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AbstractAbstract
[en] Full text: The recommended method for the preparation of 99mTc-MIBI and 99mTc-MAG3 requires that they be heated in a boiling water bath for 10 minutes, after reconstitution with sodium pertechnetate. This method is both inconvenient and time consuming. A more rapid and convenient method for the preparation of these radiopharmaceuticals employs a conventional microwave oven. However, a serious limitation of this method is the hazard associated with an explosion of a vessel containing a radioactive substance. Traditionally, mixtures that can potentially explode are contained in a device called a 'bomb'. We have developed a method, utilising such a device, that allows us to rapidly and safely prepare 99mTc-MIBI and 99mTc-MAG3 using a microwave oven. This device is used in our department on a daily basis. Since using the teflon bomb, there has been one incidence of an explosion, which was successfully contained within the bomb. There was no statistically significant difference between the radiochemical purity (RCP) of the microwave prepared samples and those obtained using the recommended method. In conclusion, 99mTc-MIBI and 99mTc-MAG3 can be safely prepared and quality controlled in under ten minutes using a microwave oven and our teflon bomb. The average RCP for 99mTc-MIBI and 99mTc-MAG3 prepared using a microwave oven were 97.0+2.0% (n=19) and 99.8+0.2 (n=7) respectively
Source
Annual scientific meeting of the Australian and New Zealand Society of Nuclear Medicine; Melbourne, VIC (Australia); 4-8 Apr 1998
Record Type
Journal Article
Literature Type
Conference
Journal
Country of publication
BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CARBONIC ACID DERIVATIVES, CHEMISTRY, CONTROL, DRUGS, ELECTRONIC EQUIPMENT, EQUIPMENT, HEATING, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, MATERIALS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC FLUORINE COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC POLYMERS, PETROLEUM PRODUCTS, PLASTICS, POLYETHYLENES, POLYMERS, POLYOLEFINS, RADIOACTIVE MATERIALS, RADIOISOTOPES, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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