[en] A microprocessor-based device has been developed to virtually eliminate the effects of nonlinearity and nonuniformity in radioisotope camera signals. Imperfections in the X and Y spatial signals or the Z energy signal can otherwise lead to spatial distortion, non-constant sensitivity, and flood non-uniformity in the resulting images. A device operates in real time on each event from the camera, and is fast enough to allow counting rates up to 120,000 per second without loss. Non-linearities in the X and Y signals are eliminated by carrying out an on-the-fly translation to corrected U and V position coordinates. The translation table is constructed based on calibration images of a parallel line phantom. Possible variations in the Z signal are accomodated by also including in the table a 64 x 64 array of spatially-depedent energy windows. These data are automatically generated based on a calibration flood image. The device operates in conjunction with an MDS Modumed Data System, and has been demonstrated using three different radioisotopes cameras. In all cases, significant improvement in image linearity and uniformity has been observed