[en] Many diagnostic imaging procedures such as nuclear medicine, ultrasound, and computerized tomography (CT) are available to the clinician for the evaluation of liver diseases. No single modality has emerged as the best method for detection of liver pathology. Radionuclide liver-spleen imaging remains an attractive screening procedure. Until recently, only planar radionuclide imaging techniques were available. The introduction of computers and cameras equipped with rotating heads capable of performing SPECT has added new dimension to the diagnostic value in detection of liver pathology. This report describes the authors experience with a such a system and presents three illustrative cases. Two of them had been confirmed surgically, whereas the third had been confirmed histologically by needle biopsy