INEM - Institut Necker Enfants Malades

The INEM 10-Year Anniversary Symposium, Molecular and Cellular Metabolism in Health and Disease, has officially concluded! 🎉 Over the past two days, we welcomed inspiring keynote lectures, thought-provoking talks, and dynamic discussions across five thematic sessions. We also celebrated the contributions of young researchers during Flash Talk sessions. This event brought together leading researchers to share cutting-edge advances and explore the latest developments in the field of metabolism. We extend our heartfelt thanks to all the speakers, attendees, and volunteers who made this milestone event a success. Your enthusiasm and contributions continue to drive our mission forward. Here’s to many more years of discovery and innovation at INEM! 🧬✨ #INEM10YEARS #INEM2024 INSERM Inserm : Paris & Île-de-France Université Paris Cité Faculté de Santé - Université Paris Cité CNRS CNRS Délégation Île-de-France Villejuif

[CAREER] Postdoc position in Cell biology of liver disease 🔍 Project Focus: investigate the regulation and role of mitochondria-associated membranes (MAMs) in the liver’s constituent cell types during the development of metabolic dysfunction-associated steatotic liver disease (MASLD). 📍Location: INEM - Institut Necker Enfants Malades - IMMEDIAB lab 📢 Job descriptions and application instructions are provided in this post. 🤔 Curious or have questions? Don't hesitate to reach out for an informal chat. Fawaz Alzaid 📩 Apply now or share this opportunity with your connections who might be a great fit!

🌟 Congratulations to Mario Pende, recipient of the Gaston Rousseau Prize from the Académie des sciences! We are proud to announce that Mario Pende, head of the Cell growth control by nutrients lab, has received the prestigious Gaston Rousseau Prize for his research on nutrient metabolism and its effects on cell growth, proliferation, and senescence. His work has shed light on metabolic changes that explain why senescent cells accumulate fat in lipid droplets rather than using it for cell membrane construction during growth. The Gaston Rousseau Prize, established in 1966, is a biennial award dedicated to supporting and recognizing scientific research that promotes human well-being, particularly in areas like disease treatment and prevention, including cancer. Each year, with the support of private donors, state organizations, and companies, the Académie des sciences awards nearly 80 prizes covering all scientific fields, from fundamental to applied research. Many excellent candidates are considered for these awards, selected by juries under a regulation framework to avoid conflicts of interest. Congratulations, Mario, on this well-deserved recognition! 👏🎉 🔗 Learn more about the research in the Pende lab: https://lnkd.in/dJYvgwUf INSERM Inserm : Paris & Île-de-France Université Paris Cité CNRS CNRS Délégation Île-de-France Villejuif Institut de France ****** 🌟 Nous sommes fiers d'annoncer que Mario Pende est lauréat du prestigieux Prix Gaston Rousseau de l'Académie des sciences, pour ses recherches sur le métabolisme des nutriments et son impact sur la croissance, la prolifération et la sénescence cellulaires. Ses travaux ont mis en lumière des changements métaboliques expliquant pourquoi les cellules sénescentes accumulent la graisse dans des gouttelettes lipidiques plutôt que de l'utiliser pour construire des membranes cellulaires lors de la croissance et la prolifération. Prix biennal créé en 1966, le prix Gaston Rousseau est destiné à subventionner ou récompenser toutes recherches scientifiques tendant au mieux-être de l’humanité et, en tout premier lieu, la guérison des maladies. Grâce à la générosité de donateurs privés, d’organismes d’État ou d’entreprises, l’Académie des sciences remet, chaque année, près de 80 prix couvrant l’ensemble des domaines scientifiques, aussi bien fondamentaux qu’appliqués. De nombreux candidats d’excellence sont considérés pour ces prix. Leur sélection est opérée par des jurys fonctionnant dans le cadre d’un règlement excluant la possibilité de conflits d’intérêt. Félicitations, Mario, pour cette belle reconnaissance ! 👏 🔗 Plus d'infos sur les travaux du laboratoire Pende: https://lnkd.in/dKrkf2Mq INSERM Inserm : Paris & Île-de-France Université Paris Cité CNRS CNRS Délégation Île-de-France Villejuif Institut de France

[CAREER] Looking for postdoctoral opportunities in immunology and neuroinflammation? The "Immunity in Health and Disease" lab, led by Simon Fillatreau at INEM - Institut Necker Enfants Malades is recruiting for two exciting positions: 1️⃣ Postdoctoral Researcher in the biology of microglia in neuroinflammatory disease Explore the molecular networks guiding microglia's roles in inflammation and CNS regeneration using cutting-edge tools like scRNAseq and genetic models of multiple sclerosis. 2️⃣ Postdoctoral Researcher – Development of a novel regulatory T cell therapy for Type 1 Diabetes (European project ARTiDe) Develop TCR-engineered Tregs to target autoimmune responses in T1D. This European consortium project includes advanced single-cell analyses, humanized models, and innovative therapeutic strategies. 📍 Both positions are based in Paris, France, offering a vibrant research environment and access to state-of-the-art facilities. 🔗 Learn more about each position: Biology of microglia position: https://lnkd.in/dx__by2P Regulatory T cell therapy for T1D position: https://lnkd.in/dxT-QKMV 👉 Learn more about the Immunity in Health and Disease lab: https://lnkd.in/dVXtCacF 📩 Apply now or spread the word to join us at the forefront of immunity research! Université Paris Cité INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif

🎉 Congratulations to Meryem B. Baghdadi, recipient of the 2024 ATIP-Avenir Award! We are proud to celebrate Dr. Baghdadi's recognition with the prestigious #ATIP-Avenir Award supported by Fondation Bettencourt Schueller, for her research on the mechanical properties of the intestinal stem cells niche and their role during embryonic development and in disease. This award not only underscores the excellence of her project but also supports the establishment of her independent research group at INEM - Institut Necker Enfants Malades. Since 2005, the Fondation Bettencourt Schueller has been a partner of the INSERM Avenir program. In 2009, the Avenir program merged with the ATIP program by the CNRS. The Foundation has since supported the ATIP-Avenir program which promotes the return or settlement in France of very high-level young researchers, with a research project of exceptional quality, and wishing to create their own team. Welcome to INEM, Meryem, and congratulations on this well-deserved recognition! 🌟 📷: FRANCK FERVILLE / Agence VU' for Fondation Bettencourt Schueller 🎥: Discover Meryem Baghdadi's inspiring journey in this video by Lucie Clarysse, narrated by Elodie Chabrol, PhD: https://lnkd.in/ddK3i3k9 🔗 Learn more: https://lnkd.in/deRNa6vu INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif Université Paris Cité #atipavenir #talentsfondationbettencourt ******** 🎉 Félicitations à Meryem B. Baghdadi, lauréate du Prix #ATIP-Avenir 2024 ! Nous sommes heureux d'annoncer que Dr. Baghdadi est lauréate du prestigieux prix ATIP-Avenir, soutenu par la Fondation Bettencourt Schueller pour ses travaux sur les propriétés mécaniques de la niche des cellules souches intestinales et leur rôle au cours du développement embryonnaire et dans les maladies. Cette distinction souligne l'excellence de son projet et soutient la création de son équipe de recherche indépendante à l’INEM - Institut Necker Enfants Malades. Depuis 2005, la Fondation Bettencourt Schueller est partenaire du programme Avenir de l’INSERM. En 2009, le programme Avenir a fusionné avec le programme ATIP du CNRS. La Fondation soutient depuis le programme ATIP-Avenir qui favorise le retour ou l’installation en France de jeunes chercheurs de très haut niveau, porteurs d’un projet de recherche de qualité exceptionnelle, et désireux de créer leur propre équipe. Bienvenue à l’INEM, Meryem, et toutes nos félicitations pour cette belle reconnaissance ! 🌟 📷: FRANCK FERVILLE / Agence VU' pour La Fondation Bettencourt Schueller 🎥: Découvrez le parcours inspirant de Meryem Baghdadi dans cette vidéo réalisée par Lucie Clarysse, avec la narration d'Elodie Chabrol, PhD : https://lnkd.in/ddK3i3k9 🔗 En savoir plus : https://lnkd.in/d4EnUKCi INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif Université Paris Cité #atipavenir #talentsfondationbettencourt

[EVENT] Countdown to the INEM 10-Year Anniversary Symposium! In just one week, the Institut Necker Enfants Malades will celebrate its 10-year anniversary with a two-day symposium: Molecular and Cellular Metabolism in Health and Disease. 🗓️ When: November 21–22, 2024 📍 Where: Institut Necker Enfants Malades (160 rue de Vaugirard, 75015 Paris) - Amphithéâtre 1 This milestone event will feature: 🎤 Three keynote lectures, including Bana Jabri (University of Chicago Institut Imagine), Yasmine Belkaid (Institut Pasteur) and Kivanç Birsoy (The Rockefeller University). 📚 Five thematic sessions featuring distinguished speakers: - Neuro-metabolism: franck oury, Clemence Blouet, PhD, Paolo Giacobini - Metabolism-host interaction: Nathalie Delzenne, Eran Segal Pamela Schnupf - Cellular trafficking and metabolic signature: Volker Haucke Ganna Panasyuk, Karen Vousden - Adipose tissue metabolism: Mario Pende, Mikael Rydén, Christian Wolfrum - Immuno-metabolism: Florent Ginhoux, David Sancho, Simon Fillatreau ⚡Flash Talks: Highlighting emerging research from young scientists. We look forward to welcoming our speakers and attendees as we celebrate a decade of groundbreaking research in metabolism. 📄 Full program attached below! INSERM Inserm : Paris & Île-de-France Université Paris Cité Faculté de Santé - Université Paris Cité CNRS CNRS Délégation Île-de-France Villejuif #INEM2024 #INEM10YEARS

🚨 Position Still Open: Postdoctoral Fellow in T Cell Therapy for Type 1 Diabetes If you’re passionate about advancing T Cell therapy, this could be your opportunity! We’re still seeking a postdoctoral researcher to join the Immunity in Health & Disease Lab (Simon Fillatreau) as part of the ARTiDe project, working on innovative TCR-engineered Treg cell therapies for Type 1 Diabetes (T1D). 🔬 Position Highlights: - Contribute to groundbreaking T1D research - Join a collaborative, international team - Based in a state-of-the-art research environment 🔗 For full details and to apply: https://lnkd.in/dxT-QKMV Please share this post to help spread the word! Applications are being reviewed on a rolling basis. Université Paris Cité INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif

💙 Stepping Up for Multiple Sclerosis Research Proud of our INEM colleagues who participated in the run against multiple sclerosis, organized by France Sclérose en Plaques! 🏃🏼♀️ 🎉 Special congratulations to Nicole Stram for winning the race, and a big shout-out to Cuc Bui Thi, Yanli Tong, Zhiguo WU, and Mohamed El Behi from the Immunity in Health & Disease team (led by Simon Fillatreau) for their engagement. Their dedication to advancing research and supporting patients is a reminder of our shared mission. Kudos to all, and thank you to France Sclérose en Plaques for bringing us together for such a great cause! 👏 🌐 Learn more about the Fillatreau lab and its research here: https://lnkd.in/dS_2-NqG Université Paris Cité Faculté de Santé - Université Paris Cité INSERM Inserm : Paris & Île-de-France CNRS CNRS Formation Entreprises

[PUBLICATION] The role of Notch signaling in macrophage-driven inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD/MASH) is now clearer! 🔍 In MASLD, liver macrophages—resident Kupffer cells and monocyte-derived macrophages—display diverse inflammatory effects that shape disease severity and progression. 🔍 Using single-cell RNA sequencing (scRNA-seq) and fate mapping, Wei Guo et al. reveal how the Notch-RBPJ signaling pathway regulates the monocyte-to-macrophage transition. 🔍 RBPJ deficiency reduces pro-inflammatory macrophage activity and promotes lipid uptake through elevated CD36 expression in Ly6Clo monocytes, enhancing their protective interactions with endothelial cells. 💡 These findings mark a key step toward understanding macrophage differentiation and offer new therapeutic strategies for MASH treatment. 🤝 This work was made possible through a remarkable collaboration across leading institutions in immunology, oncology and metabolic sciences in Europe and Asia, with contributions from INEM’s Nicolas Venteclef and Camille Blériot. 🔗 For more insights, explore the full study in Immunity: https://lnkd.in/d3JzRk3e Université Paris Cité INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif Gustave Roussy Shanghai Jiao Tong University School of Medicine A*STAR - Agency for Science, Technology and Research University of Surrey Tsinghua University

🎉 Congratulations to the Panasyuk lab (Mechanisms of nutrient sensing - Ganna Panasyuk) at INEM - Institut Necker Enfants Malades for securing the ANR-PRCI grant, a collaborative project co-funded by ANR, the French National Research Agency and Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation. 🔍 The CoMeT consortium unites the Panasyuk lab’s expertise in nutrient signaling with Dominik Lutter's lab specialising in computational analysis at Helmholtz Munich and Florian Büttner's lab known for its innovation in machine learning and data integration (Goethe-Universität Frankfurt a. Main, DKFZ German Cancer Research Center). Together, this multidisciplinary team will develop cutting-edge computational tools to study how nuclear nutrient signalling regulates gene expression during metabolic challenges, advancing our understanding of metabolic adaptation in health and disease. 👏🏼 A well-deserved recognition for the Panasyuk team and all the partners involved. We look forward to the impactful discoveries that this project will bring! 🌐 Learn more about the Panasyuk lab and its research here: https://lnkd.in/dVZ7vP5C Université Paris Cité INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif