Post de Réseau canadien pour l'usage approprié des médicaments et la déprescription

Lancer le test innovant #myEDIT-B, dans un domaine de la médecine, la #psychiatrie, où il n'existe pas encore : - ni référence de marché en biologie, - ni habitude de prescription de test d'aide au diagnostic en santé mentale (et pour cause), - ni remboursement pour les patients, c'est à la fois - une #fierté : celle d'être pionnier, - un #honneur : celui travailler avec des chercheurs, des experts médicaux et des partenaires aussi engagés, - un #challenge véritable : partager les éléments de preuves scientifiques du test à des médecins dubitatifs ou circonspects, faire l'objet de controverses, expliquer tous les jours les bénéfices et les conditions du test à des patients en souffrance et demandeurs malgré les réserves de leur médecin. bravo à ALCEDIAG pour ses travaux de recherche et la reconnaissance européenne de ses résultats concrets pour le développement de la psychiatrie de précision, au bénéfice des patients. #bipolarité #dépression

Mental Health Challenges Among Physicians: Impacts of Burnout and Depression on Patient Care   In recent years, the well-being of physicians has become an increasingly concerning topic due to the numerous mental health challenges these professionals face. The study Burnout, Depression, and Diminished Well-Being among Physicians, published by the New England Journal of Medicine, reveals that conditions such as acute and chronic stress, trauma, moral distress, moral injury, burnout, and depression not only affect physicians but also have direct consequences on the quality of patient care.   When a physician experiences burnout, emotional exhaustion and continuous stress can lead to decreased empathy and attentiveness, undermining the doctor-patient relationship. The lack of energy and focus often associated with burnout increases the risk of medical errors, thereby compromising patient safety. Overwork and limited decision-making autonomy also contribute to professional frustration, which may result in less accurate diagnoses and a less humanized approach to care.   Depression is another critical issue, particularly among physicians in training. The study reveals that during residency, depression rates increase five to six times compared to pre-residency levels, with approximately 25% to 30% of residents experiencing depressive symptoms at some point during their training. Extreme pressure and long work hours not only affect physicians' mental health but also impact the quality of care they provide. Physicians under emotional distress may struggle with making quick and decisive judgments, which are crucial in emergency situations.   This scenario highlights the urgent need for interventions that promote physician well-being. Reducing working hours and providing greater psychological support can not only improve the health of these professionals but also ensure safer and higher-quality patient care. Investing in the well-being of physicians is, ultimately, an investment in patient health and safety, strengthening the healthcare system as a whole.     Source: Guille, C., & Sen, S. (2024). Burnout, Depression, and Diminished Well-Being among Physicians. New England Journal of Medicine, 391(16), 1519-1527. https://lnkd.in/dHD-MrPW    Available in: https://lnkd.in/dwaW-Qe3

💊 les anticonvulsivants sont-ils efficaces dans la prise en charge des symptômes psycho-comportementaux compliquant les troubles neurocognitifs majeurs (i.e. démence) ? C'est à cette question que tente de répondre cette revue systématique de littérature parue tout récemment dans le prestigieux American Journal of Geriatric Psychiatry (auteurs: Sophiya Benjamin, Joanne Man-Wai Ho, Jennifer Tung, Saumil Dholakia, Howard An, Tony Antoniou, Stephanie Sanger, John W Williams Jr) 📝 Dans cette revue, le niveau de preuve des études analysées était jugé faible. Les molécules considérées étaient des anticonvulsivants non-benzodiazépines (carbamazepine, oxcarbazepine, valproate, topiramate). ⛔ Les auteurs concluent qu'en l'état actuel des publications, il est peu probable que cette classe médicamenteuse soit efficace dans cette indication et qu'elle présente une haute prévalence d'effets indésirables.

📢 Exciting Research Update! 📢 I am thrilled to share the key findings from two recent studies that offer valuable insights. 1) Association of Healthy Ageing Index (HAI) with Health-Related Outcomes in a Multi-Ethnic Cohort from Singapore (collaboration with Dr Saima Hilal and her MPH students) - Published in BMC Geriatrics, 2024 This study, led by Fauzi et al., investigates the association between the Healthy Ageing Index (HAI) and various health-related outcomes in a multi-ethnic cohort from Singapore. Key findings include: - Lower HAI scores were associated with older age, Malay and Indian ethnicities, unemployment, high BMI, and histories of coronary heart disease, hypercholesterolemia, tumors, and TIA/stroke. - Higher HAI scores were associated with being female and having higher education levels. - Lower HAI scores were significantly associated with lower Ankle-Brachial Index (ABI), higher Kessler Psychological Distress Scale (K10) scores, and problems with mobility and anxiety/depression as measured by the EQ-5D-5L questionnaire. - The HAI shows promise as an evaluation method for assessing peripheral artery disease (PAD), overall muscle strength, and health-related quality of life (HRQoL) in a population-based setting. 2) Effectiveness of e-Mental Health Interventions Among Healthcare Professionals (collaboration with Dr Vivien Wu, and researchers from Huazhong University of Science and Technology, Queen’s University Belfast, and Hong Kong Metropolitan University) - Published in Systematic Reviews, 2024 In another impactful study by Zhang et al., the effectiveness of e-mental health interventions on reducing anxiety and improving the quality of life among healthcare professionals was evaluated. Highlights from this systematic review and meta-analysis include: - Significant improvement in anxiety and depression symptoms among healthcare professionals using e-mental health interventions. - Different types of e-mental health interventions, such as mindfulness-based interventions, cognitive-behavioral therapy (CBT), and stress management programs, were effective. - The study underscores the need for future high-quality, large-scale research to further validate these findings and optimize intervention strategies. These studies highlight the promising potential of innovative interventions in improving mental health and overall well-being across different populations. The findings are crucial for developing targeted strategies to support healthcare professionals and older adults, ensuring better mental health outcomes and quality of life. 👉 Read more about these studies: Fauzi et al. (2024) BMC Geriatrics: https://lnkd.in/dBPB7Aez Zhang et al. (2024) Systematic Reviews: https://lnkd.in/dtBbQKPG #MentalHealth #HealthcareProfessionals #OlderAdults #SystematicReview #MetaAnalysis #EMentalHealth #PublicHealth #Research

Last Month we had our 3rd annual meeting of the EDIT-B consortium in Copenhagen. This gathering marked the culmination of three years of dedicated work, focused on advancing precision psychiatry and improving the lives of patients with bipolar disorder and the people who care about them. While our consortium officially concludes at the end of the year, we are incredibly proud to announce a major milestone achieved ahead of schedule: the introduction of the EDIT-B test into clinical routine in Italy and France. This groundbreaking blood test, a result of strategic collaboration with SYNLAB in Europe, represents a significant step forward in helping physicians to diagnose bipolar disorder. EDIT-B utilizes RNA sequencing and artificial intelligence to differentiate between bipolar disorder and depression with over 80% sensitivity and specificity. This innovative diagnostic tool has the potential to significantly reduce the diagnostic delay, which currently averages 8-10 years, and expedite access to appropriate treatment for many individuals. We are deeply grateful to all our consortium partners for their unwavering commitment to this project. Our collective efforts have brought us closer to a future where mental health care is personalized, precise, and empowers both patients and healthcare professionals. We are excited to continue our work in advancing precision psychiatry and improving patient care. Stay tuned for updates on our progress and future endeavors! SYNLAB France SYNLAB Italia SYNLAB International Hospital Clínic de Barcelona Parc Sanitari Sant Joan de Deu GHU Paris psychiatrie & neurosciences ProductLife Group Capital Region of Denmark ALCEN EIT Health EIT Health France EIT Health Spain EIT Health InnoStars Eduard Vieta Jeff Zarp Lars Kessing Josep Maria Haro Chantal Henry Dinah Weissmann Alexandra Prieux Diana Vetter Aurore S. ANDRE Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Fundació Clínic per a la Recerca Biomèdica Fundació de Recerca Sant Joan de Déu Laurence Ricard #PrecisionPsychiatry #MentalHealthcare #MentalHealth #IVD #CipolarDisorder

"The Fine Art (and Science) of Nonprescribing" Cet article explore l'importance de la non-prescription et de la déprescription de médicaments en psychiatrie, en particulier lorsque la psychothérapie est une alternative de première ligne. Il s’agit d’imaginer comment ne pas traiter tout de suite à l’aide de médicaments, comment éventuellement diminuer la poly médication, comment développer une approche complémentaire où pharmacologie et psychothérapie dialoguent. L'auteur souligne que bien que les médicaments psychiatriques puissent être vitaux, ils comportent souvent des effets secondaires négatifs et des difficultés de sevrage. Il plaide pour un équilibre entre les traitements médicamenteux et non médicamenteux, en fonction des besoins spécifiques du patient. Les conclusions 1. Priorité à la psychothérapie: Pour de nombreux troubles psychiatriques, la psychothérapie est souvent le traitement de première ligne recommandé, offrant des alternatives efficaces aux médicaments. 2. S’essayer à la déprescription : réduire ou cesser les médicaments lorsque les bénéfices ne surpassent plus les risques est essentiel, particulièrement pour éviter les effets secondaires et les difficultés de sevrage. 3. Polypharmacie et sur prescription : Bien que certains médicaments soient sous-utilisés (comme le lithium pour les troubles bipolaires), d'autres, comme les antipsychotiques, sont souvent surprescrits, notamment dans les populations vulnérables. 4. Approche intégrative : La combinaison de traitements médicamenteux et non médicamenteux peut être la plus efficace dans certains cas, cela souligne l'importance d'une approche personnalisée et équilibrée en psychiatrie. https://lnkd.in/eXJ2kCs6

Join our webinar on Thursday and learn how lifestyle medicine can help healthcare workers look after their mental health and avoid burnout!

🚀 Nouvelle publication ! 🎉 Découvrez notre dernière étude sur la catatonie dans la démence ! 🧠✨ 🧠 Catatonie & Démence sont souvent associées. 🎯 Taux de rémission de la catatonie élevé grâce à des interventions personnalisées. 🔍 Réponse au traitement : elle varie selon le sous-type de démence, nous guidant vers une médecine plus précise. Thibaud Lebouvier #Science #Innovation #Démence #Catatonie #RecherchePsychiatrique Lien de l'article gratuit pendant 50 jours :

Les problèmes de communication peuvent être le signe d'un trouble de la santé mentale Consutlez l'article ici pour plus d'information: https://ow.ly/JuO850UaUOY McGill University #ProfessionSanté #Communication #Neurologie #Psychiatrie #SantéMentale #SantéPublique

https://lnkd.in/gAjPQdEa                                    Article title: Citicoline in Vascular Cognitive Impairment: Some Latest Evidences   Author(s): Pietro Gareri; Alberto Castagna   Journal: Annals of Alzheimer's and Dementia Care   Journal ISSN: 2692-448X Introduction: CDP-choline (cytidine-5′-diphosphate choline), also called citicoline, is one of the most frequently pre­scribed drugs for cognitive impairment in several European countries and worldwide [1–3]. In clinical practice, a number of different studies have shown that citicoline is effective in Parkinson’s disease, glaucoma, amblyopia, head trauma and cognitive impairment (CI) of diverse etiology, such as in CI following cerebrovascular disease [1-4]. #AlzheimersBiomarkers #AlzheimersDisease #AlzheimersDiseaseTreatment #AlzheimersDiseaseAmyloid #OnsetAlzheimers #AlzheimersTherapy #AlzheimersNeuroinflammation #AlzheimersDiabetes #FamilialAlzheimers #MicrogliaAlzheimers #DietAlzheimers #MemantineAlzheimers #AlzheimersDementia #AlzheimersDiseaseTau #AlzheimersDiseaseDiagnosis #AlternativeTreatmentsForAlzheimers #AlzheimersDiseaseRisk #ModelAlzheimersDisease #AlzheimersDiseasePathology #AlzheimersDiseaseDiabetes #AlzheimersDiseasePrevention #StressAlzheimersDisease #AlzheimersSigns #FrontotemporalDementia #VascularDementia #DementiaTherapy #LewyBodyDementia #DementiaCognitive #DementiaMusic #DementiaOccupational #DementiaParkinson #PhysicalDementia #DementiaTreatmentAndCare #DementiaDiagnosis #PrevalenceDementia #DementiaRiskAndPrevention #DementiaSymptoms #DementiaDepression #AdvancedDementia #SemanticDementia #RiskFactors #Age #FamilyHistory #Genetics #Heredity #GenesLinkedToAlzheimers #BrainHealth #HighBloodPressure #HighCholesterol #DamageToBrainCells #Hippocampus #CardiovascularRiskFactors #CoreMentalFunctions #Memory #CommunicationAndLanguage #AbilityToFocus #ReasoningAndJudgment #VisualPerception #DementiaCare #NonDrugTherapies #DementiaCaregiver #DementiaCaregiverBurden #DementiaCareMapping #DementiaCareNursing #DementiaCaregiverEducation #DementiaCareManagement #DementiaCaregiverIntervention #DementiaCaregiverDepression #EarlyOnsetDementiaCaregiver