[en] We report here the study of the brain phospholipid content of normal and myelin deficient (md) rats, which develop a physiological impairment at about 15-20 days, and die at 20-25 days of age. The aim is to gain insights into the lipid composition of developing brain, and also to reveal of there exist some early event in the phospholipid metabolism that produces a pathological condition similar to the formation of demyelination plaques in multiple sclerosis. ³¹ P NMR allows one to detect phospholipids selectively out of a complex lipid mixture in crude extracts. Two-dimensional (2D) ³¹ P-^1H NMR with isotropic proton mixing seems to be a superior technique for assignment of phospholipid ³¹ P resonances. (author)