[en] Objective: To evaluate solitary pulmonary nodules (SPNs) using quantitative dynamic contrast enhanced functional computed tomography (CT), and to illustrate its clinical efficacy in differential diagnosis between benign and malignant pulmonary nodules. Methods: Eighty patients with non-calcified SPNs (diameter, 5-30 mm) were studied with dynamic contrast enhanced CT. Patterns of time-density curve (T-DC) were assessed. The precontrast density, peak height in density (PH: the maximum value of the T-DC), and S/A ratio (the ratio of the PH of SPN over aorta) were recorded. Enhancement patterns of SPNs were also recorded. The perfusion of SPNs was calculated. Results: Malignant, benign, and inflammatory nodules showed quite different patterns in T-DC. PH and S/A ratio of the malignant and inflammatory nodules were significantly higher than those of the benign nodules (P<0.0001; P<0.0001; χ²=32.62, P<0.0001; χ²=15.46, P<0.0001), while no statistical difference of the PH or S/A ratio was found between the malignant and inflammatory nodules (P=0.96; χ²=0.35, P=0.55). Precontrast density of the inflammatory nodules was lower than that of the malignant nodules (P<0.05). Both the malignant and inflammatory nodules showed significantly higher perfusions than that the benign nodules (P<0.001; P<0.01). However, the difference of the perfusion between the malignant nodules and inflammatory nodules was not significant (P=0.63). Conclusion: Dynamic contrast enhanced functional CT can provide quantitative information about blood flow patterns of SPNs and proved to be an alternate non-invasive option in the evaluation and management of solitary pulmonary nodules