Can lymphoid organs-on-chip be used to evaluate the effectiveness of booster vaccines?
🧫Pasteur Institute researchers led by Lisa Chakrabarti have developed a "lymphoid organ-on-chip" technology that simulates the human immune system's response to booster vaccines. This system mimics the interaction of human immune cells—specifically B and T cells—in response to vaccine antigens. These cells can cluster and activate within the chip, producing antibodies that neutralize SARS-CoV-2.
🦠The system's capability to handle various immune cell types and its response to mRNA COVID vaccines has demonstrated variability in immune responses based on different donors' blood. This variability reflects the diverse immunological backgrounds found in human populations, making the organ-on-chip a valuable tool for preclinical vaccine testing, especially in adapting to the dynamic nature of the SARS-CoV-2 pandemic.
Credit : https://lnkd.in/gd6dUgAe
Below : After exposing the lymphoid organ-on-chip to viral proteins, activated T cells (in purple) and B cells (in cyan) cluster together to promote antibody production, just as they do in real lymphoid organs.