SMARTOX

Meet SB-PEPTIDE at the Sociedade Portuguesa de Imunologia (SPI) XLIX Annual Meeting 2024 in Porto, Portugal, from April 17th to 19th. We are very happy to participate in this event for the second time in a row and we are looking forward to talk to regulars as well as to meet this year’s new participants! Discover our range of expertise around peptide synthesis, engineering, express syntheses for immuno-oncology applications and much more. You might even find some funny goodies to take at work or at home when visiting us! 😉 https://lnkd.in/gUHu7Xfh #Peptide #SPI #Immunooncology #Portugal

🔬 We are thrilled to announce that our co-founder and scientific adviser, Michel De Waard, has contributed to a groundbreaking publication in the esteemed scientific journal BMC Complementary and Alternative Medicine and Therapies. 🎉 📚 Titled "Immunomodulatory effects of epiphytic Loranthus micranthus leaf extracts collected from two host plants: Psidium guajava and Parkia biglobosa" this study sheds light on the potential of natural immunomodulators in replacing current chemotherapy drugs with severe side effects. 🌟 Michel and collaborators’ meticulous research explores the immunomodulatory effects of Loranthus micranthus leaves extracts on innate and adoptive immune responses, as well as their impact on cyclophosphamide-induced myelosuppression in rats. 🔍 The findings reveal an abundance of pharmacologically relevant phytochemicals in both Loranthus micranthus leaf extracts, particularly in Psidium guajava. Moreover, the extracts exhibited promising immunostimulatory properties without adverse acute toxicity effects. 💡 Key discoveries include the extracts' ability to enhance total leukocyte count, differential leukocyte counting, and primary/secondary antibody titers, surpassing even the effects of the standard drug levamisole. Notably, Loranthus micranthus leaf extracts from Psidium guajava demonstrated superior immunomodulatory actions compared to the one extracted from Parkia biglobosa, indicating its potential as a potent immunostimulant. 🔬 This research not only paves the way for the development of safer alternatives to current immunomodulatory drugs but also opens new avenues for exploring natural compounds in combating chronic diseases. 🎓 Congratulations to Michel De Waard and the entire research team for their significant contribution to advancing scientific knowledge in immunology and pharmacology! 🌟 🔗 Idoko, N.D., Chukwuma, I.F., Nworah, F.N. et al. Immunomodulatory effects of epiphytic Loranthus micranthus leaf extracts collected from two host plants: Psidium guajava and Parkia biglobosa. BMC Complement Med Ther 24, 7 (2024). https://lnkd.in/dkzJbm42 #SMARTOX #Research #Immunology #Pharmacology #ScientificDiscovery #NaturalMedicine #AcademicPublication #BMCComplementaryMedicineAndTherapies

🌟 Exciting News! 🌟   We are thrilled to announce that our expertise in custom peptide synthesis has been recognized once again! 🎉   We are honored to have been cited as a trusted supplier of micropeptides in a recent article published by MDPI. The article explores the role of micropeptides in various biological processes, shedding light on their potential applications in research and therapeutics. From understanding cellular signaling pathways to developing novel therapies, micropeptides hold immense promise in advancing scientific discoveries.   Check out the article here: https://lnkd.in/dWj5qCc5   At SB-PEPTIDE, we strive to provide tailored solutions to researchers and professionals worldwide. Whether you're in need of micropeptides or any other custom peptides, we've got you covered!   Explore our 10 days express synthesis service and experience the convenience of rapid peptide synthesis for your research projects: https://lnkd.in/eiz-BXv   Thank you to our team for their hard work and dedication, and to the researchers who trusted us as their peptide synthesis partner. We look forward to supporting more innovative projects in the field of peptide science.   Drop a thumb if you liked this post and stay tuned for more outbreaking news !   #PeptideSynthesis #Micropeptides #CustomPeptides #Research #Innovation #MDPI #Science #Biotechnology

New citation of a SMARTOX peptide in Nature Communications :   Nat Commun. 15: 54 (2024). “Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine. doi: 10.1038/s41467-023-43502-w”   --   🔬🧬 Exciting news alert for research in cardiac physiology !   In this recent publication, Pietro Mesirca and collaborators illustrate that calciseptine is selective for the Cav1.2 L-type current over the Cav1.3 L-type channel. By using this Cav1.2 selective tool, the group unravels the heart's intricate mechanisms by illustrating that the peptide affects contraction by leaving pacemaker activity untouched.   Dihydropyridines (DHPs) are typically used as Cav1 agonists or antagonists. However, their lack of selectivity due to the highly similar DHP binding sites present on both Cav1.2 and Cav1.3 calcium channel isoforms does not easily allow distinguishing the physio-pathological roles underpinning each channel function. For this reason, calciseptine can now be considered as a handy peptide tool, selective for Cav1.2, to differentiate its function from Cav1.3 in the heart or other tissues that would express these channel types. The next step will probably the discovery of a peptide selective for Cav1.3.   In this study, BeKm1 peptide, another peptide from SMARTOX, was used to selectively block HERG current. -- If you also want to revolutionize cardiac pharmacology and more, visit our website to order this toxin peptide or another : https://lnkd.in/dUqcYD6Q Drop a thumb and share this post if you liked it ! 😉 #Research #ToxinScience #Peptides #Cardiology

Happy New Year to Our Esteemed Customers Worldwide! 🌟 As we usher in the new year, SB-PEPTIDE extends warm wishes and gratitude to its valued customers across the globe. 🌎 Your continued trust and collaboration have been instrumental in our journey, and we look forward to another year of innovation, excellence, and shared success. -- 🌟 Rejoignez Notre Équipe - Deux Opportunités Passionnantes vous Attendent ! 🌟 En ce début d'année 2024, nous sommes ravis d'annoncer deux opportunités d'emploi à pourvoir au plus vite 🚀 1️⃣Technicien Chimiste (H/F) - Contrôle Qualité QC Passionné par la chimie et le contrôle qualité ? Rejoignez notre équipe technique et contribuez à maintenir la qualité de nos peptides sur le marché ! 2️⃣Technico-Commercial (H/F) Vous êtes un chimiste/biochimiste bilingue avec un flair pour la vente ? Découvrez le rôle passionnant de Technico-Commercial à nos côtés et contribuez à notre succès sur le marché ! Prêt à sauter le pas ? Consultez les détails de nos offres sur notre site carrière (https://lnkd.in/gjAdvYgy) et rejoignez-nous pour façonner l'avenir des solutions peptidiques ! 🚀 #OpportunitésEmploi #RecrutementEnCours #SBPEPTIDE #RejoignezNotreÉquipe #NouvelAnNouvellesOpportunités #SMARTOX