Great insights from Quentin Lecocq at #ESGCT 🙏 📢 If you're interested in discussing these latest advancements or exploring how we can support your preclinical developments in gene and cell therapies, feel free to reach out through LinkedIn. Our solutions are tailored to accelerate your projects and we’d love to connect and share more details. #CART #celltherapy
💡 Exciting insights from cell and gene therapy developpers at this years European Society of Gene and Cell Therapy congress in Rome! I had the pleasure of hearing from several leaders in the field of cell therapy, and I wanted to share some highlights: 🌟 tLNPs for CAR: Jacek Lubelski (Nanocell Therapeutics, The Netherlands) presented promising preclinical in vivo efficacy data on their dual target cell-directed, non-viral transposase-based gene delivery technology for in vivo CAR-T cell generation. A potential stepping-stone towards affordable CAR-T cell therapies for future patients! 🌟 TRAC-CAR-T cells: William A. Nyberg (UCSF/Karolinska Institutet) presented their work on in vivo site-specific engineering to generate TRAC-CAR-T cells, showcasing how the advantages of TRAC targeting and engineered delivery vehicles (EDVs) minimizing immunogenicity and achieving efficient nuclear delivery, potentially setting a new standard in precision engineering of CAR-T cells. 🌟 Q-CAR-T cells for allergy indications: Tali Stauber (Tel Aviv University) introduced Q-CAR-T cells with promising proof-of-concept data, demonstrating their ability to destroy IgE-class switched B cells. This development holds promise as a safe, robust treatment for patients suffering from severe allergies, potentially offering a life-long therapeutic solution. 🌟 pDC-like cell therapy in cancer: Anders Laustsen (UNIKUM Therapeutics, Denmark) highlighted the unique approach for their lead candidate PIRC-100, a novel cell therapy targeting oncology. Leveraging a proprietary cell culture protocol, the cells resemble plasmacytoid dendritic cells and feature the capacity to modulate immune responses in the tumor microenvironment (TME) through STING-promoted inflammation. The potential for translating these innovations into clinical solutions is vast, and I’m excited to see where the field is heading! 📢 If you're interested in discussing these latest advancements or exploring how we can support your preclinical developments in gene and cell therapies, feel free to reach out through LinkedIn. Our solutions are tailored to accelerate your projects and I’d love to connect and share more details. JC Discovery Yecuris Corporation JANVIER LABS European Society of Gene and Cell Therapy #jcdiscovery #CART #celltherapy