[en] Objective: To explore the value of SPECT in the localization of epileptic foci. Methods: To determine epileptic foci, 34 epilepsy patients who were diagnosed by clinical history and EEG underwent ictal and interictal regional cerebral blood flow (rCBF) imaging with SPECT. Results: Twenty-two of 34 cases showed decreased brain blood flow perfusion on the interictal rCBF images, 28 of those showed increased brain blood flow perfusion on the ictal rCBF images. The patients whose epileptic foci had been localized by SPECT were treated with γ knife. conclusion: SPECT is of great value in the localization of epileptic foci