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AbstractAbstract
[en] Chronic administration of Dianabol did not prevent the radiation-induced changes of oxidative phosphorylation in rat liver mitochondria. Irradiation of rats with X-rays, in a dose of 600 R for the whole body, causes damage of oxidative phosphorylation in rat liver mitochondria. Progressive reduction of oxygen consumption, decrease of high-energy bond formation and a drop of the P/O coefficient were observed in irradiated animals. The presumable role of the postirradiation damage of oxidative phosphorylation and the effects of radioprotective compounds on this process are discussed. (orig.)
[de]
Eine Daueranwendung von Dianabol konnte die strahlenbedingten Veraenderungen der oxidativen Phosphorylierung in Rattenlebermitochondrien nicht verhindern. Die Ganzkoerperbestrahlung von Ratten mit einer Roentgendosis von 600 R beeintraechtigt die oxidative Phosphorylierung in Rattenlebermitochondrien. Bei den bestrahlten Tieren wurde festgestellt, dass der Sauerstoffverbrauch immer mehr abnimmt, dass die Entstehung von energiereichen Bindungen nachlaesst und der P/O-Koeffizient absinkt. Die moeglichen Auswirkungen des Schadens nach Bestrahlung, der sich bei der oxidativen Phosphorylierung zeigt, und die Beeinflussung dieses Vorgangs durch Radioprotektoren werden diskutiert. (orig.)Primary Subject
Record Type
Journal Article
Journal
Strahlentherapie; v. 155(10); p. 726-730
Country of publication
ANDROGENS, ANDROSTANES, ANIMALS, BIOLOGICAL EFFECTS, BODY, CELL CONSTITUENTS, CHEMICAL REACTIONS, DIGESTIVE SYSTEM, DRUGS, ELECTROMAGNETIC RADIATION, EXTERNAL IRRADIATION, GLANDS, HORMONES, HYDROXY COMPOUNDS, IONIZING RADIATIONS, IRRADIATION, KETONES, MAMMALS, ORGANIC COMPOUNDS, ORGANOIDS, ORGANS, RADIATION EFFECTS, RADIATIONS, RADIOPROTECTIVE SUBSTANCES, RESPONSE MODIFYING FACTORS, RODENTS, STEROID HORMONES, STEROIDS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
AbstractAbstract
No abstract available
Original Title
Vliyanie dianabola na postradiatsionnye narusheniya glikogeneza v pecheni krysy
Primary Subject
Source
Short note; for English translation see the journal Radiobiology (USA).
Record Type
Journal Article
Journal
Radiobiologiya; ISSN 0033-8192; 
; v. 19(5); p. 747-750
; v. 19(5); p. 747-750
Country of publication
ANDROGENS, ANDROSTANES, ANIMALS, BIOLOGICAL EFFECTS, BIOLOGICAL RADIATION EFFECTS, BODY, CARBOHYDRATES, DIGESTIVE SYSTEM, DRUGS, ELECTROMAGNETIC RADIATION, GLANDS, HORMONES, HYDROXY COMPOUNDS, IONIZING RADIATIONS, KETONES, MAMMALS, ORGANIC COMPOUNDS, ORGANS, POLYSACCHARIDES, RADIATION EFFECTS, RADIATIONS, RADIOPROTECTIVE SUBSTANCES, RESPONSE MODIFYING FACTORS, RODENTS, SACCHARIDES, STEROID HORMONES, STEROIDS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
AbstractAbstract
[en] Chronic administration of Dianabol did not prevent the radiation-induced changes of oxidative phosphorylation in rat liver mitochondria. Irradiation of rats with X-rays, in a dose of 600 R for the whole body, causes damage of oxidative phosphorylation in rat liver mitochondria. Progressive reduction of oxygen consumption, decrease of high-energy bond formation and a drop of the P/O coefficient were observed in irradiated animals. The presumable role of the postirradiation damage of oxidative phosphorylation and the effects of radioprotective compounds on this process are discussed. (orig.)
[de]
Eine Daueranwendung von Dianabol konnte die strahlenbedingten Veraenderungen der oxidativen Phosphorylierung in Rattenlebermitochondrien nicht verhindern. Die Ganzkoerperbestrahlung von Ratten mit einer Roentgendosis von 600 R beeintraechtigt die oxidative Phosphorylierung in Rattenlebermitochondrien. Bei den bestrahlten Tieren wurde festgestellt, dass der Sauerstoffverbrauch immer mehr abnimmt, dass die Entstehung von energiereichen Bindungen nachlaesst und der P/O-Koeffizient absinkt. Die moeglichen Auswirkungen des Schadens nach Bestrahlung, der sich bei der oxidativen Phosphorylierung zeigt, und die Beeinflussung dieses Vorgangs durch Radioprotektoren werden diskutiert. (orig.)Primary Subject
Record Type
Journal Article
Journal
Strahlentherapie; v. 155(10); p. 726-730
Country of publication
ANDROGENS, ANDROSTANES, ANIMALS, BIOLOGICAL EFFECTS, BODY, CELL CONSTITUENTS, CHEMICAL REACTIONS, DIGESTIVE SYSTEM, DRUGS, ELECTROMAGNETIC RADIATION, EXTERNAL IRRADIATION, GLANDS, HORMONES, HYDROXY COMPOUNDS, IONIZING RADIATIONS, IRRADIATION, KETONES, MAMMALS, ORGANIC COMPOUNDS, ORGANOIDS, ORGANS, RADIATION EFFECTS, RADIATIONS, RADIOPROTECTIVE SUBSTANCES, RESPONSE MODIFYING FACTORS, RODENTS, STEROID HORMONES, STEROIDS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
AbstractAbstract
[en] Dianabol administered p.o. in the dose of 1.0 mg/kg during 10 days before irradiation had no radioprotective effect in the fractionated irradiation (5 x 150 R). Distinct radioprotection, however, was exerted by the DMSO, Trasylol and Trichlorfon (30 mg/kg) administration. (orig.)
[de]
Dianabol, peroral in einer Dosis von 1,0 mg/kg zehn Tage lang vor Bestrahlung appliziert, hatte keine Strahlenschutzwirkung bei fraktionierter Bestrahlung (5 x 150 R). Eine deutliche Strahlenschutzwirkung wurde jedoch durch Gaben von DMSO, Trasylol und Trichlorfon (30 mg/kg) hervorgerufen. (orig.)Primary Subject
Source
2 figs.; 1 tab.; 18 refs.
Record Type
Journal Article
Journal
Strahlentherapie; v. 150(1); p. 91-96
Country of publication
ANDROGENS, ANDROSTANES, ANIMALS, BIOLOGICAL EFFECTS, DRUGS, ELECTROMAGNETIC RADIATION, HORMONES, HYDROXY COMPOUNDS, IONIZING RADIATIONS, IRRADIATION, KETONES, MAMMALS, ORGANIC COMPOUNDS, ORGANIC SULFUR COMPOUNDS, RADIATION EFFECTS, RADIATIONS, RESPONSE MODIFYING FACTORS, RODENTS, STEROID HORMONES, STEROIDS, SULFOXIDES, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
AbstractAbstract
No abstract available
Original Title
Vliyanie dianabola na postradiatsionnye narusheniya glikoliza pecheni krys
Primary Subject
Source
Short note; for English translation see the journal Radiobiology (Translation) (USA).
Record Type
Journal Article
Journal
Radiobiologiya; ISSN 0033-8192; ; v. 21(1); p. 120-122
; v. 21(1); p. 120-122
Country of publication
ANDROGENS, ANDROSTANES, ANIMALS, BIOLOGICAL EFFECTS, BIOLOGICAL RADIATION EFFECTS, BODY, CHEMICAL REACTIONS, DECOMPOSITION, DIGESTIVE SYSTEM, DRUGS, ELECTROMAGNETIC RADIATION, EXTERNAL IRRADIATION, GLANDS, HORMONES, HYDROXY COMPOUNDS, IONIZING RADIATIONS, IRRADIATION, KETONES, MAMMALS, ORGANIC COMPOUNDS, ORGANS, RADIATION EFFECTS, RADIATIONS, RADIOPROTECTIVE SUBSTANCES, RESPONSE MODIFYING FACTORS, RODENTS, STEROID HORMONES, STEROIDS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
AbstractAbstract
[en] Studies were made on the radioprotective effect of Dianabol using two different modes of irradiation. It was found, that Dianabol did not have any effect on the dynamics of the survival of the rats irradiated daily with the dose of 75 and 150 R (up to the time of their death). By limited fractionated irradiation (5 x 150 R) Dianabol had a slight protective effect in the survival estimation. This was found to increase by using Trasylol. (author)
Original Title
Badania nad radiochronnym dzialaniem dianabolu i trasylolu przy napromienieniu frakczjonowanym szczurow
Primary Subject
Record Type
Journal Article
Journal
Postepy Fizyki Medycznej; v. 9(4); p. 185-191
Country of publication
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
Milivoevich, K.; Stoyanovich, D.
Second radiobiological conference of socialist countries, 9-14 October 1978, Varna, Bulgaria1978
Second radiobiological conference of socialist countries, 9-14 October 1978, Varna, Bulgaria1978
AbstractAbstract
No abstract available
Original Title
Izuchenie ehffekta terapii ostroj luchevoj bolezni primeneniem vitaminov i gormonov u opytnykh zhivotnykh
Primary Subject
Source
Meditsinska Akademiya, Sofia (Bulgaria). Nauchen Inst. po Rentgenologiya i Radiobiologiya; p. 193-194; Oct 1978; p. 193-194; 2. Radiobiological conference of socialist countries; Varna, Bulgaria; 9 - 14 Oct 1978; Published in summary form only.
Record Type
Miscellaneous
Literature Type
Conference
Report Number
Country of publication
ANDROGENS, ANDROSTANES, ANIMAL CELLS, ANIMALS, AROMATICS, AZINES, BIOLOGICAL EFFECTS, BIOLOGICAL MATERIALS, BIOLOGICAL RADIATION EFFECTS, BLOOD, BLOOD CELLS, BODY FLUIDS, CARBOXYLIC ACIDS, CONNECTIVE TISSUE CELLS, DISEASES, DRUGS, ERYTHROCYTES, HETEROCYCLIC ACIDS, HETEROCYCLIC COMPOUNDS, HYDROXY COMPOUNDS, INJURIES, IRRADIATION, KETONES, MAMMALS, MEDICINE, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANIC OXYGEN COMPOUNDS, PIGMENTS, PORPHYRINS, PROTEINS, PYRIDINES, QUINONES, RADIATION EFFECTS, RADIOPROTECTIVE SUBSTANCES, RESPONSE MODIFYING FACTORS, RODENTS, SOMATIC CELLS, STEROID HORMONES, STEROIDS, THERAPY, VERTEBRATES, VITAMIN B GROUP, VITAMINS
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
AbstractAbstract
No abstract available
Primary Subject
Source
4 figs.; 27 refs.
Record Type
Journal Article
Journal
Strahlentherapie; v. 148(2); p. 168-172
Country of publication
ANDROSTANES, ANIMALS, BODY, CARBOXYLIC ACIDS, CHEMISTRY, DICARBOXYLIC ACIDS, DIGESTIVE SYSTEM, DRUGS, ELECTROMAGNETIC RADIATION, ENZYMES, GLANDS, HORMONES, HYDROXY ACIDS, HYDROXY COMPOUNDS, IONIZING RADIATIONS, KETO ACIDS, KETONES, MAMMALS, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANS, OXIDASES, OXIDOREDUCTASES, RADIATIONS, RESPONSE MODIFYING FACTORS, RODENTS, STEROID HORMONES, STEROIDS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue
Siegel, G.; Tapp, E.; Haehn, J.; Hannig, H.; Dlaske, R.
Staatliches Amt fuer Atomsicherheit und Strahlenschutz, Berlin (German Democratic Republic)1976
Staatliches Amt fuer Atomsicherheit und Strahlenschutz, Berlin (German Democratic Republic)1976
AbstractAbstract
[en] Papers published in 1974 in the field of chemical protection against ionizing radiation are reviewed. Protection studies in vitro and in vivo, the biochemical, pharmacological and toxic effects, the mechanisms of protection of radioprotective agents and the trends in this field of research are described. (author)
Original Title
Stand und Entwicklungstendenzen des chemischen Strahlenschutzes
Primary Subject
Secondary Subject
Source
Mar 1976; 76 p; 289 refs.
Record Type
Report
Report Number
Country of publication
AET, ANOXIA, ASCORBIC ACID, ATP, BIBLIOGRAPHIES, BIOCHEMISTRY, BIOFLAVONOIDS, CYSTAMINE, CYSTEINE, DIANABOL, DISULFIDES, DITHIOLS, DMSO, GLUTATHIONE, IN VITRO, IN VIVO, INDOLES, MEA, MEXAMINE, NUCLEOTIDES, PAPP, PHARMACOLOGY, RADIATION PROTECTION, RADIOPROTECTIVE SUBSTANCES, RADIOSENSITIZERS, REVIEWS, SEROTONIN, THIOLS, THIOPHOSPHORIC ACID ESTERS, THIOSULFATES, THIOUREAS, TOXICITY, TRYPTAMINES, VITAMIN E
AMINES, AMINO ACIDS, ANDROGENS, ANDROSTANES, AZOLES, CARBONIC ACID DERIVATIVES, CARBOXYLIC ACIDS, CHEMISTRY, DOCUMENT TYPES, DRUGS, ESTERS, ETHERS, HETEROCYCLIC COMPOUNDS, HORMONES, HYDROXY COMPOUNDS, KETONES, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANIC OXYGEN COMPOUNDS, ORGANIC SULFUR COMPOUNDS, PEPTIDES, POLYPEPTIDES, PROTEINS, PYRROLES, REAGENTS, RESPONSE MODIFYING FACTORS, STEROID HORMONES, STEROIDS, SULFOXIDES, SYMPATHOMIMETICS, VITAMINS
Reference NumberReference Number
Related RecordRelated Record
INIS VolumeINIS Volume
INIS IssueINIS Issue
Siegel, G.; Tapp, E.; Haehn, J.; Hannig, H.; Dlaske, R.; Martinek, K.
Staatliches Amt fuer Atomsicherheit und Strahlenschutz, Berlin (German Democratic Republic)1977
Staatliches Amt fuer Atomsicherheit und Strahlenschutz, Berlin (German Democratic Republic)1977
AbstractAbstract
[en] Papers published in 1975 in the field of chemical protection against ionizing radiation are reviewed. Protection studies in vitro and in vivo, the biochemical, pharmacological and toxic effects, the mechanisms of protection of radioprotective agents and the trends in this field of research are described. (author)
Original Title
Stand und Entwicklungstendenzen des chemischen Strahlenschutzes
Primary Subject
Secondary Subject
Source
Jan 1977; 80 p
Record Type
Report
Report Number
Country of publication
AET, ASCORBIC ACID, ATP, BENZIMIDAZOLES, BENZOTHIAZOLES, BIOCHEMISTRY, BIOFLAVONOIDS, CYSTAMINE, CYSTAPHOS, CYSTEINE, DIANABOL, DISULFIDES, DITHIOLS, DMSO, GAMMA RADIATION, GLUTATHIONE, IN VITRO, IN VIVO, INDAZOLES, INDOLES, MEA, MEG, NEUTRONS, NUCLEOTIDES, PAPP, PENICILLAMINE, PHARMACOLOGY, PURINES, PYRIMIDINES, RADIATION PROTECTION, RADIOPROTECTIVE SUBSTANCES, RESERPINE, REVIEWS, TETRAZOLES, THIOLS, THIOPHOSPHORIC ACID ESTERS, THIOUREAS, TOXICITY, TRYPTAMINES, VITAMIN E, X RADIATION
ALKALOIDS, AMINES, AMINO ACIDS, ANDROGENS, ANDROSTANES, AZINES, AZOLES, BARYONS, CARBONIC ACID DERIVATIVES, CARBOXYLIC ACIDS, CHELATING AGENTS, CHEMISTRY, DOCUMENT TYPES, DRUGS, ELECTROMAGNETIC RADIATION, ELEMENTARY PARTICLES, ESTERS, FERMIONS, HADRONS, HETEROCYCLIC COMPOUNDS, HORMONES, HYDROXY COMPOUNDS, IMIDAZOLES, IONIZING RADIATIONS, KETONES, NUCLEONS, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANIC SULFUR COMPOUNDS, PEPTIDES, POLYPEPTIDES, PROTEINS, PSYCHOTROPIC DRUGS, PYRAZOLES, PYRROLES, RADIATIONS, REAGENTS, RESPONSE MODIFYING FACTORS, STEROID HORMONES, STEROIDS, SULFOXIDES, THIAZOLES, TRANQUILIZERS, VITAMINS
Reference NumberReference Number
Related RecordRelated Record
INIS VolumeINIS Volume
INIS IssueINIS Issue