CellQuest

Voici la synthèse de l'ARM pour le secteur de la thérapie cellulaire et génique d’avril 2024. Cela fait plaisir de voir les #CARTcells désormais positionnés comme traitement de deuxième intention. https://lnkd.in/d_pPjmQj

Amazing & well deserved ! Making these therapies affordable & accessible to the widest number is the (our!) next big challenge.

Automated CAR-T Manufacturing Moves toward the Marketplace Producing CAR-T cells at scale is one of the challenges to manufacturing these life-changing therapies. CellQuest believes their mini-factory can help contract manufacturers reduce costs while scaling-out CAR-T therapies.

Automated CAR-T Manufacturing Moves toward the Marketplace A French company is seeking to solve one of the biggest challenges in the emerging cell therapy industry by commercializing an automated system for manufacturing CAR-T at scale. CellQuest, who has recently shared their technology with early-access users, believes their mini-factory can help contract manufacturers reduce costs while scaling-out CAR-T therapies. Current CAR-T therapies typically cost from $500,000 to £1,000,000 to treat a single patient, with the production of these patient-tailored medicines, making it a significant factor. CellQuest claims they’ve developed an automated system that can manufacture 6,000 CAR-T doses a year in less than 300 square feet of space. The company says this is 30 times the throughput of typical production today, and at a much lower cost. According to Yon and CellQuest CEO, Guillaume Wallart, CellQuest’s technology consists of a unit about the size of a fridge, which can take up to 15 trays that work like mini production units. Each tray contains a single patient dose and has a pouch with compartments where all critical CAR-T production steps, including cell sorting, selection, transduction, and expansion can take place. The entire process is automated and delivered via a metal structure with clamps that can, for example, open and close compartments within the pouch or agitate the cells during culture. The pouch is connected, sterilely, to four cartridges containing pre-filled and pre-dosed ingredients for the manufacturing process, such as microbeads for cell selection. https://lnkd.in/ejQ4WGdJ.