[en] The role of RIS is being directed to evaluate the clinically important or difficult problems and various techniques for improving the signal and reducing the noise are being tested so that the optimal approach to meet the clinical need is achieved. (Author)

[en] This book is part 1 of the proceedings of the symposium. 77 papers are presented in this volume, most of them in English or German. All papers contain abstracts in English, German and French. All papers pertain to the subject areas of the use of radiopharmaceuticals in diagnosis and therapy, most of them in human medicine, some papers deal with animal experiments. Each paper is treated separately for the INIS-Atomindex. (A.N.)

[en] Chromatographically pure and stable anionic species of high charge density cations show higher uptake and give better melanoma images than monoclonal antibodies labeled with the same radionulcides. sup(99m)Tc-labeled antimelanoma antibody filtered for the removal of heavy colloids, hydroxides and oxides of 99m-technetium shows lower uptake in the liver and spleen. (Author)

[en] This presentation shows that hip joint effusion after undisplaced femoral neck fractures may lead to high intracapsular pressure and femoral head ischaemia as demonstrated by scintimetry. Joint aspiration may reverse this ischaemia. (Author)

[en] This book is part 2 of the proceedings of the symposium (part 1 is described in INIS-Atomindex 17/11). 1 lecture, 5 free presentations, 26 free paper sessions, 5 round table sessions and all the discussion remarks for the lectures of pt. 1 and pt. 2 are presented in this volume, most of them in English or German, some in French. All papers contain abstracts in English, German and French. All papers pertain to the subject areas of the use of radiopharmaceuticals in diagnosis and therapy, most of them in human medicine, some papers deal with animal experiments. Each paper is treated separately for this INIS-Atomindex. (A.N.)

[en] Positron tomographs are often characterized by parameters like efficiency, resolution, reconstruction time, number of slices, etc. Due to differences in the method, additional information is needed when comparing conventional PET and TOFPET systems. Reconstruction gain, reduction of random coincidences, and the possibility of measuring cross slices are examined. Properties of two tomographic systems are compared and evaluated. (Author)

[en] Our phase I diagnostic study has shown the anti CEA MoAb FO23C5 to be highly associated with tumour antigens expressed by lung carcinoma and from this its role as a therapeutical tool looks promising. (Author)

[en] The authors propose a metabolic Strontium 85 therapy for painful multiple disseminated metastases with Tc-phosphonate uptake on diagnostic scintigraphy. 65 courses were administered to 59 patients. Results were encouraging with pain relief in more than 7 out of 10 cases. (Author)

[en] Commonly used methods for selecting specific monoclonal antibodies usually do not include parameters relevant for in vivo application, i.e. in immunoscintigraphy. We report on the criteria we used for screening a series of anti-melanoma antibodies. These included determination of immunoreactivity at different levels of radiolabeling. Antigen density was analyzed in various melanoma lines. In addition, the processing of antigen-antibody complexes was followed in metabolically active cells in order to find out whether a given antibody was anchored to the cell surface, internalized or shed. Furthermore, we studied conditions for enzymatic fragmentation of individual monoclonals as well as the immunoreactivity of labeled fragments, as antibody fragments gain increasing importance in immunoscintigraphy. (Author)

[en] A study of ¹²⁵I-TSH pharmacokinetics in mice was performed in order to obtain more information on the peripheral tissues rich in thyrotropin receptors. By comparison with Na ¹²⁵I-biodistribution, it was shown that ¹²⁵I-TSH pharmacokinetics are quite different of that of free radioiodine. After ¹²⁵I-TSH injection, an increased uptake is seen in thyroid, brain, eyes, pancreas and intestine and the pharmacokinetics of the radioactivity in these organs do not follow blood clearance. The results suggest thyrotropin receptors to be present in the above organs. (Author)