Blood culture Viremia Fungemia Parasitemia Algaemia
General	C-reactive protein Procalcitonin