Stoelting Europe

𝗧𝗵𝗲 𝗷𝗼𝘆𝘀𝘁𝗶𝗰𝗸 𝗰𝗼𝗻𝘁𝗿𝗼𝗹 𝗼𝗻 𝗦𝘁𝗼𝗲𝗹𝘁𝗶𝗻𝗴'𝘀 𝗺𝗼𝘁𝗼𝗿𝗶𝘇𝗲𝗱 𝘀𝘁𝗲𝗿𝗲𝗼𝘁𝗮𝘅𝗶𝗰 frame offers precise, intuitive navigation for researchers performing delicate stereotaxic procedures. Its ergonomic design ensures ease of use, allowing 𝘀𝗺𝗼𝗼𝘁𝗵, 𝗺𝘂𝗹𝘁𝗶-𝗮𝘅𝗶𝘀 𝗺𝗼𝘃𝗲𝗺𝗲𝗻𝘁 of the stereotaxic arm with minimal effort. This feature reduces the risk of hand fatigue and 𝗲𝗻𝗵𝗮𝗻𝗰𝗲𝘀 𝗰𝗼𝗻𝘁𝗿𝗼𝗹, 𝗽𝗮𝗿𝘁𝗶𝗰𝘂𝗹𝗮𝗿𝗹𝘆 𝗱𝘂𝗿𝗶𝗻𝗴 𝗶𝗻𝘁𝗿𝗶𝗰𝗮𝘁𝗲 𝗮𝗱𝗷𝘂𝘀𝘁𝗺𝗲𝗻𝘁𝘀 when arriving at your reference point. 𝗞𝗲𝗲𝗻 𝗼𝗻 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗺𝗼𝗿𝗲? 𝗔𝘀𝗸 𝗳𝗼𝗿 𝗮 𝗱𝗲𝗺𝗼 𝘁𝗼𝗱𝗮𝘆! https://lnkd.in/e8ebp7QU 𝗬𝗼𝘂 𝗰𝗮𝗻 𝗮𝗹𝘀𝗼 𝗳𝗶𝗻𝗱 𝗺𝗼𝗿𝗲 𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗼𝗻 𝗼𝗻 𝗼𝘂𝗿 𝘄𝗲𝗯𝘀𝗶𝘁𝗲: https://lnkd.in/d6x268GR

We’re excited to announce the launch of two new thermal probes from Stoelting, designed specifically for mice and rats. This innovation supports the growing need for enhanced animal welfare and improved research accuracy, ensuring that researchers can maintain ethical standards while achieving reliable results. Why the change? 💡Improved Animal Welfare: By customizing the probes for each species, we minimize discomfort, supporting ethical research practices. 💡Precision Matters: The new probes are designed to fit the unique anatomical differences between mice and rats, providing more accurate and consistent thermal readings. 💡Ethical Research: Our commitment to animal welfare ensures that your studies can be both ethical and precise. Our New Thermal Probes: ◾Stoelting Rectal Thermal Probe, Mouse (1.4mm dia.) Code: 53805 ◾Stoelting Rectal Thermal Probe, Rat (2.0mm dia.) Code: 53804 For more information on these products, visit: https://lnkd.in/dPBP4NKv At Stoelting, we’re proud to provide innovative tools that support ethical research practices and precision-driven results.

𝗗𝗶𝗱 𝘆𝗼𝘂 𝗸𝗻𝗼𝘄 𝘁𝗵𝗮𝘁 𝘆𝗼𝘂 𝗰𝗮𝗻 𝗮𝗱𝗱 𝗮 𝘀𝗲𝗰𝗼𝗻𝗱 𝗺𝗮𝗻𝗶𝗽𝘂𝗹𝗮𝘁𝗼𝗿 𝗮𝗿𝗺 𝘁𝗼 𝘆𝗼𝘂𝗿 𝘀𝘁𝗲𝗿𝗲𝗼𝘁𝗮𝘅𝗶𝗰 𝗳𝗿𝗮𝗺𝗲 𝗮𝗻𝘆 𝘁𝗶𝗺𝗲? Upgrading your existing stereotaxic frame with a second arm allows you to 𝗺𝗼𝘂𝗻𝘁 𝗮𝗻𝗱 𝗰𝗼𝗻𝘁𝗿𝗼𝗹 𝘁𝘄𝗼 𝗽𝗿𝗼𝗯𝗲𝘀 𝘀𝗶𝗺𝘂𝗹𝘁𝗮𝗻𝗲𝗼𝘂𝘀𝗹𝘆 improving precision and flexibility in your experiments. With two arms, 𝗲𝗮𝗰𝗵 𝗽𝗿𝗼𝗯𝗲 𝗰𝗮𝗻 𝗯𝗲 𝗶𝗻𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁𝗹𝘆 𝗮𝗱𝗷𝘂𝘀𝘁𝗲𝗱 𝗮𝗻𝗱 𝗰𝗼𝗻𝘁𝗿𝗼𝗹𝗹𝗲𝗱. This means you can perform complex procedures like targeting two distinct brain regions or applying varied techniques. The ability to independently 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲 𝗼𝗻𝗲 𝗮𝗿𝗺 𝘄𝗵𝗶𝗹𝗲 𝗺𝗮𝗶𝗻𝘁𝗮𝗶𝗻𝗶𝗻𝗴 𝗺𝗮𝗻𝘂𝗮𝗹 𝗼𝗿 𝘀𝗲𝗺𝗶-𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝗰𝗼𝗻𝘁𝗿𝗼𝗹 𝗼𝗳 𝘁𝗵𝗲 𝗼𝘁𝗵𝗲𝗿 adds even more versatility. 𝗞𝗲𝗲𝗻 𝗼𝗻 𝗸𝗻𝗼𝘄𝗶𝗻𝗴 𝗺𝗼𝗿𝗲? ▪️Information on our range of dual arm stereotaxic frames and additional manipulator arms is available on www.stoeltingeurope.com . ▪️You can also contact our experts via info@stoeltingeurope.com to identify a solution tailored for your purpose.

𝗗𝗼 𝗬𝗼𝘂 𝗞𝗻𝗼𝘄 𝗛𝗼𝘄 𝗩𝗮𝗹𝘂𝗮𝗯𝗹𝗲 𝘁𝗵𝗲 ANY-maze 𝗛𝗲𝗹𝗽 𝗦𝗲𝗰𝘁𝗶𝗼𝗻 𝗖𝗮𝗻 𝗕𝗲? With nearly 𝟯,𝟬𝟬𝟬 𝗽𝗮𝗴𝗲𝘀, over 𝟴𝟬𝟬 𝘁𝗼𝗽𝗶𝗰𝘀, and countless illustrations, the Help section is your go-to guide for mastering ANY-maze. 💻 With the Help content available offline on your computer (𝘯𝘰 𝘪𝘯𝘵𝘦𝘳𝘯𝘦𝘵 𝘤𝘰𝘯𝘯𝘦𝘤𝘵𝘪𝘰𝘯 𝘳𝘦𝘲𝘶𝘪𝘳𝘦𝘥), you always have quick and easy access to the information you need. 📚 Everything is clearly organized into chapters, and you can easily find what you need 𝘁𝘆𝗽𝗶𝗻𝗴 𝗶𝗻 𝘁𝗵𝗲 𝘀𝗲𝗮𝗿𝗰𝗵 𝗳𝗶𝗲𝗹𝗱 𝘀𝗶𝗻𝗴𝗹𝗲 𝘄𝗼𝗿𝗱𝘀 𝗼𝗿 𝗽𝗵𝗿𝗮𝘀𝗲𝘀 💡 𝗣𝗿𝗼 𝗧𝗶𝗽: the Help system is context-sensitive, so it automatically shows topics relevant to whatever you're working on when you switch from the Protocol to the Help page. 🖨️ What’s more, 𝘁𝗵𝗲 𝗰𝗼𝗻𝘁𝗲𝗻𝘁 𝗶𝘀 𝗳𝘂𝗹𝗹𝘆 𝗳𝗹𝗲𝘅𝗶𝗯𝗹𝗲: you can 𝗰𝗼𝗽𝘆, 𝘀𝗮𝘃𝗲, and 𝗽𝗿𝗶𝗻𝘁 any section you need for quick reference. 𝙏𝙖𝙠𝙚 𝙛𝙪𝙡𝙡 𝙖𝙙𝙫𝙖𝙣𝙩𝙖𝙜𝙚 𝙤𝙛 𝙩𝙝𝙞𝙨 𝙧𝙚𝙨𝙤𝙪𝙧𝙘𝙚 𝙖𝙣𝙙 𝙢𝙖𝙠𝙚 𝙮𝙤𝙪𝙧 𝘼𝙉𝙔-𝙢𝙖𝙯𝙚 𝙚𝙭𝙥𝙚𝙧𝙞𝙚𝙣𝙘𝙚 𝙨𝙢𝙤𝙤𝙩𝙝𝙚𝙧 𝙖𝙣𝙙 𝙢𝙤𝙧𝙚 𝙚𝙛𝙛𝙞𝙘𝙞𝙚𝙣𝙩! And if you need further assistance, don’t worry: our technical support team is here to help. If your computer is connected to the internet, you can contact support directly from within ANY-maze (𝘚𝘶𝘱𝘱𝘰𝘳𝘵 𝘱𝘢𝘨𝘦 > 𝘊𝘰𝘯𝘵𝘢𝘤𝘵 𝘵𝘦𝘤𝘩𝘯𝘪𝘤𝘢𝘭 𝘴𝘶𝘱𝘱𝘰𝘳𝘵) or simply email us at anymaze@stoeltingeurope.com 💶 And remember: 𝘄𝗲 𝗽𝗿𝗼𝘃𝗶𝗱𝗲 𝗳𝗿𝗲𝗲, 𝗹𝗶𝗳𝗲𝘁𝗶𝗺𝗲 𝘁𝗲𝗰𝗵𝗻𝗶𝗰𝗮𝗹 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝘁𝗼 𝗮𝗹𝗹 𝗔𝗡𝗬-𝗺𝗮𝘇𝗲 𝘂𝘀𝗲𝗿𝘀, even if you’re just trialing the system!

𝗗𝗲𝗺𝗲𝗻𝘁𝗶𝗮 𝗶𝘀 𝗮 𝗽𝗿𝗲𝘀𝘀𝗶𝗻𝗴 𝗴𝗹𝗼𝗯𝗮𝗹 𝗵𝗲𝗮𝗹𝘁𝗵 𝗰𝗼𝗻𝗰𝗲𝗿𝗻, 𝗺𝗮𝗻𝗶𝗳𝗲𝘀𝘁𝗶𝗻𝗴 𝗶𝗻 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀 𝗹𝗶𝗸𝗲 𝗺𝗲𝗺𝗼𝗿𝘆 𝗹𝗼𝘀𝘀, 𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻, 𝗮𝗻𝘅𝗶𝗲𝘁𝘆, 𝗮𝗴𝗶𝘁𝗮𝘁𝗶𝗼𝗻, 𝗮𝗻𝗱 𝗱𝗲𝗳𝗶𝗰𝗶𝘁𝘀 𝗶𝗻 𝘀𝗼𝗰𝗶𝗮𝗹 𝗰𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝘁𝗵𝗮𝘁 𝘀𝗲𝘃𝗲𝗿𝗲𝗹𝘆 𝗶𝗺𝗽𝗮𝗰𝘁 𝗱𝗮𝗶𝗹𝘆 𝗹𝗶𝗳𝗲. While Alzheimer's disease (AD) is the most common form, studying it in animal models remains challenging, as no 𝗽𝗲𝗿𝗳𝗲𝗰𝘁 𝗺𝗼𝗱𝗲𝗹 exists to fully replicate human complexity and lifestyle. Transgenic animal models raise ethical concerns and show significant differences from human pathology. Conversely, aged wild-type mice may better mimic human variability, though cognitive decline is inconsistent, making findings sometimes conflicting. Pharmacological models offer alternative insights; for example, the scopolamine model is limited to cholinergic neurons, while newer models like aftin-4 induce complex neurodegenerative processes. Aftin-4 disrupts mitochondrial function, alters amyloid precursor protein cleavage, and triggers neurotoxic effects, including Aβ1-42 production, inflammation, and cognitive impairment. This study, 𝘱𝘶𝘣𝘭𝘪𝘴𝘩𝘦𝘥 𝘰𝘯 𝘕𝘢𝘵𝘶𝘳𝘦 𝘚𝘤𝘪𝘦𝘯𝘵𝘪𝘧𝘪𝘤 𝘳𝘦𝘱𝘰𝘳𝘵𝘴, compared aftin-4-treated mice with aged mice (15+ months) through behavioral tests, measuring postmortem Aβ levels and markers of oxidative stress and glial activity. Notably, results showed consistent effects across both sexes, indicating generalizability. Testing included anxiety (EPM test), spatial memory (Y-maze), and sociability (three-chamber test). This work highlights the need for refined models to better understand and combat dementia. 𝗧𝗼 𝗿𝗲𝗮𝗱 𝗺𝗼𝗿𝗲 👉 https://lnkd.in/dSNaJkxx ******* We'd like to thank the authors for trusting our videotracking software ANY-maze for the behavioral tests. Many thanks for citing ANY-maze and Stoelting Europe

.... and here's the great news we anticipated! We're happy to welcome Laura Booth to the Stoelting Europe/ANY-maze sales team, as Sales and Marketing Support Specialist! Laura brings not only incredible passion and dedication that aligns with our shared vision, but also a genuine enthusiasm that makes collaboration even more exciting. 🙌 On top of that, we've already discovered we share so many interests beyond the job: we can't wait to build on this common ground as we work together! Aishwarya, Cinzia, and the whole team are eager to get started on this journey with you. 🚀 Welcome aboard, 𝗟𝗮𝘂𝗿𝗮: here’s to success and great memories ahead!

🎉 𝗧𝗵𝗮𝗻𝗸 𝗬𝗼𝘂 𝗳𝗼𝗿 𝟮,𝟬𝟬𝟬 𝗙𝗼𝗹𝗹𝗼𝘄𝗲𝗿𝘀! 🎉 We’ve hit 2,000 followers, and we couldn’t be more grateful! Every single one of you is part of a community that drives innovation, passion, and meaningful work. 𝙏𝙝𝙞𝙨 𝙢𝙞𝙡𝙚𝙨𝙩𝙤𝙣𝙚 𝙢𝙚𝙖𝙣𝙨 𝙖 𝙡𝙤𝙩 𝙩𝙤 𝙪𝙨, 𝙖𝙣𝙙 𝙞𝙩’𝙨 𝙖𝙡𝙡 𝙩𝙝𝙖𝙣𝙠𝙨 𝙩𝙤 𝙮𝙤𝙪𝙧 𝙨𝙪𝙥𝙥𝙤𝙧𝙩 𝙖𝙣𝙙 𝙚𝙣𝙜𝙖𝙜𝙚𝙢𝙚𝙣𝙩. Here’s to continued growth, collaboration, and shared success. Thank you for being on this journey with us!

🌟 𝗧𝗵𝗲 𝗦𝘁𝗼𝗲𝗹𝘁𝗶𝗻𝗴 / 𝗔𝗡𝗬-𝗺𝗮𝘇𝗲 𝗦𝗮𝗹𝗲𝘀 𝗧𝗲𝗮𝗺 𝗶𝗻 𝗘𝘂𝗿𝗼𝗽𝗲: 𝘄𝗵𝗼 𝘄𝗲 𝗮𝗿𝗲 🌟 At Stoelting Europe/ANY-maze, our commitment goes far beyond delivering precision and performance; our focus is on 𝗺𝗲𝗮𝗻𝗶𝗻𝗴𝗳𝘂𝗹 𝗲𝗻𝗴𝗮𝗴𝗲𝗺𝗲𝗻𝘁, 𝗲𝘅𝗰𝗲𝗽𝘁𝗶𝗼𝗻𝗮𝗹 𝘀𝘂𝗽𝗽𝗼𝗿𝘁, 𝗮𝗻𝗱 𝗮𝗱𝗱𝗶𝗻𝗴 𝘁𝗿𝘂𝗲 𝘃𝗮𝗹𝘂𝗲 to every project. 🛞 𝙒𝙝𝙖𝙩 𝙜𝙪𝙞𝙙𝙚𝙨 𝙤𝙪𝙧 𝙩𝙚𝙖𝙢? 𝙊𝙪𝙧 𝙘𝙤𝙧𝙚 𝙫𝙖𝙡𝙪𝙚𝙨: 🔹 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗙𝗶𝗿𝘀𝘁 – We put our customers at the heart of everything we do, taking the time to understand their unique needs and challenges. 𝘉𝘶𝘪𝘭𝘥𝘪𝘯𝘨 𝘮𝘦𝘢𝘯𝘪𝘯𝘨𝘧𝘶𝘭 𝘤𝘰𝘯𝘯𝘦𝘤𝘵𝘪𝘰𝘯𝘴 𝘪𝘴 𝘬𝘦𝘺, which often turns clients into more than customers. 🔹 𝗣𝗿𝗼𝗯𝗹𝗲𝗺-𝗦𝗼𝗹𝘃𝗶𝗻𝗴 𝗠𝗶𝗻𝗱𝘀𝗲𝘁 – Complex challenges are opportunities for growth. We love turning obstacles into 𝘪𝘯𝘯𝘰𝘷𝘢𝘵𝘪𝘷𝘦 𝘴𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘴 that simplify and elevate researchers' work. 🔹 𝗔𝗱𝗮𝗽𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆 & 𝗙𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆  – Our commitment lies in providing cutting-edge 𝘴𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘴 𝘵𝘢𝘪𝘭𝘰𝘳𝘦𝘥 𝘰𝘯 𝘺𝘰𝘶𝘳 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘯𝘦𝘦𝘥𝘴. Flexibility is our strength: 𝙟𝙪𝙨𝙩 𝙩𝙖𝙡𝙠 𝙩𝙤 𝙪𝙨! 🔹 𝗖𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗼𝗻 – Teamwork drives our success. Together, we ensure that every solution is thoughtful, every initiative is meaningful, so that every customer feels 𝘧𝘶𝘭𝘭𝘺 𝘴𝘶𝘱𝘱𝘰𝘳𝘵𝘦𝘥. 🔹 𝗜𝗻𝘁𝗲𝗴𝗿𝗶𝘁𝘆 – We stand by our commitments with 𝘵𝘳𝘢𝘯𝘴𝘱𝘢𝘳𝘦𝘯𝘤𝘺, 𝘳𝘦𝘭𝘪𝘢𝘣𝘪𝘭𝘪𝘵𝘺, 𝘢𝘯𝘥 𝘦𝘹𝘤𝘦𝘭𝘭𝘦𝘯𝘤𝘦, from start to finish. These values are what drive the Stoelting/ANY-maze sales team (Aishwarya Vishwanathan and Cinzia Boldi) 𝗛𝗼𝘄 𝗱𝗼 𝘆𝗼𝘂 𝘀𝗲𝗲 𝗼𝘂𝗿 𝘁𝗲𝗮𝗺? We’d love to hear your thoughts and experiences: 𝘴𝘩𝘢𝘳𝘦 𝘺𝘰𝘶𝘳 𝘵𝘩𝘰𝘶𝘨𝘩𝘵𝘴 𝘢𝘯𝘥 𝘩𝘦𝘭𝘱 𝘴𝘩𝘢𝘱𝘦 𝘰𝘶𝘳 𝘫𝘰𝘶𝘳𝘯𝘦𝘺!

𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗴𝗹𝘆𝗺𝗽𝗵𝗮𝘁𝗶𝗰 𝗳𝗹𝘂𝗶𝗱 𝘁𝗿𝗮𝗻𝘀𝗽𝗼𝗿𝘁 𝗯𝘆 𝗽𝗮𝗻-𝗮𝗱𝗿𝗲𝗻𝗲𝗿𝗴𝗶𝗰 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝗶𝗼𝗻 𝘀𝘂𝗽𝗽𝗿𝗲𝘀𝘀𝗲𝘀 𝗲𝗽𝗶𝗹𝗲𝗽𝘁𝗼𝗴𝗲𝗻𝗲𝘀𝗶𝘀 𝗶𝗻 𝗺𝗮𝗹𝗲 𝗺𝗶𝗰𝗲 Epilepsy, often associated with cognitive and psychological disturbances, can emerge from severe brain insults like status epilepticus (SE) or traumatic injury. SE itself triggers massive release of neuronal glutamate and other neuroactive compounds, setting the stage for chronic seizures and epileptogenesis—a complex, delayed process leading to unprovoked seizures. Despite over 30 years of clinical trials involving medications like phenobarbital and valproic acid, no strategies have effectively prevented post-traumatic epileptogenesis. Emerging research highlights 𝘁𝗵𝗲 𝗿𝗼𝗹𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻'𝘀 𝗴𝗹𝘆𝗺𝗽𝗵𝗮𝘁𝗶𝗰 𝘀𝘆𝘀𝘁𝗲𝗺 - a highly organized network for fluid and solute clearance that works most effectively during sleep. 𝗕𝘆 𝗽𝗿𝗼𝗺𝗼𝘁𝗶𝗻𝗴 𝗴𝗹𝘆𝗺𝗽𝗵𝗮𝘁𝗶𝗰 𝗰𝗹𝗲𝗮𝗿𝗮𝗻𝗰𝗲, 𝘄𝗲 𝗺𝗮𝘆 𝗺𝗼𝗱𝗲𝗿𝗮𝘁𝗲 𝗻𝗲𝘂𝗿𝗼𝗻𝗮𝗹 𝗻𝗲𝘁𝘄𝗼𝗿𝗸 𝗿𝗲𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗽𝗼𝘀𝘁-𝗦𝗘, 𝘄𝗵𝗶𝗰𝗵 𝗵𝗮𝘀 𝗵𝗶𝘀𝘁𝗼𝗿𝗶𝗰𝗮𝗹𝗹𝘆 𝗯𝗲𝗲𝗻 𝗺𝗮𝗿𝗸𝗲𝗱 𝗯𝘆 𝗲𝘅𝗰𝗲𝘀𝘀𝗶𝘃𝗲 𝗲𝘅𝗰𝗶𝘁𝗮𝘁𝗼𝗿𝘆 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆, 𝗺𝗶𝗰𝗿𝗼𝗰𝗶𝗿𝗰𝘂𝗶𝘁 𝗺𝗼𝗱𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀, 𝗮𝗻𝗱 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝗺𝗶𝗰𝗿𝗼𝗲𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀. 𝗧𝗵𝗶𝘀 𝗿𝗲𝗰𝗲𝗻𝘁 𝘀𝘁𝘂𝗱𝘆 𝘂𝘀𝗲𝗱 𝗮 𝗺𝘂𝗿𝗶𝗻𝗲 𝗺𝗼𝗱𝗲𝗹 𝘁𝗼 𝗲𝘅𝗽𝗹𝗼𝗿𝗲 𝘁𝗵𝗶𝘀 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹, testing whether pharmacologically enhancing glymphatic clearance during or post-SE could reduce long-term epilepsy severity, by triggering SE through kainic acid infusion Results were promising: pan-adrenergic receptor inhibition during critical phases improved seizure outcomes, while disruption of glymphatic flow exacerbated chronic epileptic discharges. These findings underline the powerful role of glymphatic transport in modulating epilepsy and point to novel therapeutic avenues that leverage the brain's fluid dynamics. To read more 👉 https://lnkd.in/dKtvkAW5   ****** For the open field test, exploration was video recorded and subsequently analysed via our video tracking software ANY-maze. Many thanks to the authors for the citation

When planning experiments, particularly those involving complex procedures like stereotaxic surgeries, researchers often focus on the primary tools and steps required to achieve their objectives. However, seemingly small tools or accessories, like a Sterilizing Instrument Tray by Stoelting, are easily overlooked despite their potential to streamline processes and ensure better outcomes. Here’s how considering such a tray can be beneficial: 1. 𝗘𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝗜𝗻𝘀𝘁𝗿𝘂𝗺𝗲𝗻𝘁 𝗢𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻   The Sterilizing Instrument Tray (6 x 10 x 1.5 in.) provides a designated, organized space for holding surgical instruments. This is particularly useful during stereotaxic surgeries, where precise tools like probes, forceps, and scalpels need to be sterilized and accessible at all times. 2. 𝗘𝗻𝗵𝗮𝗻𝗰𝗲𝗱 𝗦𝘁𝗲𝗿𝗶𝗹𝗶𝘁𝘆 𝗠𝗮𝗶𝗻𝘁𝗲𝗻𝗮𝗻𝗰𝗲   Stereotaxic surgeries require strict sterility to prevent infections. Using a sterilizing tray helps maintain an aseptic field, as instruments can be sterilized directly in the tray and kept uncontaminated during the procedure. 3. 𝗧𝗶𝗺𝗲-𝗦𝗮𝘃𝗶𝗻𝗴   Instead of individually handling instruments for sterilization or retrieval during the surgery, the tray centralizes these tasks. This reduces time spent searching for or preparing tools, keeping the focus on the delicate surgical procedure. 4. 𝗖𝗼𝗺𝗽𝗮𝗰𝘁 𝗮𝗻𝗱 𝗘𝗮𝘀𝘆 𝘁𝗼 𝗨𝘀𝗲   With its modest size (6 x 10 x 1.5 inches), the tray is small enough to fit into tight surgical setups without cluttering the workspace, making it ideal for lab environments with limited bench space. 5. 𝗗𝘂𝗿𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗮𝗻𝗱 𝗥𝗲𝘂𝘀𝗮𝗯𝗶𝗹𝗶𝘁𝘆   Stoelting's trays are typically made of materials that can withstand repeated autoclaving or chemical sterilization, ensuring long-term use and reliability for repeated procedures. 6. 𝗥𝗲𝗱𝘂𝗰𝗲𝘀 𝗛𝘂𝗺𝗮𝗻 𝗘𝗿𝗿𝗼𝗿   Keeping instruments in a sterilized, organized tray minimizes the chances of contamination or mishandling, which is critical in procedures where precision and hygiene are paramount. 𝗕𝘆 𝗶𝗻𝗰𝗼𝗿𝗽𝗼𝗿𝗮𝘁𝗶𝗻𝗴 𝘀𝘂𝗰𝗵 "𝘁𝗶𝗻𝘆 𝘁𝗼𝗼𝗹𝘀" 𝗶𝗻𝘁𝗼 𝘁𝗵𝗲 𝗽𝗹𝗮𝗻𝗻𝗶𝗻𝗴 𝗽𝗿𝗼𝗰𝗲𝘀𝘀, 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝗿𝘀 𝗰𝗮𝗻 𝗮𝘃𝗼𝗶𝗱 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗱𝗶𝘀𝗿𝘂𝗽𝘁𝗶𝗼𝗻𝘀, 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝘄𝗼𝗿𝗸𝗳𝗹𝗼𝘄 𝗲𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝗰𝘆, 𝗮𝗻𝗱 𝘂𝗹𝘁𝗶𝗺𝗮𝘁𝗲𝗹𝘆 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝘁𝗵𝗲 𝘀𝘂𝗰𝗰𝗲𝘀𝘀 𝗿𝗮𝘁𝗲 𝗼𝗳 𝘁𝗵𝗲𝗶𝗿 𝗲𝘅𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝘁𝘀. While the Sterilizing Instrument Tray might seem minor compared to stereotaxic frames or precision probes, its contribution to maintaining an organized and sterile environment is invaluable. To know more, visit: https://lnkd.in/eQshN7Gt