𝐀 𝐧𝐞𝐰 𝐬𝐭𝐮𝐝𝐲 𝐮𝐧𝐝𝐞𝐫𝐬𝐜𝐨𝐫𝐞𝐬 𝐭𝐡𝐞 𝐧𝐞𝐮𝐫𝐨𝐚𝐜𝐭𝐢𝐯𝐞 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐨𝐟 𝐎𝐩𝐮𝐧𝐭𝐢𝐚 𝐅𝐢𝐜𝐮𝐬-𝐈𝐧𝐝𝐢𝐜𝐚 𝐅𝐫𝐮𝐢𝐭 (𝐎𝐅𝐈𝐅) 𝐢𝐧 𝐭𝐡𝐞 𝐜𝐨𝐧𝐭𝐞𝐱𝐭 𝐨𝐟 𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞-𝐚𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞𝐝 𝐜𝐨𝐠𝐧𝐢𝐭𝐢𝐯𝐞 𝐢𝐦𝐩𝐚𝐢𝐫𝐦𝐞𝐧𝐭, offering insights into its mechanisms and implications for future therapeutic strategies.
Increasing evidence supports the bioactive properties of nutraceuticals in various physiopathological trajectories. The 𝐢𝐧𝐯𝐨𝐥𝐯𝐞𝐦𝐞𝐧𝐭 𝐨𝐟 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐚𝐥 𝐟𝐨𝐨𝐝 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐬 𝐢𝐧 𝐨𝐱𝐲𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲-𝐛𝐚𝐬𝐞𝐝 𝐝𝐢𝐬𝐞𝐚𝐬𝐞𝐬, affecting both peripheral and central systems, is of particular interest.
𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐒𝐲𝐧𝐝𝐫𝐨𝐦𝐞 (𝐌𝐞𝐭𝐒) not only poses serious cardiometabolic risks but also notably 𝐚𝐟𝐟𝐞𝐜𝐭𝐬 𝐜𝐨𝐠𝐧𝐢𝐭𝐢𝐯𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧𝐬, 𝐞𝐬𝐩𝐞𝐜𝐢𝐚𝐥𝐥𝐲 𝐢𝐧 𝐜𝐫𝐢𝐭𝐢𝐜𝐚𝐥 𝐛𝐫𝐚𝐢𝐧 𝐚𝐫𝐞𝐚𝐬 𝐥𝐢𝐤𝐞 𝐭𝐡𝐞 𝐡𝐢𝐩𝐩𝐨𝐜𝐚𝐦𝐩𝐮𝐬 𝐚𝐧𝐝 𝐡𝐲𝐩𝐨𝐭𝐡𝐚𝐥𝐚𝐦𝐮𝐬.
𝘞𝘩𝘪𝘭𝘦 𝑶𝒑𝒖𝒏𝒕𝒊𝒂 𝒇𝒊𝒄𝒖𝒔-𝒊𝒏𝒅𝒊𝒄𝒂 (𝑶𝑭𝑰) 𝘪𝘴 𝘳𝘦𝘯𝘰𝘸𝘯𝘦𝘥 𝘧𝘰𝘳 𝘪𝘵𝘴 𝘩𝘦𝘢𝘭𝘵𝘩 𝘣𝘦𝘯𝘦𝘧𝘪𝘵𝘴, 𝘪𝘵𝘴 𝘧𝘳𝘶𝘪𝘵 (𝘖𝘍𝘐𝘍) 𝘩𝘢𝘴 𝘣𝘦𝘦𝘯 𝘳𝘦𝘭𝘢𝘵𝘪𝘷𝘦𝘭𝘺 𝘶𝘯𝘥𝘦𝘳𝘦𝘹𝘱𝘭𝘰𝘳𝘦𝘥.
🔎 𝐒𝐭𝐮𝐝𝐲 𝐃𝐞𝐬𝐢𝐠𝐧:
🔶 Rats were fed a high-fat diet (HFD) for 8 weeks to induce MetS.
🔶 They received OFIF oral supplementation for 4 weeks.
🔶 Behavioral assessments included open field, burrowing, white-dark box, novelty-suppressed feeding, and object recognition tests.
🔶 Biochemical evaluations covered lipid homeostasis, oxidative stress (central and peripheral), and neurotrophic pathways, with correlations to circulating leptin levels.
🔐 𝐊𝐞𝐲 𝐅𝐢𝐧𝐝𝐢𝐧𝐠𝐬:
🔶 OFIF modulates leptin levels, influencing systemic and brain oxidative stress.
🔶 Higher leptin levels were associated with increased anxiety-like behavior and impaired lipid homeostasis.
🔶 Reduced leptin levels due to OFIF supplementation were linked to improved antioxidant defenses, better declarative memory, and enhanced neurotrophic signaling.
👉 link to full paper: https://lnkd.in/dfEcT_ZJ
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Huge thanks to the researchers for mentioning our behavioural tracking software ANY-maze, which was used in most behavioral protocols to evaluate the animal behavior and cognitive functions.
