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AbstractAbstract
[en] The aim of the present investigation was the radioisotopic study of the pharmokinetics of the new, previously synthesized (by the authors) antiviral preparation arbidole, which was authorized for medical use as a prophylactic agent and for treating influenza. Moreover, the investigations have shown that arbidole has an antimetastatic action in experiments on animals. The method of synthesizing arbidole 14C labeled at two atoms is discussed. It is concluded from the results that the maximal levels of radioactivity in the organs and tissues of mice is recorded during the first hour after peroral administration of 14C-arbidole. According to the degree of accumulation of the radioactivity, the organs and tissues can be arranged in the following (decreasing) order: liver, blood plasma, kidneys, lungs, spleen, thymus, adrenal glands, lymphatic glands, thyroid glands, hypophysis. Up to 90% of the introduced radioactivity is eliminated from the organs during the first day. 4 refs., 2 tabs
Primary Subject
Source
Translated from Khimiko-farmatsevticheskii Zhurnal; 27: No. 2, 11-13(Feb 1993).
Record Type
Journal Article
Literature Type
Numerical Data; Translation
Journal
Country of publication
ANIMALS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CARBON ISOTOPES, CARBOXYLIC ACID SALTS, DATA, DISTRIBUTION, DRUGS, EVEN-EVEN NUCLEI, INFORMATION, ISOTOPE APPLICATIONS, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MAMMALS, MATERIALS, NUCLEI, NUMERICAL DATA, RADIOACTIVE MATERIALS, RADIOISOTOPES, RODENTS, VERTEBRATES, YEARS LIVING RADIOISOTOPES
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