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AbstractAbstract
[en] The labelling of uracil (C4H4N2O2) with radioiodine (131I) have been carried out by means of reaction with iodomonochloride (131I). The analysis of the resulting iodinated compound was done using Whatman I paper chromatography and Silica Gel 60 F254 thin-layer chromatography with a mixture of n-butanol-glacial acetic acid-water (75:30:50, v/v) as the eluting solvent. The result of UV spectrophotometric analysis strengthened the supposition that the labelling mechanism is an electrophilic substitution which gives 5-radioiodouracil as the resulting iodinated compound. The yield with the best labelling conditions was more than 97% so that purification of the iodinated compound was not necessary. It was observed that the final products were radiochemically stable after 8 days under ordinary storage conditions. (author). 8 refs
Original Title
Radioiodinasi uracil melalui reaksi dengan iodomonokloroda (131I)
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Journal Article
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ALCOHOLS, ANTIMETABOLITES, AZINES, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CARBOXYLIC ACIDS, CHEMICAL REACTIONS, CHLORIDES, CHLORINE COMPOUNDS, DAYS LIVING RADIOISOTOPES, DRUGS, HALIDES, HALOGEN COMPOUNDS, HALOGENATION, HETEROCYCLIC COMPOUNDS, HYDROXY COMPOUNDS, INTERMEDIATE MASS NUCLEI, IODINE COMPOUNDS, IODINE ISOTOPES, ISOTOPES, MONOCARBOXYLIC ACIDS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC IODINE COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, PYRIMIDINES, RADIOISOTOPES, SEPARATION PROCESSES, SYNTHESIS
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