[en] To investigate the characteristics of expression and distribution of 5 subtypes of somatostatin receptors (SSTR1-5) in lung cancer. With (α-³⁵S) dATP labeled oligonucleotide of the 5 SSTR subtypes as probe, using in situ hybridization, patterns of mRNA expression were detected of lung cancer tissues of 2 cases that fell in varied pathologic types. Additionally, Leica was employed to semi-quantitatively analyze density of the expression. Patterns of SSTR1∼5 expression in lung cancer were as follows: SSTR2 expression was dominant in SCLC while in such NSCLC as adenous and squamous SSTR1 expression was stronger than that of the other 4 subtypes; In density of SSTR1∼ 5 expression in lung cancer, NSCLC was higher than SCLC (p<0.01). Even though patterns and density of expression of SSTR subtypes in lung cancer showed heterogeneity in pathohistologic types, as in SCLC, in NSCLC SSTR expression occurred as well. Therefore, it has positive prospects for somatostatin analog-oriented agents to be used in treatment of both of the lung cancers