RX2 Sports & Health Center

What a kickoff of the new year! 🍾 I am very excited to be speaking at the #Probiota2025, about the athletic gut microbiota, the #Gut-#Muscle #Axis and implications in exercise performance. I will lead you into the magical world of the AI applied to the gut microbiota analysis, the idea of #digital #twins for athletes and the possibility to optimize performance and prevent injuries working on microbial composition and functions... How? Through a #personalized #nutritional intervention. See you there? ✨ 💜 🥇 Minutia.AI

#Muscle #Immunity and #Gut #Microbiota: a new frontier in #Precision #Medicine in #Sports The gut microbiota plays a key role in the maturation and differentiation of immune cells, shaping and regulating the responses to immune-mediated diseases, not excluding muscle immunity. The immune system is equipped with innate immune sensors, Toll-like receptors (TLR), expressed by macrophages, lymphocytes, and dendritic cells (DC) and NOD-like receptors (NLR). Gut microbiota interacts with immune cells and intestinal epithelial cells by #TLRs and #NLRs. While TLRs stimulate innate intestinal immunity by interacting with a broad spectrum of microbial-associated molecular models (MAMP), such as LPS, flagellin, muramic acid, peptidoglycan residues etc., NLRs perceive specific microbial molecules and direct the assembly of #inflammasomes. Following the detection of the appropriate signal, they create a multiprotein complex that drives the activation of pro-inflammatory cytokines (IL-1, IL-6, IL-12, IL-18 and IL-23), which regulate the balance of Th17/Treg cells towards Th17 cells. In healthy muscles, #Treg #cells regulate immune response and influence muscular differentiation and repair, coordinating the interactions between immune and muscle cells and providing immune memory to muscle (https://lnkd.in/dK8tzUp3). #Muscle #injury trigger an inflammatory response with a rapid increase of intramuscular leukocytes (more than 100-fold). Resident macrophages facilitate a massive neutrophil invasion followed by the activation of succeeding immune cell populations. The protective role of #butyrate in gut barrier function is crucial as reported by a recent study (https://lnkd.in/dfCbZ2hX) in which it was shown the barrier protection was achieved by inhibiting endotoxin translocation, reducing inflammation, and preventing skeletal muscle atrophy. Butyrate regulates macrophage activities by inhibiting LPS-induced M1 polarization and enhancing IL-4-induced M2polarization. M2 macrophages promote the regeneration of skeletal muscle tissue through the secretion of anti-inflammatory cytokines and inducing Treg recruitment to the targeted area, triggering the proliferation and differentiation of satellite cells (#myogenesis). The #butyrate-#macrophage-#skeletal #muscle #axis contributes to muscle repair and homeostasis offering interesting insight in the exploration of the gut-muscle axis as predictive tool for muscle injuries. The gut microbiota is a transducer of nutrient signals to the host, able to regulate immune response, inflammation, and mitochondrial biogenesis. A fine regulation of its composition and functions through #personalized #dietary #interventions could result in effective therapeutic strategies to work on muscle injuries in sports and in clinics. What are we waiting for? ⌛ “Never put off for tomorrow, what you can do today.” Aaron Burr ✨   LINK: https://lnkd.in/dZCWvKQz www.minutia.ai

#Musculoskeletal #injuries in #sports: promises and hopes from the #gut #microbiota 😊 #Sports #injuries are among the root causes of poor performance and bad physical progression in #athletes, negatively impacting the affinity to training with consequences on the psychological well-being. Mechanical overuse of musculoskeletal structures (bone, cartilage, skeletal muscle, tendon), especially in endurance sports, #pain (alteration of nociceptive cells) and #chronic #systemic #inflammation, contribute to injuries as well. ✨ Why does the #gut #health matter? Causes of sports injuries are multifactorial but undoubtedly a chronic inflammatory state may exacerbate musculoskeletal loss of functions. The microbiota plays an essential role in developing and preserving the intestinal barrier, immune and metabolic homeostasis, while impairing systemic inflammation or a leaky gut syndrome. In addition, promoting the intestinal absorption of #antioxidants and #vitamin release, the gut microbiota elicits an anti-oxidative stress effect. Specifically, bacterial species such as Lactobacillus plantarum, L. gasseri, L. fermentum, Lactococcus lactis, Streptococcus thermophilus, and Bifidobacterium genera contribute to a high antioxidant activity. ✨ How is gut microbiota related to injuries? #Leaky #gut #syndrome appears when selective intestinal permeability is impaired, and a leakage of positive and negative bacteria, metabolites, and toxins cross the barrier and enter the bloodstream, leading to systemic #endotoxemia. Consequently, the immune response alters nociception and pain sensitivity, promoting musculoskeletal soreness, bad recovery, local inflammation and autoimmunity. Gut microbiota protects the intestinal barrier by fostering interactions of commensal bacteria with the intestinal mucosa and mucus. In optimal conditions our gut barrier selectively accepts nutrients, metabolites, and other bioactive molecules to go to the bloodstream, preventing translocation of potential pathogens, microbial antigens, toxins, and other harmful molecules. Interventions aimed at improving the microbial ecosystem in the gut could rapidly reduce either pain or inflammatory conditions behind musculoskeletal injury. ✨ What to do in practice? Testing the gut microbiota in relation to poor performance, high inflammatory state, recurring injuries and/or autoimmune disease could help in detecting the dysbiosis behind those symptoms and redact #personalized #nutritional #interventions (tailored diets + pre- and probiotic intake) to address the microbial composition toward a healthier state, as a novel therapeutic approach to work on systemic inflammation. Believe it or not, the future is there! 🚀 #Precision #Medicine and #Precision #Nutrition in #Sports LINK: https://lnkd.in/d3eHrivN www.minutia.ai

Análisis que ofrecemos desde RX2 a cualquier golfista interesado en mejorar su rendimiento y prevenir lesiones de manera objetiva y precisa. Simi Reality Motion Systems biomech

Este jueves 12 de diciembre tendrá lugar un evento que considero es realmente interesante si te dedicas de alguna manera al alto rendimiento en el deporte. Profesionales de altísimo nivel hablarán sobre la importancia de un enfoque integral y un equipo multidisciplinar para la prevención de lesiones y la mejora del rendimiento deportivo. Aún estás a tiempo de registrarte, así que no lo dudes! RX2 Sports & Health Center NESA WORLD #biomecánica #prevención #microbioma #neuromodulaciónnoinvasiva #nutricióndeprecisión #terapiasregenerativas #binestaremocional

🆕📚WORKSHOP: “Abordaje integral de las lesiones de LCA” 🗓️18 y 19 de enero de 2025 ➡️Os presentamos este nuevo curso que discutirá los desafíos, cada vez mayores, relacionados con la prevención y la rehabilitación tras la cirugía del LCA, así como el uso de la biomecánica para la mejora del proceso rehabilitador, siendo una herramienta clave para la obtención de datos precisos y objetivos para la toma de decisiones en el proceso de “Return To Play” 👨⚕️ Forman parte de este curso nuestros profesionales expertos: Andrea Astrella Silvio Villascusa Marin, MD Luis Cerezal Pesquera y Pedro Moreno. ¿Cómo apuntarte? 📩 info@rx2center.com ☎️ 913 89 41 34 📲 654 88 64 85 📍Paseo del Club Deportivo 4, Pozuelo de Alarcón, Madrid #rx2 #medicinadeldeporte #fisioterapia #ligamentocruzado #lesion #biomecanica #LCA #curso

Una invitación de RX2 Sports & Health Center para un día de innovación científica y aprendizaje en el ámbito deportivo. El 12 de diciembre de 2024, en Pozuelo de Alarcón, Madrid, se llevará a cabo un evento académico clave sobre la importancia de un enfoque integral en el deportista de alto rendimiento. Se abordarán temas fundamentales como la optimización del sistema nervioso autónomo, la biomecánica avanzada, el microbioma intestinal y su influencia en el rendimiento, así como el uso de tratamientos ortobiológicos para deportistas de élite. Este encuentro reunirá a expertos que compartirán conocimientos científicos innovadores, ofreciendo nuevas perspectivas sobre las investigaciones y metodologías que optimizan la salud y el rendimiento físico de los atletas. #NesaWorld #Neuromodulación #DeporteDeAltoRendimiento #CienciaDelDeporte #SaludIntegral #Biomecánica #Innovación #RendimientoFísico #MedicinaDeportiva #AvancesCientíficos

During this week, some of the European School of Sports students have been at the RX2 Sports & Health Center for their effort tests 💪 🙏 Thank you very much! #europeanschoolofsports #ESS #carreradual #dualcarrer #sports #business #sportsbiz #education #degree #masters

👤 Eduardo Lechuga de Boer, fisioterapeuta especializado en medicina manual y osteopatía, y especialista en Neuromodulación No Invasiva NESA WORLD será uno de los ponentes del evento del 12 de diciembre en 📍RX2. Te recordamos que las plazas son limitadas así que no lo dudes más e inscríbete: 913 894 134 / 654 886 485

The #Brain-#Gut-#Muscle #Axis: a new frontier in exercise physiology? 💫 The concept of the brain–gut–muscle axis is gaining attention as a fundamental crossroad for energy homeostasis, exercise performance and overall health. As Marcus Aurelius said: "Reject your sense of injury, and the injury itself disappears”, the mind can be in control of the body, in health or disease, in healing or exercising. ✨ Communications between the gut microbiota and the nervous system (#gut– #brain #axis) involves the enteric nervous system, vagus nerve, the immune and endocrine systems. The enteric nervous system, made by enteroendocrine cells, release hormones that cross the blood brain barrier (BBB), reaching the brain cells. The vagus nerve, intricately connected to enteroendocrine cells, represents a central link in the gut-brain crosstalk. Immune-signaling mediators such as cytokines, chemokines, and microbial-associated molecular patterns (MAMPs) play a crucial role in the communication between the gut microbiota and the brain. Through these signaling pathways, the gut microbiota influences #immune #responses and #neuroinflammation, while the brain acts regulating motility, mucus secretion, barrier integrity, and visceral sensitivity. One example? Let’s focus on #lactate and its role as signalling molecule... 🚦 Far beyond being a waste or fatigue substance, lactate is a stress-related signaling molecule that plays key roles in health and disease. Biomarker, used in exercise and sport physiology, lactate positively correlates with exercise intensity (stress level). Some of its pleiotropic functions include: 1. regulation of energy production (Cori’s cycle, also extended to the gut with SCFA release, crossroad between glycolysis and oxidative metabolism, changes in substrate utilization); 2. cross-talking between tissues via monocarboxylate transporter isoforms (MCTs); 3. epigenetic role (lactylation) Lactate clearance, production, and transportation are not only regulated by exercise intensity, type of metabolism and glucose availability, but also by genetic variations in lactate-related genes (MCTs) and gut microbiota. #Veillonella #atypica (next generation probiotic developed by FitBiomics), #Eubacterium #hallii, #Anaerobutyricum #hallii, #Anaerostipes are examples of bacteria that metabolize lactate into SCFAs supporting energetic need in endurance and promoting SCFA delivery to the brain. While #exercise boosts the flux of SCFAs and lactate via an increased expression of MCTs, in neuropathological diseases, tissues are not efficiently clearing this metabolite, resulting in an allostatic overload and consequent symptoms. Regular and moderate exercise, reshaping gut microbiota diversity and metabolic activity, elicits positive impacts on muscle, brain and overall well-being. How far are we from gut microbiota-based, precision exercise interventions? ⌛ 🚴 📄 LINK: https://lnkd.in/dxhQZKqJ www.minutia.ai