ARCHI-CARD (I2MC-UMR1297)

The physiologic response of an organ basically relies on a complex interplay between the different cell types structuring its tissue. At the cellular level, the response arises from the plasma membrane through different receptors, channels, pumps… that integrate and process the extracellular stimuli (chemical, mechanical). Alteration of the plasma membrane response is the hallmark of a number of pathological conditions. Now, how the plasma membrane and the overall cell architecture behave in such pathologies and what is the impact on the surface organization and functions of the proteins inserted in the plasma membrane still remain poorly understood. This is however of major interest in pharmacological medicine since most marketed drugs target these plasma membrane proteins. In this context, the research program of our team focuses on understanding the relationship between the architecture of cardiac tissue (more precisely of the cardiac contractile cells) on the function and pharmacology of the heart and but also on the brain. Our specific interests are subdivided in three main projects all around the notion of heart architecture: Identification of the molecular determinants of adult cardiomyocyte morphology & cardiac tissue organization, Characterization of the Heart / Brain axis and Exploration of cardiac cell surface GPCR architecture as a molecular basis underlying biased agonism efficacy of ligands (pharmacology of GPCR). Our team is highly interdisciplinary integrating people from basic and medical research. As a consequence, our approach also relies on a high interdisciplinarity starting from the identification of the molecular/cellular mechanisms to the integration in animal models but also in humans thanks to our collaboration with the Toulouse University Hospital.

Site web

http://www.i2mc.inserm.fr/index.php/fr/equipes-de-recherche/equipe-8

Lien externe pour ARCHI-CARD (I2MC-UMR1297)

Secteur

Services de recherche

Taille de l’entreprise

11-50 employés

Siège social

Toulouse

Type

Administration publique

Fondée en

2011