No abstract available

[en] The author gives a survey of the progress made on radioimmunodetection. Antibodies may now be more readily used in scintigraphy as a result of the development of labeling methods that apply more suitable radionuclides without significant loss of the antigen-binding activity. Antibodies to tumor-specific or tumor-associated antigens can now be produced in large quantities by monoclonal antibody technology

[en] Anti-alpha-fetoprotein (AFP) radioimmunodetection was performed in response to clinical requests in 16 patients. In two patients, assessment of a known tumour was required; the anti-AFP scans were accurate and provided useful clinical information in both cases. In the remaining 14 patients the request was for localisation of suspected recurrent tumour. Accurate information was provided in four of these patients. In this latter group, various conventional methods of investigation had failed to disclose the site of recurrence. However, of a total of 21 sites reported as positive in these 14 patients, eight proved to be false positives. Two false negative results also occurred in this group and nine could not be evaluated. Although occasionally patients were usefully scanned, improvements are necessary before consistently reliable information can be obtained using this technique. (author)

[en] We briefly review the utilisation of tumor radioimmunodetection, its present limitations and some areas under development. We also discuss its application in immuno-lymphoscintigraphy which could increase the accuracy of staging of primary breast cancer

[en] Objective: To establish the reference intervals of serum TRAb level among healthy population in some areas of Shanghai. Methods: Serum TRAb level was detected with electrochemiluminescence immunoassay in 1468 health subjects. SPSS 19.0 was used to obtain mean, median, and percentiles of upper and lower limits of reference interval for all subjects. Results: In 1468 health subjects, the level of TRAb showed a skewed distribution, and the reference intervals was established by percentile method (95%). There was no statistical significance among different ages and genders (P > 0.05). The uniform reference intervals could be established (0.30-0.82 IU/L). Conclusion: The reference interval of serum TRAb level is established for healthy population in some areas of Shanghai. (authors)

[en] Disseminated malignant melanoma is an aggressive tumor. Multiple therapeutic strategies have been attempted, unfortunately, the response rate of disseminated melanoma to therapy is invariably poor, independent of modality of treatment. The authors are evaluating a new diagnostic and therapeutic strategy consisting of the use of radiolabeled monoclonal antibody (MoAb) and its fragments directed against p97, a melanoma-associated antigen, as a vehicle for localization and selective delivery of high-dose radiation. (Auth.)

[en] Eighteen chapters review the use of monoclonal antibodies for cancer detection and therapy. Eleven chapters covering various different types of antibodies used for a range of cancers, developments in antibody imaging in the radioimmunodetection of tumours and the use of radiolabelled antibodies in cancer radiotherapy were selected and indexed separately. (UK)

[en] A brief article describes the use of immunoscintigraphy in the diagnosis of tumour recurrence. Scintigraphic methodology is considered including the choice of antibody, radionuclide and detection method. The clinical value, limitations and future prospects for immunoscintigraphy are discussed. (UK)

[en] Imaging tissues rich in B lymphocytes in man using a radiolabeled monoclonal anti-B cell antibody would be extremely useful in the clinical staging of non-Hodgkins lymphomas. Studies were done in rhesus monkeys using radiolabeled monoclonal anti-B1 antibody to determine the feasibility of such an approach. Immunohistologic studies demonstrated that infused monoclonal anti-B1 binds in vivo with specificity to B cells in lymph nodes and spleen. The kinetics of clearance of ¹³¹I-labeled anti-B1 were determined. The B lymphocyte-rich spleen could be readily visualized by gamma camera scanning without significant background and without the need for image intensification or blood background subtraction techniques. These data support the feasibility of using anti-B1 for staging B cell lymphomas in man. (author)

[en] Radioimmunoscintigraphy is a diagnostic method which uses labelled monoclonal antibodies for the visualization of tumorous foci. It is a nuclear medicine method developing rapidly. Fundamental studies on the bioavailability of antibodies in animal models are listed, and contemporary clinical studies on the diagnostic use of commercial monoclonal antibodies are reviewed. (author). 4 figs., 1 tab., 26 refs