[en] Full text: The risk of irreversible ototoxicity has recently been highlighted in patients receiving furosemide (Lasix) by rapid IV bolus injection in a number of clinical situations. The Lasix renogram (DR) is a commonly undertaken investigation in paediatric Nuclear Medicine. The quantity and rate of administration of diuretic have both been criticised as potentially hazardous, despite there being no recorded instances in the literature of deafness following DR. We have recently completed a study of 10 children with normal renal function (ages 3 weeks to 14 years) referred for standard DR. Audiometric assessment was undertaken prior to and immediately following completion of the renogram. The tests employed were: Tympanometry, Distortion-Product Otoacoustic Emissions (DPOAEs), Transient-Evoked Otoacoustic Emissions (TPOAEs) and where appropriate, Behavioural Audiometry. One child with unsuspected middle ear disease was excluded. Seventeen (17) ears were fully tested. All demonstrated a small, significant and reversible change in DPOAE amplitude. The other measured parameters were unchanged and there was no perceptual hearing impairment. These data suggest that Lasix renography has a measurable but subclinical effect on hearing children with normal renal function. We propose expanding the study to include a more representative sample of our referral population, including children with renal impairment. We aim to identify those patients in whom Lasix may be contraindicated. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc