No abstract available

[en] In the recoil system ¹¹C+C₆H₆ the two primary products are ¹¹CH and ¹¹C₇H₆. These intermediates are formed by ¹¹C-insertion in a C-H bond and by π-addition, respectively. The - excited - carbenes ¹¹C₇H₆ are produced with a probability of about 70%, and are to a great extent responsible for the formation of polymers. Conspicuously, polymers heavier than tetramers were not observed. Secondary intermediates ¹¹C₇H₇ and ¹¹C₁₂H₁₁ react with radicals produced in the spur of the ¹¹C recoil particle to produce the trimers and tetramers. Thermalized carbenes ¹¹C₇H₆ give rise to dimers. (orig.)

[en] Highlights: • A radio-analytical method was validated for the [¹¹C]GSK1482160 radiopharmaceutical. • The method proved to be robust and unaffected by small changes in the chromatographic conditions. • The [¹¹C]GSK1482160 radiopharmaceutical exhibits high radiochemical stability. • [¹¹C]GSK1482160 radiopharmaceutical can be delivered in accordance with USP requirements. • The P2X7-receptor-targeted [¹¹C]GSK1482160 meets release criteria for human use. - Abstract: A radio-analytical RP-HPLC method was developed and validated to support production of the P2X7-receptor-targeted [¹¹C]GSK1482160 radiopharmaceutical. Method validation included characterization of retention times, peak shapes, linearity, accuracy, precision, selectivity, limits of detection and quantitation (UV signal), radiochemical stability, as well as analytical method range and robustness. The validated radio-HPLC method is suitable for the definition of [¹¹C]GSK1482160 radiochemical identity, radiochemical purity, as well as molar activity, and is being employed in support of human studies with [¹¹C]GSK1482160.

[en] The LICORNE neutron source is a new device at the ALTO facility. Its use of inverse kinematics makes the production of naturally focused neutron beams possible with an energy range of 0.5 to 4 MeV. This is perfect for any studies concerning fast neutron induced reaction based on detection setup that require to be placed in a compact geometry - such as Ge based γ detection setup. In this paper, neutron production with LICORNE is described. The development of a gas cell target and the extension of the energy range up to 7 MeV with the p(¹¹B,n)¹¹C are presented. An overview of the major research fields studied with LICORNE is given and two types of experiment are presented. The first one dedicated to prompt fission γ-ray emission in fission, as a function of incident neutron energy, is described. Some preliminary results are shown. The second, in the context of the MINORCA campaign, is detailed. The most recent outcomes in the data analysis process are also presented. (authors)

No abstract available

[en] Short communication

[en] Introduction: The increased demand for high specific radioactivity neuroreceptor ligands for positron emission tomography (PET) requires the production of high specific radioactivity carbon-11 in high yields. We have attempted to address this issue with the development of a new quartz-lined aluminium target for the production of [¹¹C]methane or [¹¹C]carbon dioxide. Methods: The new target has been tested with respect to yields of [¹¹C]methane and [¹¹C]carbon dioxide, and the effect of the quartz liner has been evaluated. The specific radioactivities of a large number of radiopharmaceuticals produced using this target have also been measured. Results: The described target produces [¹¹C]-labelled gases in excellent yields, and losses of radioactivity in the target on production of [¹¹C]methane have been reduced significantly by the use of a quartz liner. Radiopharmaceuticals with specific radioactivities up to 9000 GBq/μmol at end of bombardment (EOB) (243 Ci/μmol) have been produced using this target. Conclusions: We have developed a reliable, high-yielding carbon-11 gas target which is now routinely used in our department for the production of high specific activity radiopharmaceuticals.

[en] The synthesis of benzaldehyde, anisaldehyde,4-tert-butoxybenzaldehyde, veratraldehyde, piperonal and phenylacetaldehyde labelled with ¹¹C(tsub(1/2) similar to 20.3 min) in the 1-position is reported. (author)

[en] An automated system was developed for the routine preparation of carbon-11 (¹¹C) labeled radiophar-maceuticals, which consisted of three major parts including [¹¹C]methylation of the precusor with [¹¹C] iodomethane ([¹¹C]CH₃I), purification of the desired product and formulation of the final ¹¹C labeled radiopharmaceutical. The whole system included seven three-way slider valves, eleven solenoid valves, four pneumatic cylinders, a HPLC (High Performance Liquid Chromatography) system and a rotary evaporator. Using this system, we investigated the radiochemical synthesis of L-[methyl-¹¹C]methionine, which is the most widely used amino acid in tumor PET (Positron Emission Tomography) studies. The overall operation took 30-35 min including the production of [¹¹C]CH₃I (10.5 min) and decay-corrected radiochemical yield was 25%. The automated system we described herein can be widely utilized for the preparation of many ¹¹C labeled radiopharmaceuticals and has been shown to be efficient, reliable and easy to operate

[en] Treatment of Parkinson’s disease with dopaminergic preparation has besides the positive effects on the course of the disease many side effects. The most prominent adverse event of long term administration of levodopa and dopamine receptor agonist are motor fluctuation, levodopa induced dyskinesias and psychotic side effects. Authors in the article describe the pathophysiology of motor fluctuation and levodopa induced dyskinesias in the patients with Parkinson’s disease treated by dopaminergic medication. (author)