Investigating the Molecular and Metabolic Impact of Synthetic Psilocybin versus Natural Mushroom Extract
A recent study conducted by researchers at the The Hebrew University of Jerusalem has revealed groundbreaking findings in the realm of psychiatric therapy. The study suggests that mushroom extract containing psilocybin, a natural psychedelic compound, may offer superior efficacy compared to its chemically synthesized counterpart.
The research focused on synaptic plasticity in mice and found that the mushroom extract exhibited a stronger and more enduring impact on synaptic plasticity, a key factor in addressing psychiatric disorders. This discovery opens up new possibilities for the treatment of conditions such as depression, OCD, and schizophrenia, especially for individuals who do not respond to existing medications.
Moreover, the study highlighted the feasibility of utilizing controlled mushroom cultivation to replicate extracts for medicinal use, overcoming previous challenges associated with natural extracts. These findings signify a promising step forward in the development of innovative, nature-based psychiatric treatments, offering hope to millions worldwide who seek relief from mental health challenges.
Thanks to the authors of this study: Orr Shahar, Botvinnik Alexander,
Amit Shwartz,Elad Lerer,Peretz Golding , Alex Buko ,
Ethan Hamid, Dani Kahn, Miles Guralnick,Karin Blakolmer,
Gilly Wolf, Amit Lotan, Leonard Lerer,
Bernard Lerer &Tzuri Lifschytz
Molecular Psychiatry (2024)Cite this article
Original Research: Open access:
“Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse brain” by Orr Shahar et al.
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