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[en] The effect of Paclitaxel (PAC), Epirubicin (EPR) and Tamoxifen (TAM) on ''3H-thymidine labelling index (''3H-TdR LI) of Ehrlich ascites tumor cells (EAT) was investigated in cultured. In the present study, an estrogen receptor positive ER(+) hyper diploid cell lines were studied. We used optimum doses of PAC, EPR and TAM (12 mg/ml, 12 mg/ml and 2 mg/ml, respectively). Cells were treated with these doses for 0, 4, 8, 16 and 32 hours. At the end of these periods, both control and treated cells were labelled for 5 mCi/ml 3H-thymidine for 30 minutes. The results showed that inhibition of DNA synthesis in cultured EAT cells were increased in the combined treatment of two drugs when compared to the treatment of a single drug (p<0.01). In the treatment of three drugs, however, this effect reached a maximum (p<0.001). As a result, PAC+EPR+TAM treatment's had a maximum synergistic effect at 4 hours treatment
Source
Turkish Atomic Energy Authority, Ankara (Turkey); International Atomic Energy Agency, Vienna (Austria); OECD/Nuclear Energy Agency, Paris (France); State Planning Organization, Ankara (Turkey); Ege University, Izmir (Turkey); Institute of Nuclear Physics of Uzbekistan Academy of Science, Taskent (Uzbekistan); National Acedemy of Science of Kyrgyzstan, Biskek (Kyrgyzstan); Institute of Nuclear Physics of National Nuclear Center of Kazakhstan, Almaty (Kazakhstan); Academy of Science of Azerbaijan, Baku (Azerbaijan); 642 p; ISBN 975-19-2768-4; 
; 2001; p. 492-496; 1. Eurasia Conference on Nuclear Science and Its Application; 1. Avrasya Nuekleer Bilimler ve Uygulamalari Konferansi; Izmir (Turkey); 23-27 Oct 2000; Available from Turkish Atomic Energy Authority, Ankara (Turkey)
; 2001; p. 492-496; 1. Eurasia Conference on Nuclear Science and Its Application; 1. Avrasya Nuekleer Bilimler ve Uygulamalari Konferansi; Izmir (Turkey); 23-27 Oct 2000; Available from Turkish Atomic Energy Authority, Ankara (Turkey)