[en] Using a first principles approach to electron transport, we calculate the electrical and thermoelectrical transport properties of a series of molecular wires containing benzo-difuran subunits. We demonstrate that the side groups introduce Fano resonances, the energy of which is changing with the electronegativity of selected atoms in it. We also study the relative effect of single, double, or triple bonds along the molecular backbone and find that single bonds yield the highest thermopower, approximately 22 μV/K at room temperature, which is comparable with the highest measured values for single-molecule thermopower reported to date

[en] Cardiac function was studied recording radiocardiographic curves before and after use of intravenous amiodarone HC1, in 40 subjects (20 normal and 20 with hypertension). The recorded radiocardiographic indices were: arm-heart time, mean pulmonary circulation time, mean time of cardiac cycle, stroke volume, cardiac index, systolic volume, systolic index and central blood volume. No alterations were observed in normal subjects. In hypertensive subjects, an alteration in the shape of the curve was noted, with better visualization of the two peaks after the use of the drug. There was statistically significant decrease (p < 0.05) of the following indices: stroke volume, cardiac index, systolic volume, systolic index and central blood volume. In normal subjects, no depressive effect on cardiac muscle was observed. The alterations in the hypertensive subjects were believed to be due to a peripheral action of the drug. (author)

[en] When comparing systematically the radioprotective effects of various 2-acetyl-, -formyl-, -cyano- or -carbethoxy-benzofurans (having several one or no methoxy groups on the homocycle) with these of the corresponding 3-derivatives of 2H-chromene, one always finds chromenes to be more potent than their benzofurannic homologues

[en] We have developed a one-step synthesis of benzofurans from o-iodophenol and various terminal alkynes, by using Pd catalyst supported on nano-sized carbon balls (NCB) under copper- and ligand free conditions. This recyclable catalyst could be reused more than 5 times in the same heteroannulation reaction. The results have demonstrated that diverse 2-substituted benzofurans with tolerant functional groups can be prepared simply and conveniently under these conditions

No abstract available

[en] We disclosed an efficient synthesis of 3-methyl-3-cyanomethyl-2,3-dihydrobenzofuran and 2,3-dihydroindole derivatives via a domino Heck-cyanation process in moderate yields. Palladium-catalyzed domino reactions coupled with suitably designed starting materials allow for rapid establishment of complex molecules. In particular, a palladium-catalyzed consecutive carbon-carbon bond-formations through a Heck-type cascade cyclization has become one of the most popular methods for the synthesis of multiple ring system. The formation of a σ-alkylpalladium intermediate lacking a suitable β-hydrogen syn with respect to the palladium center is essential for the effective cascade bond-formations. In this respect, aryl methallyl ethers and N-methallylanilines were the major subject for the Pd-catalyzed domino reactions. The fate of reactive alkylpalladium intermediate formed by the initial Heck-type cyclization is divided largely into two categories: termination by anion capture process by sodium formate, organotin reagents, arylboronic acid, and cyanide, and termination by C-H activation of either sp"3(C)-H or sp"2(C)-H. However, an efficient palladium-catalyzed domino Heck-cyanation reaction was started very recently although the basic concept dates back to the original paper of Grigg in 1993

[en] Simple and practical synthesis of natural benzofuran derivative eupomatenoid-6 via Horner-Emmons type condensation as the key step is described. The umpolung property of aldehyde derivative, α-aminophosphonate was efficiently employed in this reaction. α-Aminophosphonate of anisaldehyde subjected to Horner-Emmons type condensation with 5-bromo-2-methoxybenzaldehyde to yield the deoxybenzoin, which was further methylated and then underwent tandem demethylation-cyclodehydration to afford the benzofuran scaffold in excellent yield. Finally Suzuki coupling with propenyl boronic acid afforded eupomatenoid-6 with an overall yield of 56.8%

[en] Diversity oriented synthesis of natural 2-arylbenzofuran, moracin F (1) has been carried out from the commercially available starting materials using Sonogashira coupling, Suzuki coupling, neutral Al_2O_3 mediated cyclization, and intramolecular Wittig reaction as key steps.

No abstract available

[en] An efficient and practical preparation of 2-arylbenzo[b]furan molecules including natural egonol, XH-14, ailanthoidol, and unnatural derivatives is demonstrated using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared benzo[b]furans were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that ailanthoidol, XH-14 and three other unnatural derivatives (9-10, 13) inhibited significantly the production of inflammatory mediator nitric oxide without showing cytotoxicity